Primary Site >> Biliary tract Cancer

Gene >> EPHA2

  • 2011
  • 2013
  • 2014
Ref: Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma.
PMID: 21253578
 Ref: Activation of mammalian target of rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor-mediated Eph receptor 2 (EphA2) is required for cholangiocarcinoma growth and metastasis.
PMID: 23315987
Ref: Contribution of the PI3K/MMPs/Ln-5gamma2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas.
PMID: 23588386
 Ref: Inhibition of tumor vasculogenic mimicry and prolongation of host survival in highly aggressive gallbladder cancers by norcantharidin via blocking the ephrin type a receptor 2/focal adhesion kinase/paxillin signaling pathway.
PMID: 24811250