Primary Site >> Colorectal Cancer
Gene >> DLL4
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Ref: Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. PMID: 16525728 |
Ref: Notch signaling in gastrointestinal tract (review). PMID: 17143535 |
Ref: Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy. PMID: 19208840 Ref: Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. PMID: 19844231 |
Ref: Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. PMID: 21193546 Ref: Notch3 signalling promotes tumour growth in colorectal cancer. PMID: 21598247 Ref: Delta-like ligand 4-notch blockade and tumor radiation response. PMID: 22010178 |
Ref: Genetic polymorphism in a VEGF-independent angiogenesis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection. PMID: 22496856 |
Ref: Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. PMID: 24185040 |
Ref: NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells. PMID: 24525742 Ref: Dll4-notch signalling blockade synergizes combined ultrasound-stimulated microbubble and radiation therapy in human colon cancer xenografts. PMID: 24736631 Ref: Antagonism of Ang-Tie2 and Dll4-Notch signaling has opposing effects on tumor endothelial cell proliferation, evidenced by a new flow cytometry method. PMID: 25243900 |
Ref: Expression of delta-like 4 (Drosophila) and vascular endothelial growth factor A in colon cancer and association with tumour angiogenesis. PMID: 26111775 Ref: HDAC5 promotes colorectal cancer cell proliferation by up-regulating DLL4 expression. PMID: 26131280 Ref: Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival. PMID: 26394830 |
Ref: Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth. PMID: 27880939 Ref: Delta-like 4/Notch signaling promotes Apc (Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms. PMID: 28086833 Ref: Metformin depresses overactivated Notch1/Hes1 signaling in colorectal cancer patients with type 2 diabetes mellitus. PMID: 28177944 |
Ref: Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer. PMID: 29879147 Ref: Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. PMID: 29899427 |