Primary Site >> Colorectal Cancer
Gene >> EZH2
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Ref: Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy. PMID: 12533679 |
Ref: Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. PMID: 15231737 |
Ref: Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases. PMID: 15837043 |
Ref: PcG proteins, DNA methylation, and gene repression by chromatin looping. PMID: 19053175 |
Ref: Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis. PMID: 19773751 |
Ref: EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis. PMID: 20480530 Ref: The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. PMID: 20631058 Ref: Epigenetic silencing of peroxisome proliferator-activated receptor gamma is a biomarker for colorectal cancer progression and adverse patients' outcome. PMID: 21151932 |
Ref: Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. PMID: 21539681 Ref: EZH2 depletion blocks the proliferation of colon cancer cells. PMID: 21765901 Ref: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. PMID: 21862635 |
Ref: An EZH2 polymorphism is associated with clinical outcome in metastatic colorectal cancer patients. PMID: 21926398 Ref: TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer. PMID: 22130667 Ref: EZH2 polymorphism and benefit from bevacizumab in colorectal cancer: another piece to the puzzle. PMID: 22383679 Ref: MiR-214 targets beta-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PMID: 22962603 |
Ref: Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells. PMID: 23001792 Ref: EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells. PMID: 23116973 Ref: Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer. PMID: 23424038 Ref: Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer. PMID: 23523318 Ref: Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells. PMID: 23588203 Ref: Update of research on the role of EZH2 in cancer progression. PMID: 23589697 Ref: PAF and EZH2 induce Wnt/beta-catenin signaling hyperactivation. PMID: 24055345 Ref: PAF makes it EZ(H2) for beta-catenin transactivation. PMID: 24210173 |
Ref: Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer. PMID: 24346863 Ref: Association between EZH2 polymorphisms and colorectal cancer risk in Han Chinese population. PMID: 24488618 Ref: Role of C9orf140 in the promotion of colorectal cancer progression and mechanisms of its upregulation via activation of STAT5, beta-catenin and EZH2. PMID: 24608043 Ref: Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer. PMID: 25032847 Ref: Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4. PMID: 25081869 Ref: The prognostic role of EZH2 expression in rectal cancer patients treated with neoadjuvant chemoradiotherapy. PMID: 25159232 Ref: Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition. PMID: 25229454 Ref: Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer. PMID: 25243792 Ref: Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. PMID: 25261372 Ref: EZH2 inhibition enhances the efficacy of an EGFR inhibitor in suppressing colon cancer cells. PMID: 25535899 Ref: JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. PMID: 25542019 Ref: EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene. PMID: 25549357 |
Ref: Inhibition of EZH2 expression is associated with the proliferation, apoptosis, and migration of SW620 colorectal cancer cells in vitro. PMID: 25005166 Ref: Expression and clinicopathological significance of EED, SUZ12 and EZH2 mRNA in colorectal cancer. PMID: 25326896 Ref: Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2. PMID: 25486432 Ref: DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. PMID: 25595591 Ref: Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer. PMID: 25611389 Ref: Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. PMID: 25653233 Ref: Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer. PMID: 25695204 Ref: Inhibition of EZH2 expression is associated with the proliferation, apoptosis and migration of SW620 colorectal cancer cells in vitro. PMID: 25724194 Ref: Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. PMID: 26235356 Ref: Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer. PMID: 26305882 Ref: The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer. PMID: 26336990 Ref: Restoration of IGF2 imprinting by polycomb repressive complex 2 docking factor SUZ12 in colon cancer cells. PMID: 26407907 Ref: MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2. PMID: 26452129 Ref: Wnt2 complements Wnt/beta-catenin signaling in colorectal cancer. PMID: 26484565 Ref: Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer. PMID: 26553291 Ref: DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis. PMID: 26579445 Ref: Prognostic significance of EZH2 expression in patients with digestive cancers: a meta-analysis. PMID: 26629110 Ref: Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway. PMID: 26735435 |
Ref: PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer. PMID: 26567139 Ref: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. PMID: 26785732 Ref: Prognostic significance of EZH2 expression in patients with oesophageal cancer: a meta-analysis. PMID: 26859127 Ref: The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway. PMID: 26871294 Ref: Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer. PMID: 26930714 Ref: EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/beta-catenin signaling. PMID: 27172794 Ref: Long noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expression. PMID: 27496341 Ref: Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. PMID: 27634879 Ref: EZH2 inhibitors transcriptionally upregulate cytotoxic autophagy and cytoprotective unfolded protein response in human colorectal cancer cells. PMID: 27648357 Ref: Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKClambda/iota. PMID: 27653691 Ref: Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells. PMID: 27706111 Ref: RETRACTION of articles with plagiarism in common with other publications. PMID: 27706792 Ref: EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells. PMID: 27882937 |
Ref: Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. PMID: 27246976 Ref: LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression. PMID: 27983539 Ref: Methyl jasmonate induces the apoptosis of human colorectal cancer cells via downregulation of EZH2 expression by microRNA101. PMID: 28000868 Ref: MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2. PMID: 28069878 Ref: Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer. PMID: 28112720 Ref: EZH2 expression is a prognostic biomarker in patients with colorectal cancer treated with anti-EGFR therapeutics. PMID: 28147317 Ref: Multicellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis To Evaluate Epigenetic Drugs. PMID: 28194967 Ref: Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15. PMID: 28277544 Ref: Targeting histone methylation for colorectal cancer. PMID: 28286564 Ref: The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression. PMID: 28381186 Ref: Upregulation of CCAT2 promotes cell proliferation by repressing the P15 in breast cancer. PMID: 28531944 Ref: The Significant Pathways and Genes Underlying the Colon Cancer Treatment by the Traditional Chinese Medicine PHY906. PMID: 28588641 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: EZH2 is involved in silencing of WNT5A during epithelial-mesenchymal transition of colon cancer cell line. PMID: 28748258 Ref: Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. PMID: 28796262 Ref: STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. PMID: 28827371 Ref: lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-kappaB/TS Signaling in Colorectal Cancer. PMID: 28918035 Ref: A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer. PMID: 28938648 Ref: Deregulated expression of microRNA-200b/c and SUZ12, a Polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells. PMID: 28966728 Ref: Long non-coding RNA SNHG20 promotes non-small cell lung cancer cell proliferation and migration by epigenetically silencing of P21 expression. PMID: 28981099 Ref: DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer. PMID: 29021137 Ref: The role of EZH2 in overall survival of colorectal cancer: a meta-analysis. PMID: 29061982 Ref: Ginkgo biloba extract EGb 761-induced upregulation of LincRNA-p21 inhibits colorectal cancer metastasis by associating with EZH2. PMID: 29207671 Ref: A missense variant in EZH2 is associated with colorectal cancer risk in a Chinese population. PMID: 29212262 |
Ref: Loss of TET1 facilitates DLD1 colon cancer cell migration via H3K27me3-mediated down-regulation of E-cadherin. PMID: 28513825 Ref: (-)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells. PMID: 28925507 Ref: Knockdown of pseudogene derived from lncRNA DUXAP10 inhibits cell proliferation, migration, invasion, and promotes apoptosis in pancreatic cancer. PMID: 29286182 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by Downregulating Bmi-1 Through Enhanced miR-200c Expression. PMID: 29418071 Ref: Expression of EZH2 is associated with poor outcome in colorectal cancer. PMID: 29435024 Ref: Osteopontin-integrin engagement induces HIF-1alpha-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. PMID: 29435158 Ref: Long non-coding RNA XIST regulates miR-137-EZH2 axis to promote tumor metastasis in colorectal cancer. PMID: 29495975 Ref: Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer. PMID: 29535803 Ref: HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression. PMID: 29654889 Ref: Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer. PMID: 29710537 Ref: Long Non-Coding RNA SH3PXD2A-AS1 Promotes Cell Progression Partly Through Epigenetic Silencing P57 and KLF2 in Colorectal Cancer. PMID: 29734178 Ref: The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells. PMID: 29772566 Ref: Long noncoding RNA AFAP1-AS1 facilitates tumor growth through enhancer of zeste homolog 2 in colorectal cancer. PMID: 29888110 Ref: The SLC34A2-ROS-HIF-1-induced upregulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer. PMID: 30038060 Ref: EZH2 inhibition promotes methyl jasmonate-induced apoptosis of human colorectal cancer through the Wnt/beta-catenin pathway. PMID: 30061944 Ref: A Novel lncRNA, LINC00460, Affects Cell Proliferation and Apoptosis by Regulating KLF2 and CUL4A Expression in Colorectal Cancer. PMID: 30092404 Ref: O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit. PMID: 30093632 Ref: Prognostic value of histone marks H3K27me3 and H3K9me3 and modifying enzymes EZH2, SETDB1 and LSD-1 in colorectal cancer. PMID: 30105513 Ref: SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer. PMID: 30157475 Ref: Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. PMID: 30214616 Ref: The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p. PMID: 30266084 Ref: Hotair mediates tumorigenesis through recruiting EZH2 in colorectal cancer. PMID: 30362162 Ref: Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme. PMID: 30376874 |