Primary Site >> Colorectal Cancer
Gene >> DKK2
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Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. PMID: 17675336 |
Ref: DNA methylation as an epigenetic biomarker in colorectal cancer. PMID: 24260063 |
Ref: Association of common gene variants in the WNT/beta-catenin pathway with colon cancer recurrence. PMID: 23817222 Ref: A functional germline variant in GLI1 implicates hedgehog signaling in clinical outcome of stage II and III colon carcinoma patients. PMID: 24470513 Ref: DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/beta-catenin signaling pathway genes. PMID: 24811787 Ref: Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer. PMID: 25139296 Ref: Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists. PMID: 25432628 |
Ref: MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition. PMID: 27668319 |
Ref: Dickkopf-Related Protein 2 is Epigenetically Inactivated and Suppresses Colorectal Cancer Growth and Tumor Metastasis by Antagonizing Wnt/beta-Catenin Signaling. PMID: 28365691 Ref: Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa. PMID: 28533824 |
Ref: DKK2 imparts tumor immunity evasion through beta-catenin-independent suppression of cytotoxic immune-cell activation. PMID: 29431745 Ref: Gene promoter and exon DNA methylation changes in colon cancer development - mRNA expression and tumor mutation alterations. PMID: 29945573 Ref: In Silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N terminal domain of Dickkopf 2 in contrary to other Dickkopfs facilitates its interaction with Low Density Lipoprotein Receptor Related Protein 5/6. PMID: 30035709 |