Primary Site >> Colorectal Cancer
Gene >> FGF19
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Ref: Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. PMID: 17599042 Ref: Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling. PMID: 18593907 |
Ref: Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. PMID: 21747170 |
Ref: Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys. PMID: 22268002 Ref: Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities. PMID: 22396171 Ref: Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19. PMID: 22561792 Ref: Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. PMID: 22800197 Ref: Regulation of amphiregulin gene expression by beta-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PMID: 23285165 |
Ref: Lack of relationships between FGF19 staining pattern, lymph node metastasis and locally invasive characteristics of the tumor in colorectal cancers. PMID: 23803094 |
Ref: FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3beta/beta- catenin signaling cascade via FGFR4 activation. PMID: 26498355 Ref: Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport. PMID: 27929465 |
Ref: The role of bile acids in the pathogenesis of bowel diseases. PMID: 28894048 |
Ref: Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient mice. PMID: 29876009 |