Primary Site >> Liver Cancer
Gene >> E2F1
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Ref: Strain-dependent differences in DNA synthesis and gene expression in the regenerating livers of CB57BL/6J and C3H/HeJ mice. PMID: 7546224 |
Ref: Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. PMID: 9426068 |
Ref: No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. PMID: 10449036 |
Ref: Hepatitis B viral X protein overcomes inhibition of E2F1 activity by pRb on the human Rb gene promoter. PMID: 11244564 Ref: Use of chromatin immunoprecipitation to clone novel E2F target promoters. PMID: 11564866 |
Ref: E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models. PMID: 12593856 Ref: Transcriptional repression of the human p53 gene by hepatitis B viral core protein (HBc) in human liver cells. PMID: 12675512 Ref: Association of over-expressed TFDP1 with progression of hepatocellular carcinomas. PMID: 14618416 |
Ref: Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells. PMID: 14604889 Ref: Disregulation of E-cadherin in transgenic mouse models of liver cancer. PMID: 15220935 Ref: Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis. PMID: 15313206 Ref: Application of comparative functional genomics to identify best-fit mouse models to study human cancer. PMID: 15565109 |
Ref: Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. PMID: 15885355 Ref: In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells. PMID: 16299255 |
Ref: Gene expression profile of DNA binding protein A transgenic mice. PMID: 16865284 Ref: Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis. PMID: 17006931 |
Ref: Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. PMID: 17575144 Ref: Effects and mechanisms of silibinin on human hepatoma cell lines. PMID: 17879397 |
Ref: Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. PMID: 18606816 Ref: Activation of B-Myb by E2F1 in hepatocellular carcinoma. PMID: 18624722 Ref: Genetic control of resistance to hepatocarcinogenesis by the mouse Hpcr3 locus. PMID: 18666244 Ref: E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. PMID: 18722373 Ref: Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. PMID: 18765544 Ref: In-vivo effects and mechanisms of celecoxib-reduced growth of cyclooxygenase-2 (COX-2)-expressing versus COX-2-deleted human HCC xenografts in nude mice. PMID: 18766003 |
Ref: Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels. PMID: 19041685 Ref: Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice. PMID: 19399925 Ref: Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma. PMID: 19486339 Ref: Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. PMID: 19690140 |
Ref: Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation. PMID: 19656618 Ref: Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation. PMID: 19828754 Ref: Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control. PMID: 19887370 Ref: Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor-promoting effects in mice. PMID: 20101389 Ref: Serum response factor depletion affects the proliferation of the hepatocellular carcinoma cells HepG2 and JHH6. PMID: 20144681 Ref: miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. PMID: 20209605 Ref: Time series analysis of benzo[A]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets. PMID: 20624995 Ref: An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer. PMID: 20962331 |
Ref: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype. PMID: 21419759 Ref: Hepatitis B virus X protein regulates the mEZH2 promoter via the E2F1-binding site in AML12 cells. PMID: 21439249 Ref: Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53. PMID: 21480327 Ref: Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARalpha-independent mechanisms. PMID: 21514001 Ref: Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation. PMID: 21757290 Ref: Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells. PMID: 21831731 |
Ref: Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression. PMID: 22318685 Ref: HBx protein of hepatitis B virus promotes reinitiation of DNA replication by regulating expression and intracellular stability of replication licensing factor CDC6. PMID: 22523071 Ref: Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway. PMID: 22641337 |
Ref: The E2F transcription factor 1 transactives stathmin 1 in hepatocellular carcinoma. PMID: 22911364 Ref: Sasanquasaponin from Camellia oleifera Abel. induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells. PMID: 23164604 Ref: Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. PMID: 23212661 Ref: HBV core promoter mutations promote cellular proliferation through E2F1-mediated upregulation of S-phase kinase-associated protein 2 transcription. PMID: 23348237 Ref: RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats. PMID: 23630614 Ref: Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ERalpha in mouse livers. PMID: 23684557 Ref: E2F transcription factors and digestive system malignancies: how much do we know? PMID: 23745020 Ref: Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment. PMID: 23868976 Ref: Hepatic loss of miR-122 predisposes mice to hepatobiliary cyst and hepatocellular carcinoma upon diethylnitrosamine exposure. PMID: 24113455 Ref: iSubgraph: integrative genomics for subgroup discovery in hepatocellular carcinoma using graph mining and mixture models. PMID: 24223834 |
Ref: Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2. PMID: 24038073 Ref: Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma. PMID: 24336972 Ref: Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma. PMID: 24337632 Ref: TFDP3 was expressed in coordination with E2F1 to inhibit E2F1-mediated apoptosis in prostate cancer. PMID: 24406621 Ref: Promising roles of mammalian E2Fs in hepatocellular carcinoma. PMID: 24440307 Ref: Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines. PMID: 24574752 Ref: Aflatoxin B1 promotes cell growth and invasion in hepatocellular carcinoma HepG2 cells through H19 and E2F1. PMID: 24761865 Ref: Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma. PMID: 24824848 Ref: The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma. PMID: 24845612 Ref: miR-106b-25/miR-17-92 clusters: polycistrons with oncogenic roles in hepatocellular carcinoma. PMID: 24876719 Ref: The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells. PMID: 24882622 Ref: EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. PMID: 24916103 Ref: Specific genomic and transcriptomic aberrations in tumors induced by partial hepatectomy of a chronically inflamed murine liver. PMID: 25401338 |
Ref: Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4. PMID: 24572141 Ref: A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients. PMID: 25500144 Ref: Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells. PMID: 25742740 Ref: Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F. PMID: 25893635 Ref: MiR-429 increases the metastatic capability of HCC via regulating classic Wnt pathway rather than epithelial-mesenchymal transition. PMID: 25931210 Ref: Hepatitis B virus induces RNR-R2 expression via DNA damage response activation. PMID: 26026873 Ref: Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver. PMID: 26171734 Ref: HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells. PMID: 26358750 Ref: Cannabinoid WIN55, 212-2 induces cell cycle arrest and inhibits the proliferation and migration of human BEL7402 hepatocellular carcinoma cells. PMID: 26500101 Ref: POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. PMID: 26510456 Ref: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. PMID: 26639898 |
Ref: Elevated Expression of Hepatoma Up-Regulated Protein Inhibits gamma-Irradiation-Induced Apoptosis of Prostate Cancer Cells. PMID: 26505164 Ref: Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). PMID: 26540633 Ref: Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis. PMID: 26596832 Ref: Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma. PMID: 26722215 Ref: NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism. PMID: 26724859 Ref: Intestine-specific homeobox (ISX) upregulates E2F1 expression and related oncogenic activities in HCC. PMID: 27175585 Ref: Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression. PMID: 27351279 Ref: Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression. PMID: 27486509 Ref: A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells. PMID: 27525972 Ref: Downregulation of FOXP1 Inhibits Cell Proliferation in Hepatocellular Carcinoma by Inducing G1/S Phase Cell Cycle Arrest. PMID: 27618020 Ref: Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. PMID: 27646854 Ref: HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression. PMID: 27779207 |
Ref: The Role of the Transcription Factor E2F1 in Hepatocellular Carcinoma. PMID: 27109336 Ref: Growth factor receptor binding protein 14 inhibition triggers insulin-induced mouse hepatocyte proliferation and is associated with hepatocellular carcinoma. PMID: 27981611 Ref: Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. PMID: 28003426 Ref: Galactosylated polyaspartamide copolymers for siRNA targeted delivery to hepatocellular carcinoma cells. PMID: 28119125 Ref: Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. PMID: 28134624 Ref: Dissecting the role of the elongation factor 1A isoforms in hepatocellular carcinoma cells by liposome-mediated delivery of siRNAs. PMID: 28229942 Ref: Derivate Isocorydine (d-ICD) Suppresses Migration and Invasion of Hepatocellular Carcinoma Cell by Downregulating ITGA1 Expression. PMID: 28264467 Ref: From big data to diagnosis and prognosis: gene expression signatures in liver hepatocellular carcinoma. PMID: 28316892 Ref: Aryl hydrocarbon receptor promotes hepatocellular carcinoma tumorigenesis by targeting intestine-specific homeobox expression. PMID: 28398627 Ref: A novel lncRNA, GASL1, inhibits cell proliferation and restricts E2F1 activity. PMID: 28423601 Ref: Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines. PMID: 28572744 Ref: E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma. PMID: 28607595 Ref: Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression. PMID: 28716136 Ref: Celastrol downregulates E2F1 to induce growth inhibitory effects in hepatocellular carcinoma HepG2 cells. PMID: 29048668 Ref: MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis. PMID: 29179453 Ref: High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells. PMID: 29218329 |
Ref: E2F is involved in radioresistance of carbon ion induced apoptosis via Bax/caspase 3 signal pathway in human hepatoma cell. PMID: 28500630 Ref: Nanocurcumin-Mediated Down-Regulation of Telomerase Via Stimulating TGFbeta1 Signaling Pathway in Hepatocellular Carcinoma Cells PMID: 28992682 Ref: Prevalence of Aflatoxin-Associated TP53R249S Mutation in Hepatocellular Carcinoma in Hispanics in South Texas. PMID: 29089331 Ref: SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1. PMID: 29115436 Ref: Effective Timing of Surgical Resection of Colorectal Cancer Liver Metastases During Chemotherapy. PMID: 29374697 Ref: Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas. PMID: 29672926 Ref: Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer. PMID: 30082483 Ref: SET7/9 promotes hepatocellular carcinoma progression through regulation of E2F1. PMID: 30106440 Ref: MicroRNA-34a Promotes MICB Expression in Hepatocytes. PMID: 30256916 Ref: Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma. PMID: 30344945 |