Primary Site >> Liver Cancer
Gene >> EGFR
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: [EGFR expression and EGF stimulation of proliferation in human liver carcinoma cells]. PMID: 2560604 |
Ref: c-erbB-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma. PMID: 1380026 |
Ref: Expression of transforming growth factor alpha in human hepatocellular carcinoma. PMID: 8393123 |
Ref: Serum levels of c-erbB-2 protein in digestive diseases. PMID: 7528080 Ref: [Clinical study of serum ErbB-2 protein using sandwich radioimmunometric assay (ErbB-2 IRMA 'Eiken')]. PMID: 7913312 |
Ref: TGF alpha differentially expressed in liver foci induced by diethylnitrosamine initiation and peroxisome proliferator promotion. PMID: 7530605 Ref: Nodules of less-differentiated tumor within or adjacent to hepatocellular carcinoma: relative expression of transforming growth factor-alpha and its receptor in the different areas of tumor. PMID: 7557946 Ref: [Expression of c-erbB-2 protein and EGF receptor in hepatitis B, cirrhosis and hepatocellular carcinoma]. PMID: 7788735 Ref: [An EGFR antisense oligodeoxynucleotides and its phosphorothioate analogue inhibit the growth of human hepatocarcinoma BEL-7404 cells]. PMID: 8571707 |
Ref: Association of inhibition of cell growth by O-phospho-L-tyrosine with decreased tyrosine phosphorylation. PMID: 8603380 Ref: The relationship between mast cell infiltration and the expression of PCNA and EGFr in experimental hepatocellular carcinoma of liver and squamous cell carcinoma of stomach in rats. PMID: 8758735 Ref: Detection of transforming growth factor-alpha protein and messenger RNA in hepatobiliary diseases by immunohistochemical and in situ hybridization techniques. PMID: 8760011 |
Ref: Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes. PMID: 9029167 Ref: Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate. PMID: 9108453 Ref: Quantitative relationship between transforming growth factor-alpha and hepatic focal phenotype and progression in female mouse liver. PMID: 9210259 Ref: Expression of transforming growth factor alpha and epidermal growth factor receptor in human hepatocellular carcinoma. PMID: 9298487 Ref: Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met,TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas. PMID: 9815784 Ref: [Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection]. PMID: 10920888 |
Ref: Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: relationship to cell proliferation. PMID: 10024677 Ref: Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma. PMID: 10459631 |
Ref: Malignant transformation and EGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma. PMID: 10699924 Ref: EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture. PMID: 10828207 |
Ref: Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma. PMID: 11355950 Ref: Proteome alterations in human hepatoma cells transfected with antisense epidermal growth factor receptor sequence. PMID: 11565794 |
Ref: K vitamins, PTP antagonism, and cell growth arrest. PMID: 12384979 |
Ref: Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer. PMID: 12560427 Ref: A novel HBV antisense RNA gene delivery system targeting hepatocellular carcinoma. PMID: 12632498 Ref: Investigation of ErbB1 and ErbB2 expression for therapeutic targeting in primary liver tumours. PMID: 12846405 Ref: Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-Myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice. PMID: 12878043 Ref: [Identification and characterization of LAPTM4B encoded by a human hepatocellular carcinoma-associated novel gene]. PMID: 12947545 |
Ref: Laminin-5 offsets the efficacy of gefitinib ('Iressa') in hepatocellular carcinoma cells. PMID: 15545972 |
Ref: Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics. PMID: 16023762 Ref: Establishment and characterization of three novel human gastric cancer cell lines with differentiated intestinal phenotype derived from liver metastasis. PMID: 16086234 |
Ref: ZD6474 inhibits proliferation and invasion of human hepatocellular carcinoma cells. PMID: 16332356 Ref: Cyclooxygenase-2 in hepatocellular carcinoma. PMID: 16337744 Ref: Dysregulation of growth factor signaling in human hepatocellular carcinoma. PMID: 16799620 Ref: Immunohistochemical expression of CD95 (Fas), c-myc and epidermal growth factor receptor in hepatitis C virus infection, cirrhotic liver disease and hepatocellular carcinoma. PMID: 16856963 Ref: Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. PMID: 16937526 Ref: Expression of betacellulin and epidermal growth factor receptor in hepatocellular carcinoma: implications for angiogenesis. PMID: 16949929 Ref: A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma. PMID: 17150109 |
Ref: Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats. PMID: 17031671 Ref: COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival. PMID: 17146741 Ref: Cimetidine inhibits epidermal growth factor-induced cell signaling. PMID: 17295779 Ref: New molecular targets for hepatocellular carcinoma: the ErbB1 signaling system. PMID: 17311611 Ref: Anti-tumor effects of immunotherapeutic peptide on the treatment of hepatocellular carcinoma with HBc carrier. PMID: 17549380 Ref: Expression of Rab5a in hepatocellular carcinoma: Possible involvement in epidermal growth factor signaling. PMID: 17581187 Ref: [Cell biology and genetics in liver cancer]. PMID: 17662221 Ref: Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. PMID: 17708250 Ref: Tyrosine kinase inhibitors: a potential approach to the treatment of hepatocellular carcinoma. PMID: 18045182 Ref: Angiogenesis soluble factors as hepatocellular carcinoma noninvasive markers for monitoring hepatitis C virus cirrhotic patients awaiting liver transplantation. PMID: 18049111 Ref: Liver stem cells and molecular signaling pathways in hepatocellular carcinoma. PMID: 19360142 |
Ref: siRNA mediated the type 1 insulin-like growth factor receptor and epidermal growth factor receptor silencing induces chemosensitization of liver cancer cells. PMID: 17901981 Ref: Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. PMID: 17998146 Ref: [News in digestive oncology]. PMID: 18230577 Ref: EGFR and VEGFR as potential target for biological therapies in HCC cells. PMID: 18248788 Ref: Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter phase 2 study. PMID: 18412149 Ref: Lack of somatic ErbB2 tyrosine kinase domain mutations in hepatocellular carcinoma. PMID: 18462377 Ref: Clinical impact of serum transforming growth factor-alpha mRNA as a predictive biomarker for the prognosis of fulminant hepatitis. PMID: 19669307 |
Ref: A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. PMID: 19169683 Ref: Epidermal growth factor receptor vIII enhances tumorigenicity and resistance to 5-fluorouracil in human hepatocellular carcinoma. PMID: 19217205 Ref: A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. PMID: 19234449 Ref: Updates in Gastrointestinal Oncology - insights from the 2008 44th annual meeting of the American Society of Clinical Oncology. PMID: 19236713 Ref: Aromatase in nontumoral and malignant human liver tissues and cells. PMID: 19250204 Ref: [Targeted therapies and their indications in solid neoplasias]. PMID: 19299048 Ref: Identification of potential driver genes in human liver carcinoma by genomewide screening. PMID: 19366792 Ref: [Targeted therapies in hepatocellular carcinomas: recent results and future development]. PMID: 19467986 Ref: Transcriptional toxicity of the Yangtze River source water on mouse (Mus musculus) detected by cDNA microarray. PMID: 19499331 Ref: [Two cases of KRAS wild-type unresectable or recurrent colorectal cancer effectively treated by cetuximab after progression of prior chemotherapy]. PMID: 19542725 Ref: A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. PMID: 19737952 Ref: Antisense phosphorothioate oligodeoxynucleic acid for CD10 suppresses liver metastasis of colorectal cancer. PMID: 19816087 |
Ref: Preparation of EGFR monoclonal antibody conjugated nanoparticles and targeting to hepatocellular carcinoma. PMID: 19921404 Ref: The mitogenic effectors of isoproterenol in human hepatocellular carcinoma cells. PMID: 19956875 Ref: GH modulates hepatic epidermal growth factor signaling in the mouse. PMID: 20032199 Ref: Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents. PMID: 20056425 Ref: Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice. PMID: 20101389 Ref: Molecular genetics of hepatocellular neoplasia. PMID: 20182587 Ref: Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line. PMID: 20304535 Ref: Beyond sorafenib: novel targeted therapies for advanced hepatocellular carcinoma. PMID: 20367287 Ref: Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity. PMID: 20502062 Ref: Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation. PMID: 20596631 Ref: Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy. PMID: 20607690 Ref: Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor. PMID: 20618941 |
Ref: Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells. PMID: 21093979 Ref: Targeting EGFR in bilio-pancreatic and liver carcinoma. PMID: 21196353 Ref: Combinational RNAi gene therapy of hepatocellular carcinoma by targeting human EGFR and TERT. PMID: 21238587 Ref: The NADPH oxidase inhibitor VAS2870 impairs cell growth and enhances TGF-beta-induced apoptosis of liver tumor cells. PMID: 21276422 Ref: Molecular pathogenesis of hepatocellular carcinoma. PMID: 21303380 Ref: Oncosuppressor methylation: a possible key role in colon metastatic progression. PMID: 21506124 Ref: EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis. PMID: 21512140 Ref: Genetics of hepatobiliary carcinogenesis. PMID: 21538283 Ref: Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways. PMID: 21618577 Ref: Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. PMID: 21649584 Ref: Changing pathology with changing drugs: tumors of the gastrointestinal tract. PMID: 21677471 Ref: Renal function in patients undergoing transplantation for nonalcoholic steatohepatitis cirrhosis: time to reconsider immunosuppression regimens? PMID: 21761549 Ref: Molecular targeted therapy for hepatocellular carcinoma: bench to bedside. PMID: 21829017 Ref: The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. PMID: 21864510 Ref: Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro. PMID: 22088142 Ref: Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma. PMID: 22110214 Ref: [Three cases of patients in their eighties who received anti-EGFR antibody mono-therapy as first-line treatment for metastatic colorectal cancer]. PMID: 22202343 |
Ref: EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma. PMID: 21963149 Ref: Mechanistic study on liver tumor promoting effects of flutamide in rats. PMID: 22076107 Ref: Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer. PMID: 22080573 Ref: Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101. PMID: 22210086 Ref: Cross-talk between TGFbeta1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition. PMID: 22292774 Ref: Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. PMID: 22409860 Ref: [Association of genetic polymorphisms of key molecules in JAK/STAT signaling pathway with susceptibility of hepatocellular carcinoma]. PMID: 22575147 Ref: DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. PMID: 22593025 Ref: Hepatocellular carcinoma: important biomarkers and their significance in molecular diagnostics and therapy. PMID: 22680921 Ref: Sorafenib in non-small cell lung cancer. PMID: 22725255 Ref: Surface glycoproteomic analysis of hepatocellular carcinoma cells by affinity enrichment and mass spectrometric identification. PMID: 22752401 Ref: Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling. PMID: 22768190 Ref: The transcription factor c-Jun protects against liver damage following activated beta-Catenin signaling. PMID: 22792392 Ref: HGFK1 is associated with a better prognosis and reverses inhibition by gefitinib in NSCLC cases. PMID: 22799348 Ref: Tas13D inhibits growth of SMMC-7721 cell via suppression VEGF and EGF expression. PMID: 22901163 Ref: Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity. PMID: 22980218 Ref: Dual-specificity phosphatases are targets of the Wnt/beta-catenin pathway and candidate mediators of beta-catenin/Ras signaling interactions. PMID: 23089536 Ref: Multivariate analysis of molecular indicators for postoperative liver metastasis in colorectal cancer cases. PMID: 23098501 |
Ref: Molecular characteristics of fibrolamellar hepatocellular carcinoma. PMID: 22872444 Ref: Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. PMID: 22899566 Ref: The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation. PMID: 23220047 Ref: The role of pharmacoethnicity in the development of cytotoxic and molecular targeted drugs in oncology. PMID: 23225792 Ref: Clinical impact of hepatitis B and C virus envelope glycoproteins. PMID: 23429668 Ref: Prostaglandin E(2) receptor EP1-mediated phosphorylation of focal adhesion kinase enhances cell adhesion and migration in hepatocellular carcinoma cells. PMID: 23525457 Ref: Role and regulation of PDGFRalpha signaling in liver development and regeneration. PMID: 23529017 Ref: Cytohesin-2 as a novel prognostic marker for hepatocellular carcinoma. PMID: 23545718 Ref: Signal transduction disturbance related to hepatocarcinogenesis in mouse by prolonged exposure to Nanjing drinking water. PMID: 23591932 Ref: Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells. PMID: 23721490 Ref: Actionable gene expression-based patient stratification for molecular targeted therapy in hepatocellular carcinoma. PMID: 23785399 Ref: Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China. PMID: 23790025 Ref: Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer. PMID: 23792568 Ref: Triterpenoid pristimerin induced HepG2 cells apoptosis through ROS-mediated mitochondrial dysfunction. PMID: 23818365 Ref: Epidermal growth factor, its receptor and transforming growth factor-beta1 in the diagnosis of HCV-induced hepatocellular carcinoma. PMID: 23912699 Ref: MUC15 inhibits dimerization of EGFR and PI3K-AKT signaling and is associated with aggressive hepatocellular carcinomas in patients. PMID: 23933603 Ref: Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA. PMID: 24060417 Ref: MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells. PMID: 24083596 Ref: Novel compound PS-101 exhibits selective inhibition in non-small-cell lung cancer cell by blocking the EGFR-driven antiapoptotic pathway. PMID: 24161785 Ref: iSubgraph: integrative genomics for subgroup discovery in hepatocellular carcinoma using graph mining and mixture models. PMID: 24223834 Ref: Clinical trials in hepatocellular carcinoma: an update. PMID: 24400222 Ref: Targeted therapies in development for non-small cell lung cancer. PMID: 24574860 |
Ref: Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma. PMID: 23721168 Ref: The monoclonal antibody CH12 augments 5-fluorouracil-induced growth suppression of hepatocellular carcinoma xenografts expressing epidermal growth factor receptor variant III. PMID: 24007863 Ref: The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment. PMID: 24268047 Ref: The EGFR signalling system in the liver: from hepatoprotection to hepatocarcinogenesis. PMID: 24318021 Ref: Combination of cetuximab and rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma. PMID: 24325131 Ref: Decorin deficiency promotes hepatic carcinogenesis. PMID: 24361483 Ref: Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression. PMID: 24378923 Ref: Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. PMID: 24607627 Ref: Prostaglandin E(2) receptor EP2 mediates Snail expression in hepatocellular carcinoma cells. PMID: 24626807 Ref: Gold nanoparticles and radiofrequency in experimental models for hepatocellular carcinoma. PMID: 24650884 Ref: Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. PMID: 24677197 Ref: Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3beta pathways in vivo. PMID: 24691449 Ref: Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection. PMID: 24703510 Ref: PKM2 regulates hepatocellular carcinoma cell epithelial-mesenchymal transition and migration upon EGFR activation. PMID: 24716919 Ref: TGF-beta Mediated Crosstalk Between Malignant Hepatocyte and Tumor Microenvironment in Hepatocellular Carcinoma. PMID: 24741325 Ref: Prostaglandin E2 accelerates invasion by upregulating Snail in hepatocellular carcinoma cells. PMID: 24760275 Ref: Targeting EGFL7 expression through RNA interference suppresses renal cell carcinoma growth by inhibiting angiogenesis. PMID: 24815445 Ref: The prognostic value of the Na(+)/ H(+) exchanger regulatory factor 1 (NHERF1) protein in cancer. PMID: 24878819 Ref: Activated macrophages down-regulate expression of E-cadherin in hepatocellular carcinoma cells via NF-kappaB/Slug pathway. PMID: 24894673 Ref: Synergistic effect of MiR-146a mimic and cetuximab on hepatocellular carcinoma cells. PMID: 24895573 Ref: The role of targeted therapy for gastrointestinal tumors. PMID: 24957206 Ref: Celastrol enhanced the anticancer effect of lapatinib in human hepatocellular carcinoma cells in vitro. PMID: 24965400 Ref: Design, synthesis and molecular modeling of biquinoline-pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors. PMID: 25172421 Ref: Crosstalk between EGFR and p53 in hepatocellular carcinoma. PMID: 25338986 Ref: Evolution of hepatic steatosis to fibrosis and adenoma formation in liver-specific growth hormone receptor knockout mice. PMID: 25566190 |
Ref: Mannose-mediated inhibitory effects of PA-MSHA on invasion and metastasis of hepatocellular carcinoma via EGFR/Akt/IkappaBbeta/NF-kappaB pathway. PMID: 25066210 Ref: Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. PMID: 25179284 Ref: A phase I and pharmacokinetic study of ganetespib (STA-9090) in advanced hepatocellular carcinoma. PMID: 25248753 Ref: Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells. PMID: 25338626 Ref: gamma-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1alpha/VEGF pathways under hypoxic condition. PMID: 25537504 Ref: Epidermal growth factor receptor pathway polymorphisms and the prognosis of hepatocellular carcinoma. PMID: 25628948 Ref: Novel molecular targets for diagnosis and treatment of hepatocellular carcinoma. PMID: 25636956 Ref: Nexavar/Stivarga and viagra interact to kill tumor cells. PMID: 25704960 Ref: Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling. PMID: 25730904 Ref: Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis. PMID: 25744849 Ref: Enoyl-coenzyme A hydratase short chain 1 silencing attenuates the proliferation of hepatocellular carcinoma by inhibiting epidermal growth factor signaling in vitro and in vivo. PMID: 25760819 Ref: Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events. PMID: 25872475 Ref: Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction. PMID: 25872741 Ref: The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated alpha2M. PMID: 25958313 Ref: Systemic therapy of cholangiocarcinoma: From chemotherapy to targeted therapies. PMID: 25966433 Ref: Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma. PMID: 25973308 Ref: Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. PMID: 25980493 Ref: The EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma. PMID: 26000702 Ref: Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13. PMID: 26026309 Ref: Lower serum soluble-EGFR is a potential biomarker for metastasis of HCC demonstrated by N-glycoproteomic analysis. PMID: 26105696 Ref: Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice. PMID: 26122702 Ref: The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles. PMID: 26139123 Ref: Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PMID: 26147004 Ref: Morphological aspects of the hepatic response to neoadjuvant therapy. PMID: 26163186 Ref: BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a Potential Biomarker in Ovarian Cancer. PMID: 26222696 Ref: A significant response to sorafenib in a woman with advanced lung adenocarcinoma and a BRAF non-V600 mutation. PMID: 26237499 Ref: Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. PMID: 26259512 Ref: Anti-tumor effect of LTA combined with 5-FU on H22 tumor bearing mice. PMID: 26276288 Ref: Impact of epidermal growth factor receptor and transforming growth factor-alpha on hepatitis C virus-induced hepatocarcinogenesis. PMID: 26279457 Ref: Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. PMID: 26409325 Ref: Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis. PMID: 26492920 Ref: Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways. PMID: 26636335 Ref: [Alternative Splicing Detection as a Biomarker for Cancer Diagnosis: A Novel Progressive Mechanism of Acute Lymphoblastic Leukemia with Alternative Splicing as a Biomarker Candidate]. PMID: 26731899 Ref: Targeting Viral Entry for Treatment of Hepatitis B and C Virus Infections. PMID: 27617925 |
Ref: Amarogentin regulates self renewal pathways to restrict liver carcinogenesis in experimental mouse model. PMID: 26154024 Ref: The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma. PMID: 26271667 Ref: Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma. PMID: 26386721 Ref: Tea polyphenols epigallocatechin gallete and theaflavin restrict mouse liver carcinogenesis through modulation of self-renewal Wnt and hedgehog pathways. PMID: 26386739 Ref: MicroRNA-107: a novel promoter of tumor progression that targets the CPEB3/EGFR axis in human hepatocellular carcinoma. PMID: 26497556 Ref: Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options. PMID: 26661118 Ref: Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance. PMID: 26801674 Ref: Sex Difference of Egfr Expression and Molecular Pathway in the Liver: Impact on Drug Design and Cancer Treatments? PMID: 27076848 Ref: Genome-wide association study identified PLCE1- rs2797992 and EGFR- rs6950826 were associated with TP53 expression in the HBV-related hepatocellular carcinoma of Chinese patients in Guangxi. PMID: 27186304 Ref: Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. PMID: 27224921 Ref: EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway. PMID: 27244890 Ref: (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. PMID: 27287718 Ref: iRGD-Decorated Polymeric Nanoparticles for the Efficient Delivery of Vandetanib to Hepatocellular Carcinoma: Preparation and in Vitro and in Vivo Evaluation. PMID: 27381493 Ref: Actinidia chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression. PMID: 27475644 Ref: EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma. PMID: 27502069 Ref: Repression of Human Hepatocellular Carcinoma Growth by Regulating Met/EGFR/VEGFR-Akt/NF-kappaB Pathways with Theanine and Its Derivative, (R)-2-(6,8-Dibromo-2-oxo-2H-chromene-3-carboxamido)-5-(ethylamino)-5-oxopentanoic Ethyl Ester (DTBrC). PMID: 27569455 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: In vivo fluorescence imaging of hepatocellular carcinoma xenograft using near-infrared labeled epidermal growth factor receptor (EGFR) peptide. PMID: 27699089 Ref: In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft. PMID: 27766208 Ref: eIF5A2 is an alternative pathway for cell proliferation in cetuximab-treated epithelial hepatocellular carcinoma. PMID: 27904670 |
Ref: Connecting cancer biology and clinical outcomes to imaging in KRAS mutant and wild-type colorectal cancer liver tumors following selective internal radiation therapy with yttrium-90. PMID: 27600383 Ref: SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. PMID: 27671677 Ref: Do directly acting antiviral agents for HCV increase the risk of hepatic decompensation and decline in renal function? Results from ERCHIVES. PMID: 27813162 Ref: TGFbeta signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells. PMID: 27862334 Ref: Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways. PMID: 27906672 Ref: Neurotensin regulation induces overexpression and activation of EGFR in HCC and restores response to erlotinib and sorafenib. PMID: 27914862 Ref: CD133 confers cancer stem-like cell properties by stabilizing EGFR-AKT signaling in hepatocellular carcinoma. PMID: 28034805 Ref: Loss of N-Acetylgalactosaminyltransferase-4 Orchestrates Oncogenic MicroRNA-9 in Hepatocellular Carcinoma. PMID: 28062574 Ref: Systematic analysis of molecular mechanisms for HCC metastasis via text mining approach. PMID: 28108733 Ref: The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma. PMID: 28114277 Ref: Long-term efficacy and safety of switching from lamivudine+adefovir to tenofovir disoproxil fumarate in virologically suppressed patients. PMID: 28179096 Ref: MicroRNA-1285 inhibits malignant biological behaviors of human pancreatic cancer cells by negative regulation of YAP1. PMID: 28253715 Ref: Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives. PMID: 28270084 Ref: Design, synthesis, and biological evaluation of novel 4-anilinoquinazoline derivatives bearing amino acid moiety as potential EGFR kinase inhibitors. PMID: 28279846 Ref: Incidence and outcomes of acute kidney injury in patients with hepatocellular carcinoma after liver transplantation. PMID: 28289896 Ref: Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells. PMID: 28423613 Ref: The identification of key genes and pathways in hepatocellular carcinoma by bioinformatics analysis of high-throughput data. PMID: 28432618 Ref: SHP2 is induced by the HBx-NF-kappaB pathway and contributes to fibrosis during human early hepatocellular carcinoma development. PMID: 28460481 Ref: Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation. PMID: 28486549 Ref: Design and synthesis of pyrazolo[3,4-d]pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma. PMID: 28487127 Ref: Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways. PMID: 28698660 Ref: Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase. PMID: 28724908 Ref: MicroRNA-374a Promotes Hepatocellular Carcinoma Cell Proliferation by Targeting Mitogen-Inducible Gene-6 (MIG-6). PMID: 28734040 Ref: Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex. PMID: 28755539 Ref: HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2. PMID: 28768863 Ref: INST OX-05-024: first line gemcitabine, oxaliplatin, and erlotinib for primary hepatocellular carcinoma and bile duct cancers: a multicenter Phase II trial. PMID: 28801995 Ref: Cell-specific mechanisms of TMEM16A Ca(2+)-activated chloride channel in cancer. PMID: 28893247 Ref: MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance. PMID: 28904393 Ref: Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. PMID: 28912543 Ref: Ultrasmall Paramagnetic Iron Oxide Nanoprobe Targeting Epidermal Growth Factor Receptor for In Vivo Magnetic Resonance Imaging of Hepatocellular Carcinoma. PMID: 28972742 Ref: Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells. PMID: 28978315 Ref: [Nuclear Her2 expression in hepatocytes in liver disease]. PMID: 29018945 Ref: Hepatoid Adenocarcinoma of the Stomach: A Challenging Diagnostic and Therapeutic Disease through a Case Report and Review of the Literature. PMID: 29034239 Ref: Effects of acute kidney injury after liver resection on long-term outcomes. PMID: 29046772 Ref: UBE2J2 promotes hepatocellular carcinoma cell epithelial-mesenchymal transition and invasion in vitro. PMID: 29069742 Ref: Establishing a colorectal cancer liver metastasis patient-derived tumor xenograft model for the evaluation of personalized chemotherapy. PMID: 29094026 Ref: Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. PMID: 29188822 Ref: Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects. PMID: 29280968 Ref: Mir-452-3p: A Potential Tumor Promoter That Targets the CPEB3/EGFR Axis in Human Hepatocellular Carcinoma. PMID: 29332449 |
Ref: The Role of Target Therapy in the Treatment of Gastrointestinal Noncolorectal Cancers: Clinical Impact and Cost Consideration. PMID: 28183250 Ref: Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo. PMID: 28833603 Ref: Heat stress induced, ligand-independent MET and EGFR signalling in hepatocellular carcinoma. PMID: 28954551 Ref: Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through beta-catenin-EGFR-PI3K-Akt-mTOR signaling pathway. PMID: 29027712 Ref: Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. PMID: 29115423 Ref: Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins. PMID: 29425759 Ref: Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array. PMID: 29438748 Ref: Common Deregulation of Seven Biological Processes by MicroRNAs in Gastrointestinal Cancers. PMID: 29459716 Ref: The ER-alpha36/EGFR signaling loop promotes growth of hepatocellular carcinoma cells. PMID: 29481815 Ref: Downregulated miR-23b-3p expression acts as a predictor of hepatocellular carcinoma progression: A study based on public data and RT-qPCR verification. PMID: 29484429 Ref: Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. PMID: 29487225 Ref: COX-2/PGE2 Axis Regulates HIF2alpha Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment. PMID: 29514844 Ref: The dual-inhibitory effect of miR-338-5p on the multidrug resistance and cell growth of hepatocellular carcinoma. PMID: 29527329 Ref: A novel matrine derivative WM622 inhibits hepatocellular carcinoma by inhibiting PI3K/AKT signaling pathways. PMID: 29532226 Ref: Integrated transcriptomic and proteomic analyses reveal a-lipoic acid-regulated cell proliferation via Grb2-mediated signalling in hepatic cancer cells. PMID: 29575431 Ref: The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III. PMID: 29587298 Ref: An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo. PMID: 29662194 Ref: HCC Specific Protein Network Involving Interactions of EGFR with A-Raf and Transthyretin: Experimental Analysis and Computational Biology Correlates. PMID: 29732980 Ref: miR372 Promotes Progression of Liver Cancer Cells by Upregulating erbB-2 through Enhancement of YB-1. PMID: 29858084 Ref: The protective mechanism of Nigella sativa against diethylnitrosamine-induced hepatocellular carcinoma through its antioxidant effect and EGFR/ERK1/2 signaling. PMID: 29923357 Ref: Mutational landscape of a chemically-induced mouse model of liver cancer. PMID: 29958939 Ref: Silencing non-SMC chromosome-associated polypeptide G inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells. PMID: 30089216 Ref: Precision oncology in liver cancer. PMID: 30105235 Ref: P57-mediated autophagy promotes the efficacy of EGFR inhibitors in hepatocellular carcinoma. PMID: 30178471 Ref: Neratinib augments the lethality of [regorafenib + sildenafil]. PMID: 30203445 Ref: Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells. PMID: 30208932 Ref: Capsaicin and sorafenib combination treatment exerts synergistic antihepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling. PMID: 30272354 Ref: Benzofuran-appended 4-aminoquinazoline hybrids as epidermal growth factor receptor tyrosine kinase inhibitors: synthesis, biological evaluation and molecular docking studies. PMID: 30274538 Ref: Design, synthesis and evaluation of novel hybrids between 4-anilinoquinazolines and substituted triazoles as potent cytotoxic agents. PMID: 30337229 Ref: Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach. PMID: 30344942 Ref: Smart nanoparticles assembled by endogenous molecules for siRNA delivery and cancer therapy via CD44 and EGFR dual-targeting. PMID: 30352311 |