Primary Site >> Liver Cancer
Gene >> EZH2
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Ref: Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma. PMID: 15856046 |
Ref: The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens. PMID: 17024127 |
Ref: Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. PMID: 17584191 Ref: Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin. PMID: 17596871 Ref: Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma. PMID: 17676662 |
Ref: The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma. PMID: 18591938 |
Ref: Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma. PMID: 19386347 |
Ref: PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells. PMID: 20444294 Ref: RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo. PMID: 20684863 |
Ref: Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. PMID: 20952513 Ref: EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies. PMID: 21330577 Ref: p53-paralog DNp73 oncogene is repressed by IFNalpha/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. PMID: 21399658 Ref: Hepatitis B virus X protein regulates the mEZH2 promoter via the E2F1-binding site in AML12 cells. PMID: 21439249 Ref: EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis. PMID: 21512140 Ref: Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. PMID: 21769904 |
Ref: The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. PMID: 21672940 Ref: 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells. PMID: 21717453 Ref: Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. PMID: 22370893 Ref: Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells. PMID: 22465358 Ref: Enhancer of zeste homologue 2 (EZH2) is a reliable immunohistochemical marker to differentiate malignant and benign hepatic tumors. PMID: 22809481 Ref: MiR-214 targets beta-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PMID: 22962603 Ref: Analysis of possible mechanisms accounting for raf-1 kinase inhibitor protein downregulation in hepatocellular carcinoma. PMID: 23095110 |
Ref: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. PMID: 22614017 Ref: RNAi-mediated EZH2 depletion decreases MDR1 expression and sensitizes multidrug-resistant hepatocellular carcinoma cells to chemotherapy. PMID: 23291714 Ref: Genetics and epigenetics of liver cancer. PMID: 23392071 Ref: Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2. PMID: 23421437 Ref: Primary liver sarcomatous carcinoma: report of two cases and review of the literature. PMID: 23484778 Ref: Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer. PMID: 23523318 Ref: Silencing the EZH2 gene by RNA interference reverses the drug resistance of human hepatic multidrug-resistant cancer cells to 5-Fu. PMID: 23562851 Ref: Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins. PMID: 23620257 Ref: Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model. PMID: 23720769 Ref: EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers. PMID: 23826380 Ref: Effects of EZH2 polymorphisms on susceptibility to and pathological development of hepatocellular carcinoma. PMID: 24040354 Ref: Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers. PMID: 24079712 Ref: Effects of EZH2 gene on the growth and migration of hepatocellular carcinoma HepG2 cells. PMID: 24570920 |
Ref: A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2. PMID: 23897557 Ref: c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma. PMID: 24002871 Ref: Telbivudine treatment corrects HBV-induced epigenetic alterations in liver cells of patients with chronic hepatitis B. PMID: 24067902 Ref: MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity. PMID: 24211739 Ref: The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma. PMID: 24845612 Ref: Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells. PMID: 24861464 Ref: EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. PMID: 24916103 Ref: Histone-modifying genes as biomarkers in hepatocellular carcinoma. PMID: 24966962 Ref: Aberrant upregulation of 14-3-3sigma and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular carcinoma. PMID: 25226601 Ref: Regulation of gene expression in HBV- and HCV-related hepatocellular carcinoma: integrated GWRS and GWGS analyses. PMID: 25550913 |
Ref: miR-26a promoted by interferon-alpha inhibits hepatocellular carcinoma proliferation and migration by blocking EZH2. PMID: 25494962 Ref: A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. PMID: 25500144 Ref: miR-214 as a key hub that controls cancer networks: small player, multiple functions. PMID: 25501033 Ref: DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. PMID: 25595591 Ref: CUL4B: a novel epigenetic driver in Wnt/beta-catenin-dependent hepatocarcinogenesis. PMID: 25664533 Ref: Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets. PMID: 25693145 Ref: Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling. PMID: 26024833 Ref: MicroRNA-1297 regulates hepatocellular carcinoma cell proliferation and apoptosis by targeting EZH2. PMID: 26191190 Ref: Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell. PMID: 26243049 Ref: Histone Deacetylase HDAC8 Promotes Insulin Resistance and beta-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma. PMID: 26383163 Ref: EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma. PMID: 26404566 Ref: Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations. PMID: 26431491 Ref: Tumor Suppressive Function of p21-activated Kinase 6 in Hepatocellular Carcinoma. PMID: 26442588 Ref: Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma. PMID: 26517514 Ref: Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma. PMID: 26693053 |
Ref: Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. PMID: 25893293 Ref: Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications. PMID: 26343958 Ref: Reciprocal negative feedback loop between EZH2 and miR-101-1 contributes to miR-101 deregulation in hepatocellular carcinoma. PMID: 26718325 Ref: MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2. PMID: 26733151 Ref: Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-kappaB in hepatocellular carcinoma. PMID: 26800240 Ref: Enhancer of zeste homolog 2 depletion arrests the proliferation of hepatoblastoma cells. PMID: 26848027 Ref: In silico and experimental analyses predict the therapeutic value of an EZH2 inhibitor GSK343 against hepatocellular carcinoma through the induction of metallothionein genes. PMID: 26973856 Ref: microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect. PMID: 27001970 Ref: CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma. PMID: 27207647 Ref: The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells. PMID: 27231134 Ref: lnc-beta-Catm elicits EZH2-dependent beta-catenin stabilization and sustains liver CSC self-renewal. PMID: 27239797 Ref: Inflammatory related gene IKKalpha, IKKbeta, IKKgamma cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. PMID: 27367027 Ref: Long noncoding RNA GIHCG promotes hepatocellular carcinoma progression through epigenetically regulating miR-200b/a/429. PMID: 27380494 Ref: Long noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expression. PMID: 27496341 Ref: Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. PMID: 27501756 Ref: Hypoxia-induced NIPP1 activation enhances metastatic potential and predicts poor prognosis in hepatocellular carcinoma. PMID: 27644248 Ref: The relationship between the expression of USP22, BMI1, and EZH2 in hepatocellular carcinoma and their impacts on prognosis. PMID: 27920552 |
Ref: Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. PMID: 27246976 Ref: A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets. PMID: 27721404 Ref: miR-98 inhibits hepatocellular carcinoma cell proliferation via targeting EZH2 and suppressing Wnt/beta-catenin signaling pathway. PMID: 27890434 Ref: Overexpression of the long non-coding RNA SPRY4-IT1 promotes tumor cell proliferation and invasion by activating EZH2 in hepatocellular carcinoma. PMID: 27899259 Ref: Long non-coding RNA SNHG20 predicts a poor prognosis for HCC and promotes cell invasion by regulating the epithelial-to-mesenchymal transition. PMID: 28282787 Ref: Long non-coding RNA HNF1A-AS1 promotes hepatocellular carcinoma cell proliferation by repressing NKD1 and P21 expression. PMID: 28292020 Ref: Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2. PMID: 28338656 Ref: Linc00152 promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma. PMID: 28343069 Ref: HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis. PMID: 28580773 Ref: Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression. PMID: 28760736 Ref: Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214. PMID: 28800314 Ref: STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. PMID: 28810927 Ref: Promotion of LncRNA HOXA11-AS on the proliferation of hepatocellular carcinoma by regulating the expression of LATS1. PMID: 28829501 Ref: Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA. PMID: 28846110 Ref: 20(S)-Ginsenoside Rh2 suppresses proliferation and migration of hepatocellular carcinoma cells by targeting EZH2 to regulate CDKN2A-2B gene cluster transcription. PMID: 28928088 Ref: Enhancing chemotherapy sensitivity by targeting PcG via the ATM/p53 pathway. PMID: 28979810 Ref: Long non-coding RNA SNHG20 promotes non-small cell lung cancer cell proliferation and migration by epigenetically silencing of P21 expression. PMID: 28981099 Ref: Long non-coding RNA CARLo-5 promotes tumor progression in hepatocellular carcinoma via suppressing miR-200b expression. PMID: 29050269 Ref: Epigenetic analysis of FHL1 tumor suppressor gene in human liver cancer. PMID: 29113254 Ref: Long non-coding RNA SNHG15 inhibits P15 and KLF2 expression to promote pancreatic cancer proliferation through EZH2-mediated H3K27me3. PMID: 29137412 Ref: MicroRNA137 has a suppressive role in liver cancer via targeting EZH2. PMID: 29152663 Ref: SAMMSON drives the self-renewal of liver tumor initiating cells through EZH2-dependent Wnt/beta-catenin activation. PMID: 29262600 Ref: Long non-coding RNA HOXA11-AS promotes the proliferation HCC cells by epigenetically silencing DUSP5. PMID: 29312625 |
Ref: From large to small: the immunohistochemical panel in the diagnosis of early hepatocellular carcinoma. PMID: 28881044 Ref: Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. PMID: 28939663 Ref: lncRNA MIAT promotes proliferation and invasion of HCC cells via sponging miR-214. PMID: 29097358 Ref: LncAPC drives Wnt/beta-catenin activation and liver TIC self-renewal through EZH2 mediated APC transcriptional inhibition. PMID: 29144570 Ref: Long noncoding RNA PCAT-1 acts as an oncogene in osteosarcoma by reducing p21 levels. PMID: 29291409 Ref: EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis. PMID: 29316949 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Expression of EZH2 is associated with poor outcome in colorectal cancer. PMID: 29435024 Ref: Association between EZH2 Genetic Variants and Hepatocellular Carcinoma in a Chinese Han Population. PMID: 29479874 Ref: Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search. PMID: 29498708 Ref: [Corrigendum] MicroRNA-137 has a suppressive role in liver cancer via targeting EZH2. PMID: 29568886 Ref: The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma. PMID: 29574790 Ref: Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells. PMID: 29581297 Ref: MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma. PMID: 29653269 Ref: Upregulation of LncDQ is Associated with Poor Prognosis and Promotes Tumor Progression via Epigenetic Regulation of the EMT Pathway in HCC. PMID: 29669339 Ref: LncRNA SOX21-AS1 is associated with progression of hepatocellular carcinoma and predicts prognosis through epigenetically silencing p21. PMID: 29772433 Ref: Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors. PMID: 29858058 Ref: Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. PMID: 29992318 Ref: Long noncoding RNA PVT1 modulates hepatocellular carcinoma cell proliferation and apoptosis by recruiting EZH2. PMID: 30008615 Ref: Dysfunction of Sister Chromatids Separation Promotes Progression of Hepatocellular Carcinoma According to Analysis of Gene Expression Profiling. PMID: 30100882 Ref: Androgen receptor drives hepatocellular carcinogenesis by activating enhancer of zeste homolog 2-mediated Wnt/beta-catenin signaling. PMID: 30150059 Ref: LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation. PMID: 30195653 Ref: MiR-137 suppresses migration and invasion by targeting EZH2-STAT3 signaling in human hepatocellular carcinoma. PMID: 30274685 Ref: HANR promotes hepatocellular carcinoma progression via miR-214/EZH2/TGF-beta axis. PMID: 30342849 |