Primary Site >> Pancreatic Cancer
Gene >> FBXW7
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Ref: BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. PMID: 14507635 |
Ref: Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. PMID: 17440062 |
Ref: Genistein down-regulates miR-223 expression in pancreatic cancer cells. PMID: 23834147 |
Ref: Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer. PMID: 24899509 |
Ref: Molecular landscape of pancreatic cancer: implications for current clinical trials. PMID: 11051691 Ref: Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. PMID: 25638153 Ref: Molecular landscape of pancreatic cancer: implications for current clinical trials. PMID: 25714017 Ref: ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. PMID: 25753158 |
Ref: FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer. PMID: 26983463 Ref: Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy. PMID: 27034805 Ref: Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting beta-catenin for degradation in pancreatic cancer. PMID: 27485116 Ref: Fbxw7 Deletion Accelerates Kras(G12D)-Driven Pancreatic Tumorigenesis via Yap Accumulation. PMID: 27764699 |
Ref: Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture. PMID: 28099906 Ref: CDK5/FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion. PMID: 28242758 Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1. PMID: 28765935 Ref: Reduced FBXW7 expression in pancreatic cancer correlates with poor prognosis and chemotherapeutic resistance via accumulation of MCL1. PMID: 29348852 |