Primary Site >> Liver Cancer

Gene >> FLT3

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Ref: Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.
PMID: 16890795
Ref: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.
PMID: 17178882
Ref: Protein kinase inhibitors in the treatment of renal cell carcinoma: sorafenib.
PMID: 17591826
Ref: Effective palliation of advanced cholangiocarcinoma with sorafenib: a two-patient case report.
PMID: 19089671
Ref: Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies.
PMID: 19894779
Ref: Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
PMID: 19940466
Ref: Effective treatment of advanced cholangiocarcinoma by hepatic arterial infusion chemotherapy combination with sorafenib: one case report from China.
PMID: 20698202
Ref: Elevated serum thymidine kinase 1 predicts risk of pre/early cancerous progression.
PMID: 21545220
Ref: Sunitinib induced pyoderma gangrenosum-like ulcerations.
PMID: 22027642
Ref: Transforming growth factor-beta-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis.
PMID: 21943131
Ref: Sorafenib (BAY 43-9006) in hepatocellular carcinoma patients: from discovery to clinical development.
PMID: 22214462
Ref: Rational drug design for identifying novel multi-target inhibitors for hepatocellular carcinoma.
PMID: 22583422
Ref: Discovery of potent, orally active compounds of tyrosine kinase and serine/threonine-protein kinase inhibitor with anti-tumor activity in preclinical assays.
PMID: 23983378
Ref: Sorafenib Induced Hand Foot Skin Rash in FLT3 ITD Mutated Acute Myeloid Leukemia-A Case Report and Review of Literature.
PMID: 24678393
Ref: Profile of nintedanib in the treatment of solid tumors: the evidence to date.
PMID: 26677336
Ref: Sorafenib-induced Posterior Reversible Encephalopathy Syndrome in a Child With FLT3-ITD-positive Acute Myeloid Leukemia.
PMID: 26907662
Ref: Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma.
PMID: 27511526
Ref: Cabozantinib in the treatment of hepatocellular carcinoma.
PMID: 28703624
Ref: Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
PMID: 29785143