Primary Site >> Colorectal Cancer
Gene >> DNMT1
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Ref: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. PMID: 10344733 Ref: Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. PMID: 10463569 |
Ref: CpG methylation is maintained in human cancer cells lacking DNMT1. PMID: 10801130 Ref: Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. PMID: 10919675 |
Ref: DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. PMID: 11146446 |
Ref: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. PMID: 11932749 Ref: Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. PMID: 12438232 |
Ref: A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase. PMID: 12477724 Ref: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. PMID: 12496760 Ref: Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. PMID: 12538344 Ref: Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. PMID: 12538347 Ref: The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. PMID: 12769777 Ref: Epigenetic inactivation of CHFR in human tumors. PMID: 12810945 Ref: Mitoxantrone mediates demethylation and reexpression of cyclin d2, estrogen receptor and 14.3.3sigma in breast cancer cells. PMID: 12878861 Ref: Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. PMID: 12915469 Ref: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. PMID: 14583449 Ref: Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. PMID: 14633667 |
Ref: [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. PMID: 15059516 Ref: CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. PMID: 15156141 Ref: [Effect of eukaryotic expression plasmid DNA methyltransferase gene on methylation status and transcription level of DNA mismatch repair genes in human colon cancer cell line]. PMID: 15312538 Ref: Doxorubicin inhibits DNMT1, resulting in conditional apoptosis. PMID: 15340041 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. PMID: 15867357 Ref: Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. PMID: 15885659 Ref: Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. PMID: 16174748 Ref: Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. PMID: 16204030 Ref: Procainamide is a specific inhibitor of DNA methyltransferase 1. PMID: 16230360 |
Ref: De novo CpG island methylation in human cancer cells. PMID: 16423997 Ref: Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation. PMID: 16424002 Ref: Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1. PMID: 16473673 Ref: Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. PMID: 16568088 Ref: Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b. PMID: 16715135 Ref: Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription. PMID: 16735507 Ref: [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. PMID: 17236547 |
Ref: Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. PMID: 16624484 Ref: Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues. PMID: 17093909 Ref: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. PMID: 17307743 Ref: Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. PMID: 17322882 Ref: Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. PMID: 17443689 Ref: Progressive up-regulation of genes encoding DNA methyltransferases in the colorectal adenoma-carcinoma sequence. PMID: 17538945 Ref: Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer. PMID: 17657744 Ref: DNA methylation regulates MicroRNA expression. PMID: 17660710 Ref: Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. PMID: 18089774 |
Ref: 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. PMID: 18198215 Ref: p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. PMID: 18223691 Ref: Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer. PMID: 18327804 Ref: Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. PMID: 18332107 Ref: SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2'deoxycytidine to increase SPARC expression and improve therapy response. PMID: 18458674 Ref: DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. PMID: 19074829 |
Ref: Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. PMID: 18789002 Ref: DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers. PMID: 19156137 Ref: Possible involvement of activation of P53/P21 and demethylation of RUNX 3 in the cytotoxicity against Lovo cells induced by 5-Aza-2'-deoxycytidine. PMID: 19159630 Ref: Combined inhibition of Dnmt and mTOR signaling inhibits formation and growth of colorectal cancer. PMID: 19229543 Ref: Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. PMID: 19569244 Ref: 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats. PMID: 19723570 Ref: DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. PMID: 19723660 Ref: Effects of amino acid substitution polymorphisms of two DNA methyltransferases on susceptibility to sporadic colorectal cancer. PMID: 20192566 |
Ref: TSA-induced DNMT1 down-regulation represses hTERT expression via recruiting CTCF into demethylated core promoter region of hTERT in HCT116. PMID: 19914212 Ref: Epigenetic regulation of the ERbeta gene on the estrogen signal transfection pathway in colon cancer cells. PMID: 20155458 Ref: Impact of genomic methylation on radiation sensitivity of colorectal carcinoma. PMID: 20338477 Ref: Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6. PMID: 20354000 Ref: HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors. PMID: 20454457 Ref: Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells. PMID: 20543577 Ref: Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription. PMID: 20562909 Ref: Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis. PMID: 20588031 Ref: DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. PMID: 21045206 Ref: [Effect and mechanism of DNMT inhibitor on the reversal of multidrug resistance in human colon cancer cell line sw620/L-OHP]. PMID: 21265097 |
Ref: DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells. PMID: 20473858 Ref: Epigenetic modifications and human pathologies: cancer and CVD. PMID: 21067630 Ref: Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. PMID: 21123457 Ref: Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines. PMID: 21408221 Ref: Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PMID: 21526191 Ref: Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations. PMID: 21537397 Ref: Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway. PMID: 21551187 Ref: MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. PMID: 21565830 Ref: DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response. PMID: 21636528 Ref: Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing. PMID: 21785137 Ref: Molecular basis for the actions of Hsp90 inhibitors and cancer therapy. PMID: 21811259 Ref: Synthesis and biochemical evaluation of delta(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors. PMID: 21958292 |
Ref: Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3. PMID: 22274925 Ref: DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes. PMID: 22278882 Ref: Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells. PMID: 22415137 Ref: Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity. PMID: 22595877 Ref: IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer. PMID: 22739025 Ref: Chemotherapy and radiotherapy downregulate the activity and expression of DNA methyltransferase and enhance Bcl-2/E1B-19-kDa interacting protein-3-induced apoptosis in human colorectal cancer cells. PMID: 23364257 |
Ref: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. PMID: 22961839 Ref: DNA methyltransferase 1 is essential for initiation of the colon cancers. PMID: 23064049 Ref: Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner. PMID: 23072722 Ref: Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. PMID: 23368921 Ref: Epigenetic effects of the natural flavonolignan silibinin on colon adenocarcinoma cells and their derived metastatic cells. PMID: 23599778 Ref: Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells. PMID: 23618814 Ref: Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1. PMID: 23639684 Ref: Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers. PMID: 23717604 Ref: Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. PMID: 24225777 Ref: Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. PMID: 24289550 Ref: Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells. PMID: 24324066 |
Ref: The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. PMID: 23708667 Ref: Different effects of epigenetic modifiers on the cytotoxicity induced by 5-fluorouracil, irinotecan or oxaliplatin in colon cancer cells. PMID: 24172061 Ref: IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway. PMID: 24464786 Ref: Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate. PMID: 24518414 Ref: DNA methyltransferase inhibitors improve the effect of chemotherapeutic agents in SW48 and HT-29 colorectal cancer cells. PMID: 24676085 Ref: DNA methyltransferases: a novel target for prevention and therapy. PMID: 24822169 Ref: Promoter methylation analysis of WNT/beta-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer. PMID: 25107489 Ref: Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions. PMID: 25207720 Ref: Label-free electrochemical detection of human methyltransferase from tumors. PMID: 25288757 Ref: Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity--a short report. PMID: 25450519 |
Ref: PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas. PMID: 25454821 Ref: DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. PMID: 25595591 Ref: Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells. PMID: 25695131 Ref: A Protein Interaction between beta-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells. PMID: 25753001 Ref: The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines. PMID: 25804133 Ref: Identification of radiation-induced aberrant hypomethylation in colon cancer. PMID: 25887185 Ref: Synthesis, chemical characterization, computational studies and biological activity of new DNA methyltransferases (DNMTs) specific inhibitor. Epigenetic regulation as a new and potential approach to cancer therapy. PMID: 26072325 Ref: Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study. PMID: 26108676 Ref: DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors. PMID: 26120002 Ref: Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells. PMID: 26179333 Ref: Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer. PMID: 26305882 Ref: DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer. PMID: 26307088 Ref: Association of DNA methyltransferases expression with global and gene-specific DNA methylation in colorectal cancer cells. PMID: 26416384 Ref: Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity. PMID: 26439130 Ref: Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases. PMID: 26458736 Ref: miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1. PMID: 26497367 Ref: Acquired resistance to decitabine and cross-resistance to gemcitabine during the long-term treatment of human HCT116 colorectal cancer cells with decitabine. PMID: 26622566 |
Ref: Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage. PMID: 26186941 Ref: DNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation. PMID: 26883721 Ref: Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response. PMID: 27143627 Ref: DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis. PMID: 27356727 Ref: Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer. PMID: 27666771 Ref: Arsenic trioxide induces cell cycle arrest and alters DNA methylation patterns of cell cycle regulatory genes in colorectal cancer cells. PMID: 27769816 |
Ref: Reelin-Dab1 signaling system in human colorectal cancer. PMID: 27434856 Ref: Induction of Epigenetic Alteration by CPUK02, An Ent- kaurenoid Derivative of Stevioside. PMID: 28090275 Ref: Effect of evodiamine and berberine on the interaction between DNMTs and target microRNAs during malignant transformation of the colon by TGF-beta1. PMID: 28098901 Ref: Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells. PMID: 28241740 Ref: Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer. PMID: 28300471 Ref: Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells. PMID: 28463515 Ref: Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer. PMID: 28583846 Ref: Chemoresistance of colorectal cancer to 5-fluorouracil is associated with silencing of the BNIP3 gene through aberrant methylation. PMID: 28607593 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Clinical and prognosis value of the CIMP status combined with MLH1 or p16 (INK4a) methylation in colorectal cancer. PMID: 28730335 |
Ref: DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment. PMID: 29199082 Ref: The impact of polyunsaturated fatty acids on DNA methylation and expression of DNMTs in human colorectal cancer cells. PMID: 29477476 Ref: Mutant KRAS promotes liver metastasis of colorectal cancer, in part, by upregulating the MEK-Sp1-DNMT1-miR-137-YB-1-IGF-IR signaling pathway. PMID: 29559746 Ref: Inhibition of DNMT suppresses the stemness of colorectal cancer cells through down-regulating Wnt signaling pathway. PMID: 29601907 Ref: NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer. PMID: 29608915 Ref: Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells. PMID: 29854080 Ref: Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development. PMID: 29899856 Ref: Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer. PMID: 29901158 Ref: The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. PMID: 29966255 Ref: Curvature-Mediated Surface Accessibility Enables Ultrasensitive Electrochemical Human Methyltransferase Analysis. PMID: 30080023 |