Primary Site >> Pancreatic Cancer
Gene >> EPHB2
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Ref: A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice. PMID: 10353601 Ref: Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression. PMID: 10402237 |
Ref: Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease. PMID: 10632533 Ref: Neurotensin-mediated activation of MAPK pathways and AP-1 binding in the human pancreatic cancer cell line, MIA PaCa-2. PMID: 10720480 Ref: TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation. PMID: 11002426 |
Ref: A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. PMID: 11159909 Ref: Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. PMID: 11162624 Ref: MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1. PMID: 11401480 Ref: cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. PMID: 11444827 Ref: Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines. PMID: 11522750 Ref: Integrin-mediated differentiation of a pancreatic carcinoma cell line is independent of FAK or MAPK activation levels. PMID: 11590318 Ref: 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. PMID: 11745456 |
Ref: Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases. PMID: 12014623 Ref: Heterotopic implantation alters the regulation of apoptosis and the cell cycle and generates a new metastatic site in a human pancreatic tumor xenograft model. PMID: 12087058 Ref: Dominant negative MEKK1 inhibits survival of pancreatic cancer cells. PMID: 12185592 Ref: Novel protein kinases in pancreatic cell growth and cancer. PMID: 12622411 |
Ref: Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis. PMID: 12712434 Ref: Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1. PMID: 12750255 Ref: Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. PMID: 12759238 Ref: Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. PMID: 12799645 Ref: Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK. PMID: 12902401 Ref: Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma. PMID: 12910515 Ref: CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). PMID: 14613031 Ref: p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth. PMID: 14613582 Ref: Multiple signal pathways are involved in the mitogenic effect of 5(S)-HETE in human pancreatic cancer. PMID: 14707447 Ref: Invasion-Metastasis by Hepatocyte Growth Factor/c-Met Signaling Concomitant with Induction of Urokinase Plasminogen Activator in Human Pancreatic Cancer: Role as Therapeutic Target. PMID: 26680937 |
Ref: Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1. PMID: 14732924 Ref: Involvement of p38 mitogen-activated protein kinase in gemcitabine-induced apoptosis in human pancreatic cancer cells. PMID: 15003513 Ref: Activation and role of MAP kinases in 15d-PGJ2-induced apoptosis in the human pancreatic cancer cell line MIA PaCa-2. PMID: 15028947 Ref: Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine. PMID: 15073105 Ref: KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. PMID: 15300592 Ref: Molecular targeting therapy for pancreatic cancer. PMID: 15316751 |
Ref: Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases. PMID: 15805288 Ref: Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1. PMID: 15969750 Ref: LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways. PMID: 16105664 Ref: Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway. PMID: 16311341 |
Ref: Galectin-1 induces chemokine production and proliferation in pancreatic stellate cells. PMID: 16373424 Ref: Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. PMID: 16507911 Ref: MUC5AC mucin gene regulation in pancreatic cancer cells. PMID: 16773182 Ref: Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma. PMID: 16788754 Ref: Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas. PMID: 16874861 Ref: Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. PMID: 16969513 Ref: Characterization of the CXCR4 signaling in pancreatic cancer cells. PMID: 18175225 |
Ref: BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. PMID: 17097223 Ref: Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. PMID: 17311308 Ref: Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. PMID: 17312387 Ref: Pancreatic cancer epidermal growth factor receptor (EGFR) intron 1 polymorphism influences postoperative patient survival and in vitro erlotinib response. PMID: 17453292 Ref: Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. PMID: 17569628 Ref: Flesh and blood: the story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies. PMID: 17590270 Ref: RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. PMID: 17638924 Ref: Neurotensin is a versatile modulator of in vitro human pancreatic ductal adenocarcinoma cell (PDAC) migration. PMID: 17641415 Ref: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. PMID: 17671195 Ref: Expression of connective tissue growth factor in pancreatic cancer cell lines. PMID: 17786299 Ref: Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. PMID: 17879119 Ref: Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit. PMID: 17942900 Ref: EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients. PMID: 17950068 Ref: Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system. PMID: 17950526 Ref: Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotop PMID: 17975158 Ref: Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. PMID: 18481199 |
Ref: EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. PMID: 17981559 Ref: GABA B receptor is a novel drug target for pancreatic cancer. PMID: 18098271 Ref: Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis. PMID: 18254976 Ref: Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. PMID: 18307536 Ref: Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase. PMID: 18316782 Ref: PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas. PMID: 18343945 Ref: Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. PMID: 18349319 Ref: Ras-driven transformation of human nestin-positive pancreatic epithelial cells. PMID: 18374182 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis. PMID: 18445520 Ref: SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. PMID: 18514780 Ref: Erythropoietin enhancement of rat pancreatic tumor cell proliferation requires the activation of ERK and JNK signals. PMID: 18550701 Ref: Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis. PMID: 18847491 Ref: Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes. PMID: 19001434 Ref: New treatment options for advanced pancreatic cancer. PMID: 19072345 |
Ref: Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling. PMID: 18805632 Ref: Death of a tumor: targeting CCN in pancreatic cancer. PMID: 19267221 Ref: Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. PMID: 19285010 Ref: Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines. PMID: 19288493 Ref: Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. PMID: 19433314 Ref: Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells. PMID: 19513748 Ref: A novel strategy for advanced pancreatic cancer - progression of molecular targeting therapy. PMID: 19538163 Ref: Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. PMID: 19549704 Ref: [Effect of icogenin on and its mechanism in anti-metastasis of pancreatic cancer BxPC3 cells]. PMID: 19618718 Ref: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. PMID: 19671674 Ref: Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models. PMID: 20009539 Ref: [Over-expression of caveolin-1 inhibits proliferation and invasion of pancreatic carcinoma cells in vitro]. PMID: 20021823 |
Ref: Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways. PMID: 19820417 Ref: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. PMID: 19820419 Ref: Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells. PMID: 20031158 Ref: Activation of EGFR by proteasome inhibition requires HB-EGF in pancreatic cancer cells. PMID: 20208558 Ref: Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. PMID: 20301194 Ref: Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. PMID: 20331621 Ref: Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. PMID: 20419833 Ref: In vitro and in vivo antitumor efficacy of docetaxel and sorafenib combination in human pancreatic cancer cells. PMID: 20491617 Ref: Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma. PMID: 20499280 Ref: AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling. PMID: 20581862 Ref: Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies. PMID: 20630061 Ref: Infrequent methylation of the DUSP6 phosphatase in endometrial cancer. PMID: 20638106 Ref: Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. PMID: 20642839 Ref: MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells. PMID: 20669973 Ref: Synergistic cytotoxicity and molecular interaction on drug targets of sorafenib and gemcitabine in human pancreas cancer cells. PMID: 20714148 Ref: Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis. PMID: 20717927 Ref: Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer. PMID: 20726858 Ref: Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. PMID: 20838624 Ref: Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. PMID: 20858281 Ref: The induction of S100p expression by the Prostaglandin E(2) (PGE(2))/EP4 receptor signaling pathway in colon cancer cells. PMID: 20890108 Ref: Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with rapamycin in human orthotopic primary pancreatic cancer xenografts. PMID: 20920162 Ref: PRSS3 promotes tumour growth and metastasis of human pancreatic cancer. PMID: 20947888 Ref: TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. PMID: 21044336 Ref: CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. PMID: 21045835 |
Ref: Cytotoxic responses to N-(4-hydroxyphenyl)retinamide in human pancreatic cancer cells. PMID: 21072519 Ref: Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells. PMID: 21196815 Ref: Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells. PMID: 21219855 Ref: Combined blockade of Src kinase and epidermal growth factor receptor with gemcitabine overcomes STAT3-mediated resistance of inhibition of pancreatic tumor growth. PMID: 21266529 Ref: Pancreatic cancer cells respond to type I collagen by inducing snail expression to promote membrane type 1 matrix metalloproteinase-dependent collagen invasion. PMID: 21288898 Ref: Promoted cancer growth by stimulating cell proliferation and decreasing apoptosis using a lentivirus-based EphB2 RNAi in pancreatic carcinoma CFPAC-1 cells. PMID: 21292437 Ref: Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. PMID: 21678117 Ref: Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway. PMID: 21723941 Ref: Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer. PMID: 21795855 Ref: Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors. PMID: 21980390 Ref: Dickkopf3 overexpression inhibits pancreatic cancer cell growth in vitro. PMID: 21987623 Ref: DeltaNp63alpha-mediated induction of epidermal growth factor receptor promotes pancreatic cancer cell growth and chemoresistance. PMID: 22053213 Ref: Mechanisms underlying gemcitabine resistance in pancreatic cancer and sensitisation by the iMiD lenalidomide. PMID: 22110196 |
Ref: Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. PMID: 21852217 Ref: Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression. PMID: 22041919 Ref: Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. PMID: 22072614 Ref: Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors alpha3, alpha5, and alpha7. PMID: 22188668 Ref: VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. PMID: 22207048 Ref: RAS oncogenic signal upregulates EZH2 in pancreatic cancer. PMID: 22222375 Ref: Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma. PMID: 22222635 Ref: Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice. PMID: 22287227 Ref: Beta-adrenoceptor action on pancreatic cancer cell proliferation and tumor growth in mice. PMID: 22353526 Ref: Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma. PMID: 22440084 Ref: Nicotine, IFN-gamma and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades. PMID: 22537161 Ref: Combined effects of EGFR and Hedgehog signaling pathway inhibition on the proliferation and apoptosis of pancreatic cancer cells. PMID: 22581058 Ref: BMP2 induces PANC-1 cell invasion by MMP-2 overexpression through ROS and ERK. PMID: 22652796 Ref: Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer. PMID: 22761868 Ref: Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation. PMID: 22782341 Ref: Overexpression of the B-type Eph and ephrin genes correlates with progression and pain in human pancreatic cancer. PMID: 22783419 Ref: Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters. PMID: 22791813 Ref: Novel agents and new combination treatments on phase I studies on solid tumors and pancreatic cancer. PMID: 22797386 Ref: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. PMID: 22833572 Ref: Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. PMID: 22900040 Ref: Reversal of multidrug resistance by gefitinib via RAF1/ERK pathway in pancreatic cancer cell line. PMID: 22907845 Ref: Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice. PMID: 22916251 Ref: [Effects and mechanisms of combined suppression of epidermal growth factor receptor and hedgehog signaling on proliferation in pancreatic cancer cells]. PMID: 22944238 Ref: CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB: implications for bidirectional tumor-stromal interactions. PMID: 22995914 Ref: Novel involvement of leukotriene B(4) receptor 2 through ERK activation by PP2A down-regulation in leukotriene B(4)-induced keratin phosphorylation and reorganization of pancreatic cancer cells. PMID: 23017243 Ref: MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance. PMID: 23205101 |
Ref: EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin. PMID: 22971992 Ref: Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells. PMID: 23340175 Ref: Vitamin E delta-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. PMID: 23393547 Ref: Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. PMID: 23437362 Ref: Metformin inhibits the growth of human pancreatic cancer xenografts. PMID: 23462329 Ref: Enhancing sorafenib-mediated sensitization to gemcitabine in experimental pancreatic cancer through EMAP II. PMID: 23497499 Ref: Proliferation enhanced by NGF-NTRK1 signaling makes pancreatic cancer cells more sensitive to 2DG-induced apoptosis. PMID: 23569426 Ref: Direct TGF-beta1 signaling between activated platelets and pancreatic cancer cells primes cisplatin insensitivity. PMID: 23584798 Ref: Transforming growth factor-alpha activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation. PMID: 23608755 Ref: Low concentrations of metformin selectively inhibit CD133(+) cell proliferation in pancreatic cancer and have anticancer action. PMID: 23667692 Ref: Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1. PMID: 23762360 Ref: miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. PMID: 23831622 Ref: alpha-Mangostin suppresses lipopolysaccharide-induced invasion by inhibiting matrix metalloproteinase-2/9 and increasing E-cadherin expression through extracellular signal-regulated kinase signaling in pancreatic cancer cells. PMID: 23833675 Ref: Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi). PMID: 23922886 Ref: Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer. PMID: 24025152 Ref: Quinazolino linked 4beta-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation. PMID: 24055291 Ref: Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. PMID: 24097820 Ref: Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC). PMID: 24330423 Ref: The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells. PMID: 24392017 |
Ref: Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration. PMID: 23625726 Ref: microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-beta actions. PMID: 24096486 Ref: Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells. PMID: 24215674 Ref: Overexpression of calreticulin contributes to the development and progression of pancreatic cancer. PMID: 24264800 Ref: Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. PMID: 24297112 Ref: Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth. PMID: 24371225 Ref: [Mechanism underlying pancreatic cancer cell resistance to mTOR inhibitor RAD001 via c-Raf/ERK1/2 activation]. PMID: 24405594 Ref: Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency. PMID: 24519751 Ref: Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma. PMID: 24568222 Ref: A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases. PMID: 24634378 Ref: Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer. PMID: 24720336 Ref: The Activation of beta1-integrin by Type I Collagen Coupling with the Hedgehog Pathway Promotes the Epithelial-Mesenchymal Transition in Pancreatic Cancer. PMID: 24720337 Ref: Polyserase-1/TMPRSS9 induces pro-tumor effects in pancreatic cancer cells by activation of pro-uPA. PMID: 24756697 Ref: Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. PMID: 24785258 Ref: PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling. PMID: 24788754 Ref: HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer. PMID: 24819705 Ref: Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice. PMID: 24853419 Ref: High expression of erythropoietin-producing hepatoma cell line-B2 (EphB2) predicts the efficiency of the Qingyihuaji formula treatment in pancreatic cancer CFPAC-1 cells through the EphrinB1-EphB2 pathway. PMID: 24959213 Ref: Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer. PMID: 24975163 Ref: Co-treatment with panitumumab and trastuzumab augments response to the MEK inhibitor trametinib in a patient-derived xenograft model of pancreatic cancer. PMID: 25117978 Ref: Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice. PMID: 25127677 Ref: Crizotinib exhibits antitumor activity by targeting ALK signaling not c-MET in pancreatic cancer. PMID: 25193856 Ref: Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity. PMID: 25216706 Ref: p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-kappaB pathway. PMID: 25238288 Ref: Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro. PMID: 25260978 Ref: Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway. PMID: 25304374 Ref: Cholinergic receptors as target for cancer therapy in a systems medicine perspective. PMID: 25324001 Ref: RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer. PMID: 25341034 Ref: Effects of insulin on human pancreatic cancer progression modeled in vitro. PMID: 25373319 Ref: Anticancer effects of metformin on neuroendocrine tumor cells in vitro. PMID: 25402373 Ref: Dynamic distribution of ERK, p38 and JNK during the development of pancreatic ductal adenocarcinoma. PMID: 25440531 Ref: Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. PMID: 25493642 Ref: Effect of DAPK1 gene on proliferation, migration, and invasion of carcinoma of pancreas BxPC-3 cell line. PMID: 25550789 |
Ref: Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. PMID: 25065594 Ref: CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer. PMID: 25318601 Ref: Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway. PMID: 25409929 Ref: Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways. PMID: 25418891 Ref: The glucosylceramide synthase inhibitor PDMP sensitizes pancreatic cancer cells to MEK/ERK inhibitor AZD-6244. PMID: 25498501 Ref: A preclinical evaluation of SKLB261, a multikinase inhibitor of EGFR/Src/VEGFR2, as a therapeutic agent against pancreatic cancer. PMID: 25519702 Ref: The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer. PMID: 25557115 Ref: Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1alpha pathway to predict survival in resectable pancreatic cancer. PMID: 25584484 Ref: Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-theta activation. PMID: 25638159 Ref: MicroRNA-410 functions as a tumor suppressor by targeting angiotensin II type 1 receptor in pancreatic cancer. PMID: 25646808 Ref: Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2. PMID: 25673820 Ref: Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-kappaB pathway. PMID: 25690319 Ref: Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-Based Method. PMID: 25724428 Ref: ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. PMID: 25753158 Ref: Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor. PMID: 25766633 Ref: Superoxide dismutase promotes the epithelial-mesenchymal transition of pancreatic cancer cells via activation of the H2O2/ERK/NF-kappaB axis. PMID: 25825208 Ref: Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors. PMID: 25886138 Ref: A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion. PMID: 25915428 Ref: LIM-only protein FHL2 critically determines survival and radioresistance of pancreatic cancer cells. PMID: 25917075 Ref: Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells. PMID: 26035354 Ref: Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. PMID: 26043686 Ref: Cantharidin represses invasion of pancreatic cancer cells through accelerated degradation of MMP2 mRNA. PMID: 26135631 Ref: The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy in Pancreatic Cancer Models by Altering Ribonucleotide Reductase Subunit-1 (RRM1). PMID: 26228206 Ref: Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells. PMID: 26257206 Ref: Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation. PMID: 26260159 Ref: Expression of CD44 in pancreatic cancer and its significance. PMID: 26261555 Ref: The Antipancreatic Cancer Activity of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2. PMID: 26284306 Ref: Novel agents for advanced pancreatic cancer. PMID: 26369833 Ref: Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling. PMID: 26391180 Ref: The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine. PMID: 26397991 Ref: Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer. PMID: 26439801 Ref: The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-kappaB and RalB signaling pathways. PMID: 26477488 Ref: Trametinib and dactolisib but not regorafenib exert antiproliferative effects on rat pancreatic stellate cells. PMID: 26663013 |
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Ref: IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells. PMID: 27435400 Ref: Smyd3-associated regulatory pathways in cancer. PMID: 27554136 Ref: Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells. PMID: 27891679 Ref: ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. PMID: 28025100 Ref: The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways. PMID: 28052097 Ref: HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway. PMID: 28077929 Ref: Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma. 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PMID: 28893319 Ref: The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. PMID: 28912272 Ref: Baicalein inhibits pancreatic cancer cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and ERK signaling pathways. PMID: 28915595 Ref: NEMO peptide inhibits the growth of pancreatic ductal adenocarcinoma by blocking NF-kappaB activation. PMID: 28951128 Ref: Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. PMID: 29066484 Ref: Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells. PMID: 29069737 Ref: Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway. 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Ref: Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis. PMID: 28916526 Ref: Exosomes derived from pancreatic cancer cells induce activation and profibrogenic activities in pancreatic stellate cells. PMID: 29111329 Ref: KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK-ERK pathway in pancreatic cancer. PMID: 29315556 Ref: Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells Investigated via Large-Scale, Ion-Current-Based Quantitative Proteomics (IonStar). PMID: 29358341 Ref: p38 differentially regulates ERK, p21, and mitogenic signalling in two pancreatic carcinoma cell lines. PMID: 29380233 Ref: The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling. 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PMID: 29702094 Ref: Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. PMID: 29709702 Ref: Inhibition of interleukin 8/CX-C chemokine receptor 1,/2 signaling reduces malignant features in human pancreatic cancer cells. PMID: 29749433 Ref: A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology. PMID: 29757973 Ref: Surgical treatment of pancreatic cancer. PMID: 29773761 Ref: Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-beta1/FAK/ERK pathway. PMID: 29777904 Ref: In vivo reprogramming drives Kras-induced cancer development. PMID: 29802314 Ref: MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells. 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