Primary Site >> Colorectal Cancer
Gene >> FGFR2
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. PMID: 7923141 |
Ref: Overexpression of keratinocyte growth factor in cancer cells and enterochromaffin cells in human colorectal cancer. PMID: 10849325 |
Ref: Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. PMID: 11325814 Ref: A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor. PMID: 11563979 Ref: Expression of fibroblast growth factor (FGF)-10 in human colorectal adenocarcinoma cells. PMID: 11598623 |
Ref: Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer. PMID: 15643506 Ref: Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. PMID: 15705896 Ref: Comparative genomics on Shisa orthologs. PMID: 15942696 |
Ref: Low penetrance breast cancer predisposition SNPs are site specific. PMID: 19005751 Ref: Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells. PMID: 19148469 Ref: Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. PMID: 19437480 Ref: Integrative genomics reveals mechanisms of copy number alterations responsible for transcriptional deregulation in colorectal cancer. PMID: 19691111 |
Ref: SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. PMID: 21691074 Ref: Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer. PMID: 21745712 |
Ref: Integrated analysis of whole genome exon array and array-comparative genomic hybridization in gastric and colorectal cancer cells. PMID: 22034905 Ref: CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells. PMID: 22157717 Ref: Fibroblast growth factor receptor 2: expression, roles, and potential as a novel molecular target for colorectal cancer. PMID: 22701813 Ref: Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. PMID: 22751462 Ref: Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells. PMID: 22778155 |
Ref: Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines. PMID: 23353574 Ref: S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. PMID: 23804704 |
Ref: Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells. PMID: 24027017 Ref: Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APC(Min/+) mice. PMID: 24507628 Ref: C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2. PMID: 24758762 Ref: FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival. PMID: 24968263 Ref: Fibroblast growth factor receptor 2 overexpression is predictive of poor prognosis in rectal cancer patients receiving neoadjuvant chemoradiotherapy. PMID: 25271212 |
Ref: AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells. PMID: 25691251 Ref: Protein domain-level landscape of cancer-type-specific somatic mutations. PMID: 25794154 Ref: The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. PMID: 25926053 Ref: The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. PMID: 26506517 Ref: In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer. PMID: 26675289 |
Ref: Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status. PMID: 26831663 Ref: Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease. PMID: 27063727 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 |
Ref: Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia. PMID: 28524162 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: FGFR2 amplification in colorectal adenocarcinoma. PMID: 28835367 Ref: Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step. PMID: 28871001 |
Ref: FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro. PMID: 29573334 Ref: A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer. PMID: 29936137 Ref: FGFR3 mRNA overexpression defines a subset of oligometastatic colorectal cancers with worse prognosis. PMID: 30181810 |