Primary Site >> Colorectal Cancer
Gene >> EHMT2
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Ref: Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. PMID: 18332107 |
Ref: Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. PMID: 19843671 |
Ref: BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production. PMID: 24322755 |
Ref: Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation. PMID: 25595900 Ref: H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance. PMID: 26136424 |
Ref: H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. PMID: 25961932 Ref: Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells. PMID: 27259240 Ref: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/beta-catenin pathway. PMID: 27525719 Ref: Retraction: G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/beta-catenin pathway. PMID: 28008183 |
Ref: G9a governs colon cancer stem cell phenotype and chemoradioresistance through PP2A-RPA axis-mediated DNA damage response. PMID: 28351524 |
Ref: G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1. PMID: 29774081 Ref: Clinicopathological significance of G9A expression in colorectal carcinoma. PMID: 29805595 Ref: Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme. PMID: 30376874 |