Primary Site >> Colorectal Cancer
Gene >> FBXW7
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Ref: Inactivation of hCDC4 can cause chromosomal instability. PMID: 14999283 Ref: hCDC4 and genetic instability in cancer. PMID: 15118416 |
Ref: CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. PMID: 16357143 |
Ref: The FBXW7 beta-form is suppressed in human glioma cells. PMID: 17274947 Ref: Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. PMID: 17440062 Ref: High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. PMID: 17457043 |
Ref: Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors. PMID: 19420964 |
Ref: Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance. PMID: 19739118 Ref: F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. PMID: 20638938 |
Ref: FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. PMID: 21282377 Ref: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. PMID: 21368833 |
Ref: Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells. PMID: 22285861 Ref: Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer. PMID: 22473991 Ref: miR-23a promotes the transition from indolent to invasive colorectal cancer. PMID: 22628407 |
Ref: Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells. PMID: 23558291 Ref: MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death. PMID: 23816886 Ref: Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations. PMID: 24042191 |
Ref: Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. PMID: 23676439 Ref: Fbxw7 hotspot mutations and human colon cancer: mechanistic insights from new mouse models. PMID: 24000292 Ref: Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients. PMID: 24170544 Ref: A colon cancer-derived mutant of Kruppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3beta (GSK3beta) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7alpha (FBW7alpha). PMID: 24398687 Ref: An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PMID: 24475022 Ref: FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. PMID: 24586741 Ref: Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors. PMID: 24706189 Ref: Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing. PMID: 25066378 Ref: Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma. PMID: 25269767 Ref: Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions. PMID: 25275295 |
Ref: FBXW7 mutation analysis and its correlation with clinicopathological features and prognosis in colorectal cancer patients. PMID: 25450649 Ref: A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas. PMID: 25617745 Ref: FBXW7 acts as an independent prognostic marker and inhibits tumor growth in human osteosarcoma. PMID: 25622249 Ref: Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis. PMID: 25623536 Ref: Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer. PMID: 25786087 Ref: Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer. PMID: 25855785 Ref: FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. PMID: 25860929 Ref: Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era. PMID: 25974029 Ref: FBXW7 negatively regulates ENO1 expression and function in colorectal cancer. PMID: 26097998 Ref: Genetic mutations in human rectal cancers detected by targeted sequencing. PMID: 26134512 Ref: High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer. PMID: 26375816 Ref: Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients. PMID: 26508446 Ref: [Alternative Splicing Detection as a Biomarker for Cancer Diagnosis: A Novel Progressive Mechanism of Acute Lymphoblastic Leukemia with Alternative Splicing as a Biomarker Candidate]. PMID: 26731899 |
Ref: Next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas. PMID: 26536055 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture. PMID: 27110583 Ref: Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples. PMID: 27146902 Ref: Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing. PMID: 27155048 Ref: Genomic Landscape of Colorectal Mucosa and Adenomas. PMID: 27221540 Ref: Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. PMID: 27244218 Ref: Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer. PMID: 27417709 Ref: Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E in colorectal cancer. PMID: 27423313 Ref: Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3beta-Dependent Manner. PMID: 27470268 Ref: Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations. PMID: 27499925 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients. PMID: 27729614 Ref: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. PMID: 27756406 Ref: Molecular spectrum of KRAS, NRAS, BRAF, PIK3CA, TP53, and APC somatic gene mutations in Arab patients with colorectal cancer: determination of frequency and distribution pattern. PMID: 28078112 Ref: Somatic mutation detection using various targeted detection assays in paired samples of circulating tumor DNA, primary tumor and metastases from patients undergoing resection of colorectal liver metastases. PMID: 28949453 |
Ref: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation. PMID: 27399335 Ref: Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates. PMID: 27609830 Ref: Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells. PMID: 28202514 Ref: Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform. PMID: 28243320 Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: FAM83D knockdown regulates proliferation, migration and invasion of colorectal cancer through inhibiting FBXW7/Notch-1 signalling pathway. PMID: 28407575 Ref: FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma. PMID: 28424412 Ref: FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors. PMID: 28619760 Ref: Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer. PMID: 28678173 Ref: Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody. PMID: 28685087 Ref: Colorectal Cancer Stem Cells Acquire Chemoresistance Through the Upregulation of F-Box/WD Repeat-Containing Protein 7 and the Consequent Degradation of c-Myc. PMID: 28699179 Ref: Molecular characterization of circulating colorectal tumor cells defines genetic signatures for individualized cancer care. PMID: 28978093 Ref: Increased Frequency of KRAS Mutations in African Americans Compared with Caucasians in Sporadic Colorectal Cancer. PMID: 29048416 Ref: Acquired somatic TP53 or PIK3CA mutations are potential predictors of when polyps evolve into colorectal cancer. PMID: 29069792 |
Ref: Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor. PMID: 28963353 Ref: A mutational comparison of adult and adolescent and young adult (AYA) colon cancer. PMID: 29194591 Ref: Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer. PMID: 29282223 Ref: The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. PMID: 29346117 Ref: Phosphatidylinositol 3-Kinase alpha-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study. PMID: 29401002 Ref: Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. PMID: 29453410 Ref: Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study. PMID: 29511559 Ref: Genetic Deletion of Fbw7 in the mouse intestinal epithelium aggravated dextran sodium sulfate-induced colitis by modulating the inflammatory response of NF-kappaB pathway. PMID: 29550488 Ref: Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3beta and F-box and WD repeat domain-containing 7. PMID: 29628506 Ref: miR-92b-3p Promotes Colorectal Carcinoma Cell Proliferation, Invasion, and Migration by Inhibiting FBXW7 In Vitro and In Vivo. PMID: 29638162 Ref: MiR-223 promotes the doxorubicin resistance of colorectal cancer cells via regulating epithelial-mesenchymal transition by targeting FBXW7. PMID: 29701752 Ref: Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients. PMID: 29705968 Ref: Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism. PMID: 29735700 Ref: Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. PMID: 29755662 Ref: Massively parallel sequencing analysis of mucinous ovarian carcinomas: genomic profiling and differential diagnoses. PMID: 29793804 Ref: FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1alpha/CEACAM5 functional axis. PMID: 29910683 Ref: The landscape of somatic mutation in sporadic Chinese colorectal cancer. PMID: 29937994 Ref: Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. PMID: 29945573 Ref: Differences in gene mutations according to gender among patients with colorectal cancer. PMID: 29976257 Ref: Deep sequencing and pathway-focused analysis revealed multigene oncodriver signatures predicting survival outcomes in advanced colorectal cancer. PMID: 30032163 |