Primary Site >> Colorectal Cancer
Gene >> EP300
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Ref: p300 gene alterations in colorectal and gastric carcinomas. PMID: 8622873 |
Ref: Conjunction dysfunction: CBP/p300 in human disease. PMID: 9613201 Ref: Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y. PMID: 9632821 |
Ref: Mutations truncating the EP300 acetylase in human cancers. PMID: 10700188 Ref: Regulation of beta -catenin transformation by the p300 transcriptional coactivator. PMID: 11050151 |
Ref: The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. PMID: 11532957 Ref: Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. PMID: 11559818 |
Ref: Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway. PMID: 11896466 Ref: Transcriptional deregulation of the keratin 18 gene in human colon carcinoma cells results from an altered acetylation mechanism. PMID: 12140315 Ref: Mutation analysis of EP300 in colon, breast and ovarian carcinomas. PMID: 12385008 Ref: Role of coactivators and corepressors in the induction of the RARbeta gene in human colon cancer cells. PMID: 12392082 |
Ref: Nemo-like kinase suppresses a wide range of transcription factors, including nuclear factor-kappaB. PMID: 14720327 Ref: A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability. PMID: 14732695 Ref: Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. PMID: 14737099 Ref: Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. PMID: 14976201 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 |
Ref: Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression. PMID: 15782138 Ref: Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? PMID: 16126938 Ref: Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity. PMID: 16227401 Ref: Expression analysis of a subset of coregulators and three nuclear receptors in human colorectal carcinoma. PMID: 16309230 |
Ref: Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. PMID: 16525728 Ref: Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition. PMID: 16622451 Ref: The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. PMID: 16804902 Ref: Metabolic consequences of p300 gene deletion in human colon cancer cells. PMID: 16885360 Ref: The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal carcinomas. PMID: 17029218 Ref: Regulating p73 isoforms in human tumours. PMID: 17044134 |
Ref: The functional significance of nuclear receptor acetylation. PMID: 17291555 Ref: CBP/p300 are bimodal regulators of Wnt signaling. PMID: 17410209 Ref: Expression of HDAC1 and CBP/p300 in human colorectal carcinomas. PMID: 17720775 Ref: Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. PMID: 17908689 Ref: A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. PMID: 18054336 |
Ref: PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. PMID: 18797151 Ref: Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. PMID: 18799463 Ref: Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. PMID: 19000900 |
Ref: The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. PMID: 19297328 Ref: Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. PMID: 19366806 |
Ref: KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. PMID: 19901072 Ref: Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. PMID: 20442290 Ref: Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. PMID: 20924967 Ref: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis. PMID: 21103407 Ref: Nonsense mediated decay resistant mutations are a source of expressed mutant proteins in colon cancer cell lines with microsatellite instability. PMID: 21209843 |
Ref: CITED2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid. PMID: 21165656 Ref: PTTG1 attenuates drug-induced cellular senescence. PMID: 21858218 |
Ref: Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. PMID: 22409325 Ref: Colon cancer at the molecular level--usefulness of epithelial-mesenchymal transition analysis. PMID: 23700897 |
Ref: Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways. PMID: 23330808 Ref: ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. PMID: 23340304 Ref: The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis. PMID: 23618903 Ref: Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. PMID: 23737956 Ref: Frameshift mutations of tumor suppressor gene EP300 in gastric and colorectal cancers with high microsatellite instability. PMID: 23759652 Ref: p300 Influences Butyrate-Mediated WNT Hyperactivation In Colorectal Cancer Cells. PMID: 23901349 Ref: Prognostic impact of p300 expression in patients with colorectal cancer. PMID: 24142575 |
Ref: P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth. PMID: 24468085 Ref: Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer. PMID: 24532795 Ref: Modulation of Wnt Activity and Cell Physiology by Butyrate in LT97 Microadenoma Cells. PMID: 24563675 Ref: PPARdelta deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. PMID: 24610641 Ref: Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. PMID: 24755471 Ref: Plumbagin downregulates Wnt signaling independent of p53 in human colorectal cancer cells. PMID: 24828199 Ref: Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies. PMID: 24835815 Ref: Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators. PMID: 24948597 Ref: ArhGAP30 promotes p53 acetylation and function in colorectal cancer. PMID: 25156493 Ref: Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620. PMID: 25205133 Ref: Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress. PMID: 25245946 Ref: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells. PMID: 25321483 |
Ref: SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. PMID: 25277775 Ref: The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. PMID: 25728681 Ref: IFNgamma Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer. PMID: 25735954 Ref: TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells. PMID: 26140605 Ref: Acetylation-dependent function of human single-stranded DNA binding protein 1. PMID: 26170237 Ref: Altering cancer transcriptomes using epigenomic inhibitors. PMID: 26191083 Ref: CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer. PMID: 26217075 Ref: ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression. PMID: 26387539 |
Ref: DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. PMID: 26494468 Ref: Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers. PMID: 26764183 Ref: KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. PMID: 26839262 Ref: Bioinformatic exploration of MTA1-regulated gene networks in colon cancer. PMID: 27052252 Ref: Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1alpha/p300 Interaction. PMID: 27140429 Ref: Determination of the Role of CBP- and p300-Mediated Wnt Signaling on Colonic Cells. PMID: 27177606 Ref: Wnt/beta-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. PMID: 27285761 Ref: TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. PMID: 27818144 |
Ref: CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45. PMID: 28068431 Ref: Whole-exome sequencing identified mutational profiles of high-grade colon adenomas. PMID: 28179590 Ref: Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. PMID: 28341962 Ref: 5-Fluorouracil targets histone acetyltransferases p300/CBP in the treatment of colorectal cancer. PMID: 28465257 Ref: Expression of the EP300, TP53 and BAX genes in colorectal cancer: Correlations with clinicopathological parameters and survival. PMID: 28586030 Ref: ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC. PMID: 28638460 Ref: Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. PMID: 28655792 Ref: Blocking endothelin-1-receptor/beta-catenin circuit sensitizes to chemotherapy in colorectal cancer. PMID: 28708138 Ref: Expression and role of nuclear receptor coregulators in colorectal cancer. PMID: 28740336 Ref: Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. PMID: 28756022 Ref: Inhibition of Wnt/beta-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer. PMID: 28916833 Ref: XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. PMID: 29049411 Ref: Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300. PMID: 29069825 Ref: p300 Knockout Promotes Butyrate Resistance. PMID: 29151923 Ref: Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids. PMID: 29354056 |
Ref: Benign and malignant tumors in Rubinstein-Taybi syndrome. PMID: 29359884 Ref: P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. PMID: 29454793 Ref: CREPT facilitates colorectal cancer growth through inducing Wnt/beta-catenin pathway by enhancing p300-mediated beta-catenin acetylation. PMID: 29563608 Ref: KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2. PMID: 29632619 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. PMID: 29954944 Ref: Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. PMID: 30214631 |