Primary Site >> Colorectal Cancer
Gene >> FASN
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Ref: Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. PMID: 9006336 Ref: Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. PMID: 9191002 |
Ref: Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. PMID: 10632348 |
Ref: Synthesis and antitumor activity of an inhibitor of fatty acid synthase. PMID: 10716717 Ref: Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia. PMID: 11082286 |
Ref: Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. PMID: 11245456 |
Ref: [The construction of yeast two-hybrid method in the protein-interactions and its significance in hepatic metastasis of colorectal carcinoma]. PMID: 15329257 |
Ref: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. PMID: 16118624 Ref: Overexpression of fatty acid synthase in ulcerative colitis. PMID: 16753600 Ref: Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex. PMID: 17687193 |
Ref: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. PMID: 17283163 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? PMID: 18253084 |
Ref: Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. PMID: 18239060 Ref: PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. PMID: 18516290 Ref: Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells. PMID: 18794082 Ref: Cohort study of fatty acid synthase expression and patient survival in colon cancer. PMID: 18955444 |
Ref: Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane. PMID: 19173288 Ref: Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. PMID: 19186181 Ref: Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. PMID: 19358283 Ref: Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. PMID: 19412426 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target. PMID: 19491830 Ref: A cohort study of p27 localization in colon cancer, body mass index, and patient survival. PMID: 19505918 Ref: A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis. PMID: 19513025 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Interaction of molecular markers and physical activity on mortality in patients with colon cancer. PMID: 19723652 |
Ref: CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. PMID: 19790197 Ref: Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. PMID: 20228137 Ref: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. PMID: 20491775 Ref: Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. PMID: 20507599 Ref: The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy. PMID: 20551061 Ref: Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids. PMID: 20691246 Ref: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. PMID: 20808308 Ref: GREEN TEA POLYPHENOLS MEDIATED APOPTOSIS IN INTESTINAL EPITHELIAL CELLS BY A FADD-DEPENDENT PATHWAY. PMID: 21687829 |
Ref: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. PMID: 20473920 Ref: Phosphorylated AKT expression is associated with PIK3CA mutation, low stage, and favorable outcome in 717 colorectal cancers. PMID: 21425139 Ref: Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. PMID: 21437031 Ref: Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. PMID: 21723078 Ref: The colorectal tumor microenvironment: the next decade. PMID: 21735168 |
Ref: Serum levels of fatty acid synthase in colorectal cancer patients are associated with tumor stage. PMID: 21727995 Ref: Low levels of lipogenic enzymes in peritumoral adipose tissue of colorectal cancer patients. PMID: 22090062 Ref: The "HER2-PI3K/Akt-FASN Axis" regulated malignant phenotype of colorectal cancer cells. PMID: 22218925 Ref: Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. PMID: 22266115 Ref: Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the nurses' health study. PMID: 22312135 Ref: SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PMID: 22457791 Ref: A significant role of lipogenic enzymes in colorectal cancer. PMID: 22753716 Ref: Fatty acid synthase regulates proliferation and migration of colorectal cancer cells via HER2-PI3K/Akt signaling pathway. PMID: 22860766 Ref: Cytosolic malic enzyme 1 (ME1) mediates high fat diet-induced adiposity, endocrine profile, and gastrointestinal tract proliferation-associated biomarkers in male mice. PMID: 23056418 Ref: Expression profiling of archival tumors for long-term health studies. PMID: 23136189 |
Ref: The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. PMID: 22722903 Ref: Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells. PMID: 23725225 Ref: Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. PMID: 23754252 |
Ref: Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes. PMID: 24430360 Ref: Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. PMID: 24510238 Ref: Alpha-2-glycoprotein 1(AZGP1) regulates biological behaviors of LoVo cells by down-regulating mTOR signaling pathway and endogenous fatty acid synthesis. PMID: 24918753 Ref: Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. PMID: 25155760 Ref: Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. PMID: 25173531 |
Ref: Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells. PMID: 25451013 Ref: Remodeling of phospholipid composition in colon cancer cells by 1alpha,25(OH)2D3 and its analogs. PMID: 25625664 Ref: Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. PMID: 25970773 Ref: Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro. PMID: 26035182 Ref: L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-gamma Signaling Pathway. PMID: 26452216 Ref: Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. PMID: 26506839 Ref: Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways. PMID: 26517691 |
Ref: Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway. PMID: 26109148 Ref: Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. PMID: 27139420 |
Ref: Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis. PMID: 28260110 Ref: Dietary glycemic and insulin scores and colorectal cancer survival by tumor molecular biomarkers. PMID: 28268248 Ref: MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression. PMID: 28339092 Ref: Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status. PMID: 28510098 Ref: Expression of fatty acid synthase is regulated by PGC1alpha and contributes to increased cell proliferation. PMID: 29130104 |
Ref: Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study. PMID: 29681001 Ref: Biologic Response of Colorectal Cancer Xenograft Tumors to Sequential Treatment with Panitumumab and Bevacizumab. PMID: 29802988 Ref: Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. PMID: 29872506 Ref: De Novo Fatty Acid Synthesis Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. PMID: 30154249 Ref: In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines. PMID: 30256698 |