Primary Site >> Colorectal Cancer
Gene >> EIF2AK3
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Ref: Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. PMID: 15483017 |
Ref: Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells. PMID: 16524888 Ref: Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer. PMID: 16763611 Ref: Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach. PMID: 16867865 |
Ref: Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. PMID: 17283163 Ref: A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. PMID: 17574271 |
Ref: Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. PMID: 18451152 Ref: Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients. PMID: 18575712 |
Ref: Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors. PMID: 19492075 Ref: Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. PMID: 19754954 |
Ref: Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine. PMID: 19737563 Ref: The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). PMID: 20130018 Ref: Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity. PMID: 20232300 Ref: Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched primary tumor and lymph node metastases. PMID: 20572035 Ref: Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles. PMID: 20664940 Ref: Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. PMID: 20716165 |
Ref: Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17. PMID: 21148749 Ref: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer. PMID: 21233674 Ref: Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa. PMID: 21625488 Ref: Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. PMID: 21664646 Ref: 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells. PMID: 21936401 Ref: Depletion of tissue factor suppresses hepatic metastasis and tumor growth in colorectal cancer via the downregulation of MMPs and the induction of autophagy and apoptosis. PMID: 22052255 |
Ref: Expression of EGFR, HER2, phosphorylated ERK and phosphorylated MEK in colonic neoplasms of familial adenomatous polyposis patients. PMID: 21989899 Ref: The non-steroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. PMID: 22268531 Ref: CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. PMID: 22319199 Ref: ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics. PMID: 22376079 Ref: Differential response to EGFR- and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases. PMID: 22581265 Ref: DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. PMID: 22898250 |
Ref: Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1/cip1) expression in human colon carcinoma HT-29 cells. PMID: 22025467 Ref: Circulating vascular endothelial growth factor receptor 2/pAkt-positive cells as a functional pharmacodynamic marker in metastatic colorectal cancers treated with antiangiogenic agent. PMID: 22539090 Ref: 20-O-(beta-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells. PMID: 23381572 Ref: Effects of pemetrexed, gefitinib, and their combination on human colorectal cancer cells. PMID: 23959460 Ref: High level of p37delta-mRNA relative to p110delta-mRNA in neuroblastoma tumors correlates with poor patient survival. PMID: 24026661 Ref: The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. PMID: 24104354 Ref: Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. PMID: 24113185 |
Ref: Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells. PMID: 24378333 Ref: Role of ATF3 in synergistic cancer cell killing by a combination of HDAC inhibitors and agonistic anti-DR5 antibody through ER stress in human colon cancer cells. PMID: 24530917 Ref: Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-re PMID: 24939851 Ref: DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. PMID: 24953781 Ref: Therapeutic silencing of KRAS using systemically delivered siRNAs. PMID: 25281617 |
Ref: A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours. PMID: 25268371 Ref: Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib. PMID: 25514114 Ref: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy. PMID: 25896895 Ref: Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time-dependent manner in HCT116 colon cancer cells. PMID: 25901510 Ref: Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics. PMID: 26513173 Ref: Mulberry fruit prevents LPS-induced NF-kappaB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice. PMID: 26615818 Ref: Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers. PMID: 26678268 |
Ref: Antitumor Activity of HM781-36B, alone or in Combination with Chemotherapeutic Agents, in Colorectal Cancer Cells. PMID: 25761479 Ref: TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways. PMID: 26212606 Ref: FAM172A is a tumor suppressor in colorectal carcinoma. PMID: 26637224 Ref: The miR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells. PMID: 26913599 Ref: Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines. PMID: 26988975 Ref: Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations. PMID: 27036313 Ref: Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells. PMID: 27078027 Ref: Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment. PMID: 27166181 Ref: Non-thermal gas plasma-induced endoplasmic reticulum stress mediates apoptosis in human colon cancer cells. PMID: 27573888 Ref: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. PMID: 27662663 Ref: Combination effects of sorafenib with PI3K inhibitors under hypoxia in colorectal cancer. PMID: 27995152 |
Ref: Preclinical study of cinobufagin as a promising anti-colorectal cancer agent. PMID: 27894091 Ref: 3',5-dihydroxy-3,4',7-trimethoxyflavone-induces ER-stress-associated HCT-116 programmed cell death via redox signaling. PMID: 28103509 Ref: Salubrinal protects against Clostridium difficile toxin B-induced CT26 cell death. PMID: 28119311 Ref: TEOA, a triterpenoid from Actinidia eriantha, induces autophagy in SW620 cells via endoplasmic reticulum stress and ROS-dependent mitophagy. PMID: 28211011 Ref: Smad7 knockdown activates protein kinase RNA-associated eIF2alpha pathway leading to colon cancer cell death. PMID: 28300830 Ref: Curcumin derivative WZ35 efficiently suppresses colon cancer progression through inducing ROS production and ER stress-dependent apoptosis. PMID: 28337376 Ref: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. PMID: 28368414 Ref: Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78. PMID: 28551635 Ref: Knockout of MARCH2 inhibits the growth of HCT116 colon cancer cells by inducing endoplasmic reticulum stress. PMID: 28749466 Ref: Metformin Synergistically Potentiates the Antitumor Effects of Imatinib in Colorectal Cancer Cells. PMID: 28785735 Ref: PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). PMID: 28796255 Ref: Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. PMID: 29245915 |
Ref: Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response. PMID: 29024602 Ref: GOLPH3 expression promotes the resistance of HT29 cells to 5fluorouracil by activating multiple signaling pathways. PMID: 29115442 Ref: Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway. PMID: 29393371 Ref: Quantitative self-assembly prediction yields targeted nanomedicines. PMID: 29403054 Ref: Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer. PMID: 29879413 Ref: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDAMB231 cells. PMID: 29901199 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways. PMID: 29925224 Ref: Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations. PMID: 30118499 Ref: Astragaloside attenuates the progression of prostate cancer cells through endoplasmic reticulum stress pathways. PMID: 30128005 Ref: An update on dietary consideration in inflammatory bowel disease: anthocyanins and more. PMID: 30136591 Ref: Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells. PMID: 30199885 |