Primary Site >> Colorectal Cancer
Gene >> DNMT3A
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Ref: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. PMID: 10344733 |
Ref: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. PMID: 12496760 Ref: Mitoxantrone mediates demethylation and reexpression of cyclin d2, estrogen receptor and 14.3.3sigma in breast cancer cells. PMID: 12878861 |
Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Procainamide is a specific inhibitor of DNA methyltransferase 1. PMID: 16230360 |
Ref: De novo CpG island methylation in human cancer cells. PMID: 16423997 Ref: Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription. PMID: 16735507 Ref: [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. PMID: 17236547 |
Ref: Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence. PMID: 17538945 |
Ref: 5-Aza-2'-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells. PMID: 18848767 Ref: Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. PMID: 19454286 Ref: MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. PMID: 19638978 Ref: DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. PMID: 19723660 |
Ref: Recent insights into the pathogenesis of colorectal cancer. PMID: 19786869 Ref: Epigenetic regulation of the ERbeta gene on the estrogen signal transfection pathway in colon cancer cells. PMID: 20155458 Ref: Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. PMID: 20543577 |
Ref: DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. PMID: 20473858 |
Ref: Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer. PMID: 22740930 |
Ref: Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells. PMID: 24324066 Ref: DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma. PMID: 24649006 |
Ref: Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer. PMID: 24282031 Ref: DNA methyltransferases: a novel target for prevention and therapy. PMID: 24822169 Ref: Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer. PMID: 24887488 Ref: MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism. PMID: 25272045 |
Ref: Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a. PMID: 24837369 Ref: DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis. PMID: 25966133 Ref: Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line. PMID: 26133168 Ref: Association of DNA methyltransferases expression with global and gene-specific DNA methylation in colorectal cancer cells. PMID: 26416384 Ref: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. PMID: 26458736 |
Ref: A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division. PMID: 27077950 Ref: Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. PMID: 27666771 |
Ref: Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-beta1. PMID: 28098901 Ref: The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry. PMID: 28149332 Ref: Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells. PMID: 28463515 Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 Ref: PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer. PMID: 28619512 Ref: miR-148a inhibits colitis and colitis-associated tumorigenesis in mice. PMID: 28960206 |
Ref: LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A. PMID: 29278853 Ref: The impact of polyunsaturated fatty acids on DNA methylation and expression of DNMTs in human colorectal cancer cells. PMID: 29477476 Ref: Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers. PMID: 29641532 Ref: Adipose tissue inflammation and VDR expression and methylation in colorectal cancer. PMID: 29719581 Ref: Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis. PMID: 29730197 Ref: Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report. PMID: 29876008 |