Primary Site >> Colorectal Cancer

Gene >> EIF4EBP1

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Ref: Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture.
PMID: 12000755
 Ref: The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells.
PMID: 15846119
 Ref: Global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis.
PMID: 16531451
 Ref: Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
PMID: 17440067
 Ref: Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.
PMID: 18332469
 Ref: mTOR signaling pathway is a target for the treatment of colorectal cancer.
PMID: 19517193
 Ref: Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.
PMID: 20971826
 Ref: mTOR signaling is involved in indomethacin and nimesulide suppression of colorectal cancer cell growth via a COX-2 independent pathway.
PMID: 20803081
 Ref: The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.
PMID: 22154651
Ref: mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors.
PMID: 22262166
Ref: The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.
PMID: 22415236
 Ref: Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells.
PMID: 23188704
Ref: Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse.
PMID: 23589074
Ref: Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression.
PMID: 23827854
Ref: The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.
PMID: 24339963
 Ref: Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.
PMID: 24602180
Ref: Depletion of white adipose tissue in cancer cachexia syndrome is associated with inflammatory signaling and disrupted circadian regulation.
PMID: 24667661
Ref: New insights into 4E-BP1-regulated translation in cancer progression and metastasis.
PMID: 26005705
 Ref: mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
PMID: 25383520
 Ref: PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer.
PMID: 26434594
Ref: Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.
PMID: 27729552
 Ref: Oncogenic beta-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.
PMID: 28442534
Ref: Phosphorylated 4E-BP1 is associated with tumor progression and adverse prognosis in colorectal cancer.
PMID: 28592131
Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer.
PMID: 29110225
 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition.
PMID: 30201826