Primary Site >> Colorectal Cancer
Gene >> F2R
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Ref: Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. PMID: 9808563 |
Ref: Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells. PMID: 10807779 |
Ref: Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells. PMID: 12707033 Ref: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2. PMID: 14511767 |
Ref: Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. PMID: 15383630 Ref: PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. PMID: 15559761 |
Ref: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell. PMID: 15655297 Ref: Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. PMID: 16091733 |
Ref: Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation. PMID: 16885380 |
Ref: Microfluidic reveals generation of platelet-strings on tumor-activated endothelium. PMID: 17721608 |
Ref: PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. PMID: 18854173 Ref: The expression and the functional roles of tissue factor and protease-activated receptor-2 on SW620 cells. PMID: 18949403 |
Ref: Differential effects of anticoagulants on tumor development of mouse cancer cell lines B16, K1735 and CT26 in lung. PMID: 19067186 Ref: Coagulation factor Xa inhibits cancer cell migration via protease-activated receptor-1 activation. PMID: 19250659 |
Ref: Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells. PMID: 20056842 Ref: Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation. PMID: 20347121 Ref: Novel agonists and antagonists for human protease activated receptor 2. PMID: 20873792 |
Ref: Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells. PMID: 20857420 Ref: Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells. PMID: 21907696 |
Ref: Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells. PMID: 22968820 |
Ref: Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. PMID: 25846512 Ref: Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. PMID: 26238780 Ref: Genetic polymorphisms of PAI-1 and PAR-1 are associated with acute normal tissue toxicity in Chinese rectal cancer patients treated with pelvic radiotherapy. PMID: 26347502 |
Ref: [Corrigendum] Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. PMID: 26718652 Ref: PO-51 - Expression of proteins of the tissue factor thrombin pathway is upregulated in the stroma and epithelium of colorectal cancer. PMID: 27161738 Ref: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. PMID: 27313176 |
Ref: Molecular targeting of breast and colon cancer cells by PAR1 mediated apoptosis through a novel pro-apoptotic peptide. PMID: 30196356 |