Primary Site >> Liver Cancer
Gene >> EHMT2
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Ref: Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. PMID: 17584191 |
Ref: Long-term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16(INK4a) and down-regulates its expression in the liver of mice. PMID: 22733434 Ref: A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. PMID: 23760081 |
Ref: Histone-modifying genes as biomarkers in hepatocellular carcinoma. PMID: 24966962 |
Ref: The Histone Methyltransferase Inhibitor BIX01294 Inhibits HIF-1alpha Stability and Angiogenesis. PMID: 26013382 |
Ref: Host genetic variants influencing the clinical course of hepatitis B virus infection. PMID: 26255971 Ref: Association of Histone Methyltransferase G9a and Overall Survival After Liver Resection of Patients With Hepatocellular Carcinoma With a Median Observation of 40 Months. PMID: 26765460 Ref: Arsenic silences hepatic PDK4 expression through activation of histone H3K9 methylatransferase G9a. PMID: 27217333 |
Ref: Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma. PMID: 28423509 Ref: Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3. PMID: 28532996 Ref: Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors. PMID: 28968981 Ref: Identification of additional EHMT2 variant associated with the risk of chronic hepatitis B by GWAS follow-up study. PMID: 29238036 |
Ref: Basil polysaccharide attenuates hepatocellular carcinoma metastasis in rat by suppressing H3K9me2 histone methylation under hepatic artery ligation-induced hypoxia. PMID: 29042275 Ref: Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search. PMID: 29498708 Ref: Increased expression of G9A contributes to carcinogenesis and indicates poor prognosis in hepatocellular carcinoma. PMID: 29928350 Ref: Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma. PMID: 30014490 |