Primary Site >> Colorectal Cancer

Gene >> DOT1L

  • 2010
  • 2014
  • 2015
  • 2017
Ref: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/beta-catenin coactivators essential for intestinal homeostasis.
PMID: 21103407
Ref: IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.
PMID: 24816405
Ref: Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.
PMID: 25361163
Ref: Targeting histone methylation for colorectal cancer.
PMID: 28286564