Primary Site >> Liver Cancer
Gene >> EPHB2
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Ref: Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma. PMID: 8227358 |
Ref: Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. PMID: 9537433 |
Ref: Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. PMID: 11050045 Ref: Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. PMID: 11156183 |
Ref: Genetic and epigenetic events in human hepatocarcinogenesis. PMID: 11351262 Ref: Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? PMID: 11431335 Ref: Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. PMID: 11532983 Ref: High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2. PMID: 11533045 Ref: Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo. PMID: 11581403 |
Ref: Coexpression of ephrin-Bs and their receptors in colon carcinoma. PMID: 11920461 Ref: Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway. PMID: 12209735 |
Ref: Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. PMID: 12692057 Ref: An absolute role of the PKC-dependent NF-kappaB activation for induction of MMP-9 in hepatocellular carcinoma cells. PMID: 12745093 Ref: Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor. PMID: 12763374 Ref: Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis. PMID: 14675712 |
Ref: Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. PMID: 14726470 Ref: Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. PMID: 14992744 Ref: Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. PMID: 15033934 Ref: Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. PMID: 15037655 Ref: Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. PMID: 15132991 Ref: Histone-deacetylase inhibitors induce the cathelicidin LL-37 in gastrointestinal cells. PMID: 15261456 Ref: Disruption of hepatocellular tight junctions by vascular endothelial growth factor (VEGF): a novel mechanism for tumor invasion. PMID: 15288477 Ref: Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines. PMID: 15298730 Ref: Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1. PMID: 15349900 Ref: Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells. PMID: 15464233 Ref: Overexpression of extracellular signal-regulated protein kinase and its correlation with proliferation in human hepatocellular carcinoma. PMID: 15482339 Ref: Extracellular signal-regulated kinase induces cyclin D1 and Cdk-2 expression and phosphorylation of retinoblastoma in hepatocellular carcinoma. PMID: 15547725 Ref: Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. PMID: 15632311 |
Ref: Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway. PMID: 15534860 Ref: Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. PMID: 15613696 Ref: Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells. PMID: 15661807 Ref: Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA, involves multiple signal transduction pathways. PMID: 15797241 Ref: Novel hydroxyl naphthoquinones with potent Cdc25 antagonizing and growth inhibitory properties. PMID: 15827333 Ref: Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. PMID: 15878354 Ref: Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase. PMID: 15910736 Ref: Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2. PMID: 15917995 Ref: Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. PMID: 15941563 Ref: Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. PMID: 16014626 Ref: Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. PMID: 16039586 Ref: PE, a new sulfated saponin from sea cucumber, exhibits anti-angiogenic and anti-tumor activities in vitro and in vivo. PMID: 16082187 Ref: [Effect of HBV X gene transfection on octreotide-inhibited growth of hepatocellular carcinoma cell line HepG2]. PMID: 16086874 Ref: DNA damage and G2/M arrest in Syrian hamster embryo cells during Malachite green exposure are associated with elevated phosphorylation of ERK1 and JNK1. PMID: 16297712 |
Ref: Enhancement of esculetin on Taxol-induced apoptosis in human hepatoma HepG2 cells. PMID: 16051289 Ref: Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). PMID: 16112786 Ref: Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. PMID: 16169661 Ref: Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals. PMID: 16322093 Ref: Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. PMID: 16327976 Ref: Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. PMID: 16458870 Ref: Sprouty and cancer: the first terms report. PMID: 16469433 Ref: The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer. PMID: 16533420 Ref: Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. PMID: 16564107 Ref: Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB. PMID: 16581947 Ref: Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. PMID: 16757355 Ref: SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma. PMID: 16762634 Ref: [Hepatocyte-specific Pten deficient mice]. PMID: 16768106 Ref: The binding between p67 and eukaryotic initiation factor 2 plays important roles in the protection of eIF2alpha from phosphorylation by kinases. PMID: 16843428 Ref: Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma. PMID: 16865242 Ref: Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK. PMID: 16930563 Ref: Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. PMID: 17030190 Ref: Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells. PMID: 17202857 |
Ref: Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. PMID: 17154373 Ref: Survival and apoptosis: a dysregulated balance in liver cancer. PMID: 17311609 Ref: Thrombin-mediated hepatocellular carcinoma cell migration: cooperative action via proteinase-activated receptors 1 and 4. PMID: 17323377 Ref: MEK/ERK-dependent uPAR expression is required for motility via phosphorylation of P70S6K in human hepatocarcinoma cells. PMID: 17427199 Ref: Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione. PMID: 17464209 Ref: Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis. PMID: 17512084 Ref: Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. PMID: 17611410 Ref: MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. PMID: 17673346 Ref: Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. PMID: 17708250 Ref: Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. PMID: 17717605 Ref: Laminin-5 stimulates hepatocellular carcinoma growth through a different function of alpha6beta4 and alpha3beta1 integrins. PMID: 17948258 Ref: [The role of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance of hepatocellular carcinoma]. PMID: 17953842 Ref: Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia. PMID: 17961496 Ref: Molecular pathways and related target therapies in liver carcinoma. PMID: 18045179 Ref: Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. PMID: 18424914 |
Ref: Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway. PMID: 17574577 Ref: Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. PMID: 17599042 Ref: siRNA mediated the type 1 insulin-like growth factor receptor and epidermal growth factor receptor silencing induces chemosensitization of liver cancer cells. PMID: 17901981 Ref: NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. PMID: 17964630 Ref: Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. PMID: 17991769 Ref: Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. PMID: 17996228 Ref: Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. PMID: 17998146 Ref: Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation. PMID: 18004740 Ref: Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. PMID: 18158318 Ref: EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells. PMID: 18164805 Ref: Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model. PMID: 18297306 Ref: Sorafenib, a systemic therapy for hepatocellular carcinoma. PMID: 18376365 Ref: Synergistic growth inhibition by 9-cis-retinoic acid plus trastuzumab in human hepatocellular carcinoma cells. PMID: 18451248 Ref: The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCC. PMID: 18468633 Ref: Failure of lamivudine to reverse hepatitis B virus-associated changes in ERK, Akt and cell cycle regulatory proteins. PMID: 18505173 Ref: Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells. PMID: 18651222 Ref: ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. PMID: 18651980 Ref: Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control. PMID: 18697198 Ref: Review article: pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents. PMID: 18808443 Ref: [Coadministration of sorafenib and cisplatin inhibits proliferation of hepatocellular carcinoma HepG2 cells in vitro]. PMID: 18819900 Ref: Cellular mechanisms of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MAPK signaling in hepatocellular carcinoma. PMID: 18822689 Ref: Expression of CD147 mediates tumor cells invasion and multidrug resistance in hepatocellular carcinoma. PMID: 19093255 |
Ref: Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival. PMID: 19001362 Ref: Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis. PMID: 19009564 Ref: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. PMID: 19148542 Ref: Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. PMID: 19220580 Ref: Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells. PMID: 19258520 Ref: Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor. PMID: 19293637 Ref: Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo. PMID: 19376607 Ref: Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. PMID: 19399925 Ref: Inhibitory effect of immature plum on PMA-induced MMP-9 expression in human hepatocellular carcinoma. PMID: 19418353 Ref: Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells. PMID: 19424594 Ref: Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma. PMID: 19429855 Ref: Expression of phospho-ERK1/2 and PI3-K in benign and malignant gallbladder lesions and its clinical and pathological correlations. PMID: 19445727 Ref: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. PMID: 19472191 Ref: Comparative transcriptome and proteome analysis of Ha-ras and B-raf mutated mouse liver tumors. PMID: 19476384 Ref: Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells. PMID: 19520494 Ref: (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. PMID: 19558547 Ref: Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue. PMID: 19639210 Ref: Phosphorylated ERK is a potential predictor of sensitivity to sorafenib when treating hepatocellular carcinoma: evidence from an in vitro study. PMID: 19698189 Ref: Role of prosurvival molecules in the action of lidamycin toward human tumor cells. PMID: 19725468 Ref: Rhein lysinate suppresses the growth of tumor cells and increases the anti-tumor activity of Taxol in mice. PMID: 19885952 |
Ref: Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line. PMID: 19685055 Ref: Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus. PMID: 19786052 Ref: AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC). PMID: 19910069 Ref: Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. PMID: 19929904 Ref: Targeted therapy of hepatocellular cancer. PMID: 20074016 Ref: AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma. PMID: 20101735 Ref: Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2. PMID: 20170530 Ref: Prognostic markers and putative therapeutic targets for hepatocellular carcinoma. PMID: 20176048 Ref: Molecular genetics of hepatocellular neoplasia. PMID: 20182587 Ref: Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib. PMID: 20300004 Ref: Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. PMID: 20345479 Ref: Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells. PMID: 20349911 Ref: Molecularly targeted therapy in hepatocellular carcinoma. PMID: 20371362 Ref: Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species. PMID: 20443032 Ref: PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells. PMID: 20444294 Ref: Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old. PMID: 20540791 Ref: miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. PMID: 20624000 Ref: 3'-Sulfo-Le(x) is important for regulation of integrin subunit alphaV. PMID: 20695481 Ref: PEBP1 downregulation is associated to poor prognosis in HCC related to hepatitis B infection. PMID: 20739083 Ref: Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells. PMID: 20800650 Ref: Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. PMID: 20842425 Ref: C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line. PMID: 20858479 Ref: Cisplatin induces programmed death-1-ligand 1(PD-L1) over-expression in hepatoma H22 cells via Erk /MAPK signaling pathway. PMID: 20937224 Ref: PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. PMID: 21187475 Ref: [Cross-talk between PI3K/Akt and MEK/ERK pathways regulates human hepatocellular carcinoma cell cycle progression under endoplasmic reticulum stress]. PMID: 21205476 Ref: Hepatoma-derived growth factor regulates the bad-mediated apoptotic pathway and induction of vascular endothelial growth factor in stomach cancer cells. PMID: 21302807 |
Ref: Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells. PMID: 20133117 Ref: Effects of siRNA-targeting BMP-2 on the abilities of migration and invasion of human liver cancer SMMC7721 cells and its mechanism. PMID: 20885449 Ref: Mitogen-activated protein kinases in hepatocellular carcinoma development. PMID: 20969960 Ref: Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice. PMID: 21071580 Ref: Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. PMID: 21128229 Ref: Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. PMID: 21145824 Ref: Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III. PMID: 21163950 Ref: Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. PMID: 21258214 Ref: [Relative analysis of OPN and its related signal molecules in hepatocellular carcinoma]. PMID: 21272459 Ref: Effect of sorafenib on murine liver regeneration. PMID: 21274878 Ref: The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-beta-induced apoptosis of liver tumor cells. PMID: 21276422 Ref: Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice. PMID: 21372039 Ref: RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway. PMID: 21391225 Ref: Hepatic stellate cells stimulate HCC cell migration via laminin-5 production. PMID: 21413933 Ref: Trichostatin A sensitizes HBx-expressing liver cancer cells to etoposide treatment. PMID: 21468663 Ref: Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice. PMID: 21513518 Ref: Blockade of IGF-IR exerts anticancer effects in hepatocellular carcinoma. PMID: 21567089 Ref: ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways. PMID: 21621522 Ref: Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism. PMID: 21628989 Ref: Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation. PMID: 21630638 Ref: Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral assembly. PMID: 21653755 Ref: DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma. PMID: 21660063 Ref: Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism. PMID: 21703232 Ref: Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. PMID: 21718361 Ref: A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish. PMID: 21729876 Ref: Suppression by heat shock protein 20 of hepatocellular carcinoma cell proliferation via inhibition of the mitogen-activated protein kinases and AKT pathways. PMID: 21769911 Ref: Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways. PMID: 21770460 Ref: Alcohol induces liver neoplasia in a novel alcohol-preferring rat model. PMID: 21790668 Ref: Chebulagic acid synergizes the cytotoxicity of doxorubicin in human hepatocellular carcinoma through COX-2 dependant modulation of MDR-1. PMID: 21801152 Ref: The role of innate immunity in the pathogenesis of preneoplasia in drug-induced chronic hepatitis based on a mouse model. PMID: 21820428 Ref: Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells. PMID: 21829603 Ref: Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2. PMID: 21842414 Ref: [Expression of Raf kinase inhibitor protein and its significance in invasion and metastasis of hepatocellular carcinoma]. PMID: 21875465 Ref: Effective inhibition of a Strongylocentrotus nudus eggs polysaccharide against hepatocellular carcinoma is mediated via immunoregulation in vivo. PMID: 21893096 Ref: Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. PMID: 21957142 Ref: Role of Raf Kinase Inhibitor Protein in Hepatocellular Carcinoma. PMID: 21984963 Ref: Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro. PMID: 22088142 Ref: Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma. PMID: 22110214 Ref: Novel EGFR-TK inhibitor EKB-569 inhibits hepatocellular carcinoma cell proliferation by AKT and MAPK pathways. PMID: 22147992 Ref: Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PMID: 22216150 |
Ref: Regulatory mechanisms of interleukin-8 production induced by tumour necrosis factor-alpha in human hepatocellular carcinoma cells. PMID: 21545687 Ref: Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK. PMID: 21617941 Ref: Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish. PMID: 21888874 Ref: An inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. PMID: 21903676 Ref: BMP activated Smad signaling strongly promotes migration and invasion of hepatocellular carcinoma cells. PMID: 22024355 Ref: PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation. PMID: 22261591 Ref: Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells. PMID: 22314224 Ref: Tanshinone IIA inhibits BT-20 human breast cancer cell proliferation through increasing caspase 12, GADD153 and phospho-p38 protein expression. PMID: 22322382 Ref: Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells. PMID: 22349030 Ref: Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway. PMID: 22425622 Ref: Activation of PI3K/AKT and MAPK pathway through a PDGFRbeta-dependent feedback loop is involved in rapamycin resistance in hepatocellular carcinoma. PMID: 22428038 Ref: Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma. PMID: 22484587 Ref: In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells. PMID: 22554586 Ref: Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress. PMID: 22555451 Ref: Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand. PMID: 22579649 Ref: Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells. PMID: 22580126 Ref: DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. PMID: 22593025 Ref: Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma. PMID: 22596232 Ref: Effect of environmental factors on chemoresistance of HepG2 cells by regulating hypoxia-inducible factor-1alpha. PMID: 22613537 Ref: DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma. PMID: 22614672 Ref: Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation. PMID: 22618858 Ref: Combined anti-tumor effects of IFN-alpha and sorafenib on hepatocellular carcinoma in vitro and in vivo. PMID: 22634008 Ref: Erlotinib and sorafenib in an orthotopic rat model of hepatocellular carcinoma. PMID: 22634341 Ref: Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling. PMID: 22684543 Ref: Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. PMID: 22687285 Ref: The role of PI3K/mTOR inhibition in combination with sorafenib in hepatocellular carcinoma treatment. PMID: 22753710 Ref: Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo. PMID: 22761917 Ref: Effect of insulin-like growth factor-1 on bone morphogenetic protein-2 expression in hepatic carcinoma SMMC7721 cells through the p38 MAPK signaling pathway. PMID: 22799302 Ref: HGFK1 is associated with a better prognosis and reverses inhibition by gefitinib in NSCLC cases. PMID: 22799348 Ref: SD118-xanthocillin X (1), a novel marine agent extracted from Penicillium commune, induces autophagy through the inhibition of the MEK/ERK pathway. PMID: 22822377 Ref: Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. PMID: 22927446 Ref: CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability. PMID: 22964005 Ref: Dissimilar immunohistochemical expression of ERK and AKT between paired biopsy and hepatectomy tissues of hepatocellular carcinoma. PMID: 23155253 Ref: The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3K/Akt pathway. PMID: 23300578 Ref: Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison. PMID: 23393659 |
Ref: Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver. PMID: 22477361 Ref: HDGF-related protein-3 is required for anchorage-independent survival and chemoresistance in hepatocellular carcinomas. PMID: 22490522 Ref: The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation. PMID: 22749133 Ref: Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. PMID: 22777740 Ref: Targeting tyrosine kinase receptors in hepatocellular carcinoma. PMID: 23016985 Ref: MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells. PMID: 23042098 Ref: Claudin-1 induces epithelial-mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells. PMID: 23160379 Ref: Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition. PMID: 23229794 Ref: Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells. PMID: 23248036 Ref: Claudin-1 as a promoter of EMT in hepatocellular carcinoma. PMID: 23318416 Ref: MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. PMID: 23320839 Ref: Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis. PMID: 23321675 Ref: Maraviroc, a CCR5 antagonist, prevents development of hepatocellular carcinoma in a mouse model. PMID: 23326556 Ref: The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. PMID: 23392177 Ref: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma. PMID: 23397142 Ref: MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor beta receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma. PMID: 23401231 Ref: Inhibitory effect of oleanolic acid on hepatocellular carcinoma via ERK-p53-mediated cell cycle arrest and mitochondrial-dependent apoptosis. PMID: 23404993 Ref: Suppression of natural killer cells by sorafenib contributes to prometastatic effects in hepatocellular carcinoma. PMID: 23409093 Ref: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo. PMID: 23448150 Ref: PTK787/ZK222584 combined with interferon alpha and 5-fluorouracil synergistically inhibits VEGF signaling pathway in hepatocellular carcinoma. PMID: 23508585 Ref: Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. PMID: 23537747 Ref: The blockage of Ras/ERK pathway augments the sensitivity of SphK1 inhibitor SKI II in human hepatoma HepG2 cells. PMID: 23545258 Ref: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model. PMID: 23563852 Ref: Bis(acetylacetonato)-oxovanadium(iv), bis(maltolato)-oxovanadium(iv) and sodium metavanadate induce antilipolytic effects by regulating hormone-sensitive lipase and perilipin via activation of Akt. PMID: 23576171 Ref: Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors. 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PMID: 26316083 Ref: Hexane extract from Sargassum serratifolium inhibits the cell proliferation and metastatic ability of human glioblastoma U87MG cells. PMID: 26323587 Ref: DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1. PMID: 26362312 Ref: GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinoma. PMID: 26378040 Ref: Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Kappab P65 and Wnt/Beta-Catenin in Vitro. PMID: 26404320 Ref: Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma. PMID: 26547929 Ref: Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. 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PMID: 26982332 Ref: MicroRNA-630 suppresses tumor metastasis through the TGF-beta- miR-630-Slug signaling pathway and correlates inversely with poor prognosis in hepatocellular carcinoma. PMID: 26993767 Ref: Giganteaside D induces ROS-mediated apoptosis in human hepatocellular carcinoma cells through the MAPK pathway. PMID: 27016209 Ref: A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. PMID: 27023566 Ref: Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3. PMID: 27029030 Ref: FGFR3 promotes angiogenesis-dependent metastasis of hepatocellular carcinoma via facilitating MCP-1-mediated vascular formation. PMID: 27044356 Ref: Up-regulated expression of phospholipase C, beta1 is associated with tumor cell proliferation and poor prognosis in hepatocellular carcinoma. PMID: 27051304 Ref: Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells. 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PMID: 27196749 Ref: EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. PMID: 27244890 Ref: Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma. PMID: 27267910 Ref: Hepatoma-derived growth factor promotes growth and metastasis of hepatocellular carcinoma cells. PMID: 27273265 Ref: Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo. PMID: 27278720 Ref: Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin. PMID: 27326258 Ref: NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance. PMID: 27336713 Ref: Hepatocellular carcinoma: Exploring the impact of ethnicity on molecular biology. 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PMID: 27530187 Ref: Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis. PMID: 27556180 Ref: STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling. PMID: 27628214 Ref: Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. PMID: 27654866 Ref: Inhibition of eukaryotic initiation factor 4E phosphorylation by cercosporamide selectively suppresses angiogenesis, growth and survival of human hepatocellular carcinoma. PMID: 27662474 Ref: The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals. PMID: 27688096 Ref: delta and gamma tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling. PMID: 27713963 Ref: Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma. PMID: 27734263 Ref: Phosphorylation of PPARgamma at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4. PMID: 27769068 Ref: Glycosylation patterns and PHA-E-associated glycoprotein profiling associated with early hepatic encephalopathy in Chinese hepatocellular carcinoma patients. PMID: 27830009 Ref: Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling. PMID: 27835898 Ref: ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. PMID: 27846390 Ref: The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line. PMID: 27847436 Ref: Endothelial progenitor cell number and ERK phosphorylation serve as predictive and prognostic biomarkers in advanced hepatocellular carcinoma patients treated with sorafenib. PMID: 27853648 Ref: Promotive effects of bone morphogenetic protein 2 on angiogenesis in hepatocarcinoma via multiple signal pathways. PMID: 27886213 Ref: Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression. PMID: 28018113 Ref: Grape Seed Extract Attenuates Hepatitis C Virus Replication and Virus-Induced Inflammation. PMID: 28066241 |
Ref: Smyd3-associated regulatory pathways in cancer. PMID: 27554136 Ref: Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. PMID: 27696512 Ref: Targeting Signalling Pathways in Hepatocellular Carcinoma. PMID: 27719638 Ref: Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury. PMID: 27748761 Ref: C2-ceramide enhances sorafenib-induced caspase-dependent apoptosis via PI3K/AKT/mTOR and Erk signaling pathways in HCC cells. PMID: 27807662 Ref: Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. PMID: 27899290 Ref: Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro. PMID: 28011478 Ref: Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells. PMID: 28012958 Ref: Alendronate-anchored PEGylation of ceria nanoparticles promotes human hepatoma cell proliferation via AKT/ERK signaling pathways. PMID: 28070935 Ref: Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma. PMID: 28073159 Ref: NMI promotes hepatocellular carcinoma progression via BDKRB2 and MAPK/ERK pathway. PMID: 28077802 Ref: ERK1 Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun Activity and Cell Transformation. PMID: 28106280 Ref: Mathematical modelling unveils the essential role of cellular phosphatases in the inhibition of RAF-MEK-ERK signalling by sorafenib in hepatocellular carcinoma cells. PMID: 28161506 Ref: Dual inhibition of Akt and c-Met as a second-line therapy following acquired resistance to sorafenib in hepatocellular carcinoma cells. PMID: 28164434 Ref: Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals. PMID: 28230260 Ref: Reduced N-acetylglucosaminyltransferase III expression via Smad3 and Erk signaling in TGF-beta1-induced HCC EMT model. PMID: 28245423 Ref: Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. PMID: 28276530 Ref: Mice lacking liver-specific beta-catenin develop steatohepatitis and fibrosis after iron overload. PMID: 28341391 Ref: Molecular mechanism of C-reaction protein in promoting migration and invasion of hepatocellular carcinoma cells in vitro. PMID: 28350119 Ref: Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. PMID: 28363167 Ref: GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. PMID: 28394926 Ref: The expression of fibronectin is significantly suppressed in macrophages to exert a protective effect against Staphylococcus aureus infection. PMID: 28407745 Ref: Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells. PMID: 28415690 Ref: HOXB7 promotes tumor progression via bFGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma. PMID: 28454092 Ref: Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson's disease on liver cancer. PMID: 28455267 Ref: The cell polarity protein Scrib functions as a tumor suppressor in liver cancer. PMID: 28460446 Ref: SHP2 is induced by the HBx-NF-kappaB pathway and contributes to fibrosis during human early hepatocellular carcinoma development. PMID: 28460481 Ref: Inhibition of ERK1/2 Signaling Impairs the Promoting Effects of TGF-beta1 on Hepatocellular Carcinoma Cell Invasion and Epithelial-Mesenchymal Transition. PMID: 28492136 Ref: Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway. PMID: 28506767 Ref: Differential Proteomic Analysis of Gender-dependent Hepatic Tumorigenesis in Hras12V Transgenic Mice. PMID: 28512230 Ref: Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. PMID: 28534824 Ref: Effects and related mechanisms of serotonin on malignant biological behavior of hepatocellular carcinoma via regulation of Yap. PMID: 28537892 Ref: Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma. PMID: 28545547 Ref: Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells. PMID: 28560380 Ref: Pentoxifylline induces apoptosis of HepG2 cells by reducing reactive oxygen species production and activating the MAPK signaling. PMID: 28583366 Ref: ERK pathway activation contributes to the tumor-promoting effects of hepatic stellate cells in hepatocellular carcinoma. PMID: 28668554 Ref: TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma. PMID: 28674078 Ref: Modulation of IGF2BP1 by long non-coding RNA HCG11 suppresses apoptosis of hepatocellular carcinoma cells via MAPK signaling transduction. PMID: 28677801 Ref: Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. PMID: 28698660 Ref: Increased matrix stiffness promotes tumor progression of residual hepatocellular carcinoma after insufficient heat treatment. PMID: 28699238 Ref: beta-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways. PMID: 28722351 Ref: MicroRNA-30a suppresses tumor progression by blocking Ras/Raf/MEK/ERK signaling pathway in hepatocellular carcinoma. PMID: 28732393 Ref: MicroRNA-374a Promotes Hepatocellular Carcinoma Cell Proliferation by Targeting Mitogen-Inducible Gene-6 (MIG-6). PMID: 28734040 Ref: Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. PMID: 28745317 Ref: Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. PMID: 28842424 Ref: The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. PMID: 28861175 Ref: 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol negatively regulates activation of STAT3 and ERK pathways and exhibits anti-cancer effects in HepG2 cells. PMID: 28864870 Ref: miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma. PMID: 28867541 Ref: Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo. PMID: 28874716 Ref: Antitumor activity of 2[(2E)3,7dimethyl2,6octadienyl]6methyl2,5cyclohexadiene1,4dione isolated from the aerial part of Atractylodes macrocephala in hepatocellular carcinoma. PMID: 28901513 Ref: Synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 and oxaliplatin via p53-independent pathway in vitro and in vivo. PMID: 28902369 Ref: Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells. PMID: 28903404 Ref: ANGPTL1 Interacts with Integrin alpha1beta1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. PMID: 28904065 Ref: Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. PMID: 28912543 Ref: Long non-coding RNA Igf2as controls hepatocellular carcinoma progression through the ERK/MAPK signaling pathway. PMID: 28928822 Ref: Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior. PMID: 28959024 Ref: BMP4 promotes oxaliplatin resistance by an induction of epithelial-mesenchymal transition via MEK1/ERK/ELK1 signaling in hepatocellular carcinoma. PMID: 28987388 Ref: N-terminal gelsolin fragment potentiates TRAIL mediated death in resistant hepatoma cells. PMID: 28993697 Ref: Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma. PMID: 29030911 Ref: Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas. PMID: 29038587 Ref: Regulation of ERK and AKT pathways by hepatitis B virus X protein via the Notch1 pathway in hepatocellular carcinoma. PMID: 29048612 Ref: Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. PMID: 29066484 Ref: Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer. PMID: 29068700 Ref: Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma. PMID: 29075359 Ref: Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1. PMID: 29085209 Ref: Overexpression of SIRT6 attenuates the tumorigenicity of hepatocellular carcinoma cells. PMID: 29100306 Ref: Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish. PMID: 29100373 Ref: Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells. PMID: 29100435 Ref: Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10. PMID: 29113314 Ref: Human primary liver cancer-derived organoid cultures for disease modeling and drug screening. PMID: 29131160 Ref: AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-kappaB signaling pathways. PMID: 29137357 Ref: microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma. PMID: 29152116 Ref: Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma. PMID: 29156696 Ref: Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice. PMID: 29263422 Ref: The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma. PMID: 29296518 Ref: Genetically engineered bone marrow-derived mesenchymal stem cells co-expressing IFN-gamma and IL-10 inhibit hepatocellular carcinoma by modulating MAPK pathway. PMID: 29332347 Ref: Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells. PMID: 30023637 |
Ref: Attenuation of liver cancer development by oral glycerol supplementation in the rat. PMID: 28255652 Ref: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma. PMID: 28954551 Ref: OAMDP, a novel podophyllotoxin derivative, induces apoptosis, cell cycle arrest and autophagy in hepatoma HepG2 cells. PMID: 29052919 Ref: Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. PMID: 29115423 Ref: Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells. PMID: 29128513 Ref: Synergistic anticancer activity of 20(S)-Ginsenoside Rg3 and Sorafenib in hepatocellular carcinoma by modulating PTEN/Akt signaling pathway. PMID: 29156516 Ref: Cantharidic acid induces apoptosis through the p38 MAPK signaling pathway in human hepatocellular carcinoma. PMID: 29159945 Ref: Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma. PMID: 29175326 Ref: Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling. PMID: 29188798 Ref: Localized delivery of chemokine for in vitro manipulation of hepatocellular carcinoma cell behaviors during the epithelial-mesenchymal transition. PMID: 29199892 Ref: Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake. PMID: 29205334 Ref: Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib. PMID: 29251327 Ref: Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. PMID: 29326072 Ref: Demethylation-Induced Overexpression of Shc3 Drives c-Raf-Independent Activation of MEK/ERK in HCC. PMID: 29330146 Ref: MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence. PMID: 29357919 Ref: Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway. PMID: 29377347 Ref: Epigenetic basis of hepatocellular carcinoma: A network-based integrative meta-analysis. PMID: 29399289 Ref: GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. PMID: 29408502 Ref: The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, beta-Catenin-Mutated Mouse Model. PMID: 29409568 Ref: Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinoma. PMID: 29416928 Ref: Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option. PMID: 29423069 Ref: Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals. PMID: 29436591 Ref: PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma. PMID: 29441724 Ref: Pin1 impairs microRNA biogenesis by mediating conformation change of XPO5 in hepatocellular carcinoma. PMID: 29445125 Ref: Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development. PMID: 29463989 Ref: The ER-alpha36/EGFR signaling loop promotes growth of hepatocellular carcinoma cells. PMID: 29481815 Ref: Early LC3 lipidation induced by d-limonene does not rely on mTOR inhibition, ERK activation and ROS production and it is associated with reduced clonogenic capacity of SH-SY5Y neuroblastoma cells. PMID: 29496180 Ref: Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic beta-Catenin, PIK3CA and MET. PMID: 29505847 Ref: Downregulation of castor zinc finger 1 predicts poor prognosis and facilitates hepatocellular carcinoma progression via MAPK/ERK signaling. PMID: 29506567 Ref: Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways. PMID: 29510199 Ref: Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. PMID: 29563756 Ref: Inhibition of anaplastic lymphoma kinase promotes apoptosis and suppresses proliferation in human hepatocellular carcinoma. PMID: 29570100 Ref: MAP Kinase-Interacting Kinase 1 Promotes Proliferation and Invasion of Hepatocellular Carcinoma and Is an Unfavorable Prognostic Biomarker. PMID: 29576605 Ref: Amentoflavone Enhances the Therapeutic Efficacy of Sorafenib by Inhibiting Anti-apoptotic Potential and Potentiating Apoptosis in Hepatocellular Carcinoma In Vivo. PMID: 29599330 Ref: Pharmacological inhibition of TRPV4 channel suppresses malignant biological behavior of hepatocellular carcinoma via modulation of ERK signaling pathway. PMID: 29635900 Ref: Hispidulin inhibits hepatocellular carcinoma growth and metastasis through AMPK and ERK signaling mediated activation of PPARgamma. PMID: 29656183 Ref: The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth. PMID: 29706623 Ref: The Role of Exportin-5 in MicroRNA Biogenesis and Cancer. PMID: 29723684 Ref: HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway. PMID: 29725020 Ref: [Glycyrrhetinic acid selectively inhibits proliferation of hepatocellular carcinoma cells in vitro]. PMID: 29735451 Ref: MiR-3662 suppresses hepatocellular carcinoma growth through inhibition of HIF-1alpha-mediated Warburg effect. PMID: 29748591 Ref: A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis. PMID: 29749642 Ref: Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells. PMID: 29763915 Ref: MTBP inhibits the Erk1/2-Elk-1 signaling in hepatocellular carcinoma. PMID: 29765550 Ref: Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT. PMID: 29782854 Ref: Cinobufacini inhibits epithelial-mesenchymal transition of human hepatocellular carcinoma cells through c-Met/ERK signaling pathway. PMID: 29794405 Ref: Effect of long non-coding RNA H19 on oxidative stress and chemotherapy resistance of CD133+ cancer stem cells via the MAPK/ERK signaling pathway in hepatocellular carcinoma. PMID: 29800569 Ref: Pyran-2-one derivatives from Croton crassifolius as potent apoptosis inducers in HepG2 cells via p53-mediated Ras/Raf/ERK pathway. PMID: 29852310 Ref: Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines. PMID: 29858683 Ref: Methionine Sulfoxide Reductase B1 Regulates Hepatocellular Carcinoma Cell Proliferation and Invasion via the Mitogen-Activated Protein Kinase Pathway and Epithelial-Mesenchymal Transition. PMID: 29861830 Ref: Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1alpha/VEGFA signalling in hepatocellular carcinoma. PMID: 29866133 Ref: Tachypleus tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress In Vivo Hepatocellular Carcinoma Growth. PMID: 29880736 Ref: Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation. PMID: 29917219 Ref: Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway. PMID: 29954442 Ref: Coronarin D induces apoptotic cell death through the JNK pathway in human hepatocellular carcinoma. PMID: 29968959 Ref: Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft. PMID: 29978739 Ref: HCV-induced EGFR-ERK signaling promotes a pro-inflammatory and pro-angiogenic signature contributing to liver cancer pathogenesis. PMID: 30012461 Ref: Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells. PMID: 30026540 Ref: A CCDC50 splice variant is modulated by SRSF3 and promotes hepatocellular carcinoma via the Ras signaling pathway. PMID: 30028541 Ref: Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer. PMID: 30030148 Ref: Deregulation of methionine metabolism as determinant of progression and prognosis of hepatocellular carcinoma. PMID: 30050996 Ref: Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK. PMID: 30106087 Ref: MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway. PMID: 30108016 Ref: LncRNA DBH-AS1 facilitates the tumorigenesis of hepatocellular carcinoma by targeting miR-138 via FAK/Src/ERK pathway. PMID: 30142544 Ref: Anlotinib induces hepatocellular carcinoma apoptosis and inhibits proliferation via Erk and Akt pathway. PMID: 30146257 Ref: Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade. PMID: 30182439 Ref: Alpha-mangostin, an active compound in Garcinia mangostana, abrogates anoikis-resistance in human hepatocellular carcinoma cells. PMID: 30195041 Ref: The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis. PMID: 30206312 Ref: delta-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8(+) T cell activation. PMID: 30221043 Ref: Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats. PMID: 30224923 Ref: Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatment. PMID: 30227844 Ref: HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways. PMID: 30231922 Ref: Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma. PMID: 30279729 Ref: mTOR and ERK regulate VKORC1 expression in both hepatoma cells and hepatocytes which influence blood coagulation. PMID: 30306378 Ref: LINC00707 promotes hepatocellular carcinoma progression through activating ERK/JNK/AKT pathway signaling pathway. PMID: 30317590 Ref: [Mechanism of angiotensin II (Ang II) on the proliferation of human hepatoma cell line HepG2 cells]. PMID: 30317792 Ref: PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation. PMID: 30332648 Ref: SPARC acts as a mediator of TGF-beta1 in promoting epithelial-to-mesenchymal transition in A549 and H1299 lung cancer cells. PMID: 30346081 Ref: lncRNA DRHC inhibits proliferation and invasion in hepatocellular carcinoma via c-Myb-regulated MEK/ERK signaling. PMID: 30362626 Ref: PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway. PMID: 30365128 Ref: Evodiamine Induces Apoptosis in SMMC-7721 and HepG2 Cells by Suppressing NOD1 Signal Pathway. PMID: 30384473 |