Primary Site >> Colorectal Cancer
Gene >> EIF2AK2
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Ref: Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. PMID: 9891046 |
Ref: Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR. PMID: 12483527 |
Ref: Expression of double-stranded RNA-activated protein kinase (PKR) and its prognostic significance in lymph node negative rectal cancer. PMID: 16148023 |
Ref: JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. PMID: 18535619 Ref: Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide. PMID: 18728285 |
Ref: PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. PMID: 19416861 Ref: Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect. PMID: 19440231 |
Ref: The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). PMID: 20130018 |
Ref: The non-steroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. PMID: 22268531 |
Ref: Bozepinib, a novel small antitumor agent, induces PKR-mediated apoptosis and synergizes with IFNalpha triggering apoptosis, autophagy and senescence. PMID: 24194639 |
Ref: Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2alpha kinase PKR. PMID: 25856684 Ref: The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways. PMID: 26061044 |
Ref: Smad7 knockdown activates protein kinase RNA-associated eIF2alpha pathway leading to colon cancer cell death. PMID: 28300830 Ref: Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue. PMID: 28596815 Ref: Blockade of the LRP16-PKR-NF-kappaB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy. PMID: 28820388 |
Ref: Kisspeptin Inhibits Colorectal Cancer Cell Invasiveness by Activating PKR and PP2A. PMID: 30275201 |