Primary Site >> Colorectal Cancer
Gene >> FHIT
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Ref: The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. PMID: 8598045 Ref: Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines. PMID: 8640789 Ref: Evaluation of the FHIT gene in colorectal cancers. PMID: 8674044 |
Ref: Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. PMID: 9063739 Ref: Alternative splicing of the FHIT gene in colorectal cancers. PMID: 9197530 |
Ref: HIT family genes: FHIT but not PKCI-1/HINT produces altered transcripts in colorectal cancer. PMID: 10555761 |
Ref: Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions. PMID: 10646844 Ref: Clinicopathologic features and FHIT gene expression in sporadic colorectal adenocarcinomas. PMID: 10912665 Ref: Frequent altered expression of fragile histidine triad protein in human colorectal adenomas. PMID: 11071873 Ref: [Abnormal expression of the FHIT gene in human primary gastrointestinal cancers]. PMID: 12205991 |
Ref: Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma. PMID: 11606365 Ref: Fhit protein expression in hereditary and sporadic colorectal cancers. PMID: 11769399 Ref: [Loss of heterozygosity on chromosome 3 in sporadic colorectal carcinoma]. PMID: 11798895 |
Ref: Translational oncogenomics: toward rational therapeutic decision-making. PMID: 11880707 Ref: FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study. PMID: 12090476 Ref: [Recent advances in the diagnosis and treatment of colorectal cancers]. PMID: 12094697 Ref: Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma. PMID: 12177781 Ref: Deletion of the FHIT gene in human colorectal cancer is independent of high-risk HPV infection. PMID: 12355215 Ref: Loss of fragile histidine triad expression in colorectal carcinoma. PMID: 12419158 Ref: Microsatellite instability in a population of sporadic colorectal cancers: correlation between genetic and pathological profiles. PMID: 12502211 Ref: Loss of heterozygosity at the FHIT gene in different solid human tumours and its association with survival in colorectal cancer patients. PMID: 12530066 |
Ref: Microsatellite instability is often observed in esophageal carcinoma patients with allelic loss in the FHIT/FRA3B locus. PMID: 12697969 Ref: Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types. PMID: 12964015 |
Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 Ref: [Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]. PMID: 15025965 Ref: Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer. PMID: 15196543 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Aberrant FHIT transcripts in human colorectal cancers. PMID: 18426086 |
Ref: FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. PMID: 16510588 Ref: Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines. PMID: 16733051 Ref: Loss of p27 expression and microsatellite instability in sporadic colorectal cancer. PMID: 17123889 Ref: Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication. PMID: 17382535 |
Ref: Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. PMID: 17021745 Ref: Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition. PMID: 17373735 Ref: [Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma]. PMID: 17380463 Ref: FHIT oncosuppressor gene expression profile in human anal cancers. PMID: 17393360 Ref: Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns. PMID: 17693665 Ref: Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer. PMID: 24557667 |
Ref: Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms. PMID: 18097574 Ref: Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. PMID: 18301950 Ref: [Expression of nuclear factor-kappa-B/P65 and fragile histidine triad in colorectal carcinoma and clinical significance thereof]. PMID: 18646716 |
Ref: Appearance of epithelial and stromal genomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation to age and gender. PMID: 19590931 Ref: Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer. PMID: 20083853 |
Ref: [Impact of fragile histidine triad gene transfection on the proliferation and apoptosis of human colorectal cancer cell]. PMID: 20878579 |
Ref: Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma. PMID: 23443232 |
Ref: Single nucleotide polymorphism array analysis of microsatellite-stable, diploid/near-diploid colorectal carcinomas without the CpG island methylator phenotype. PMID: 23255915 Ref: Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation: indicators of tumor staging and metastasis in adenocarcinomatous sporadic colorectal cancer in Indian population. PMID: 23573237 Ref: Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer. PMID: 23797051 Ref: Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor. PMID: 23947369 |
Ref: Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma. PMID: 24370550 Ref: Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence. PMID: 25091577 |
Ref: Differential expressions of cancer-associated genes and their regulatory miRNAs in colorectal carcinoma. PMID: 25925209 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 |
Ref: A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/beta-catenin signalling pathway. PMID: 27462437 |
Ref: Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum. PMID: 28927131 Ref: Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair. PMID: 29069730 |
Ref: Do FHIT gene alterations play a role in human solid tumors? PMID: 29516675 |