Primary Site >> Pancreatic Cancer
Gene >> DNMT3A
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Ref: Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. PMID: 18492726 |
Ref: Silencing of BNIP3 results from promoter methylation by DNA methyltransferase 1 induced by the mitogen-activated protein kinase pathway. PMID: 21573703 Ref: Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer. PMID: 22110720 |
Ref: Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma. PMID: 22301400 |
Ref: Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways. PMID: 25152840 |
Ref: Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries. PMID: 25621113 |
Ref: Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK. PMID: 26782786 |
Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 |
Ref: DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53deficient pancreatic cancer cells. PMID: 29115606 Ref: Downregulation of miR29b targets DNMT3b to suppress cellular apoptosis and enhance proliferation in pancreatic cancer. PMID: 29207141 Ref: Nicotine induces aberrant hypermethylation of tumor suppressor genes in pancreatic epithelial ductal cells. PMID: 29626481 |