Primary Site >> Colorectal Cancer
Gene >> EGLN1
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Ref: Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. PMID: 19844231 |
Ref: Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. PMID: 19786027 |
Ref: LDH-A influences hypoxia-inducible factor 1alpha (HIF1 alpha) and is critical for growth of HT29 colon carcinoma cells in vivo. PMID: 21660559 |
Ref: Low expression of prolyl hydroxylase 2 is associated with tumor grade and poor prognosis in patients with colorectal cancer. PMID: 22802519 Ref: Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. PMID: 22804960 Ref: Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. PMID: 22943412 Ref: Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1alpha stabilization in colon carcinoma cells. PMID: 22971010 |
Ref: Investigation of possible endogenous hypoxia markers in colorectal cancer. PMID: 22852555 Ref: Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer. PMID: 24195777 |
Ref: N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant. PMID: 24361888 |
Ref: HIF-prolyl hydroxylase is a potential molecular target for esculetin-mediated anti-colitic effects. PMID: 25797536 Ref: PHD1 regulates p53-mediated colorectal cancer chemoresistance. PMID: 26290450 |
Ref: The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1alpha Levels and Colorectal Cancer Cell Survival under Hypoxia. PMID: 28199842 Ref: Increased hypoxia-inducible factor-1alpha in striated muscle of tumor-bearing mice. PMID: 28341633 |
Ref: Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice. PMID: 29688249 Ref: A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53. PMID: 30339780 |