Primary Site >> Colorectal Cancer
Gene >> DKK1
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Ref: An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. PMID: 15542433 |
Ref: The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. PMID: 15592505 Ref: Comparative genomics on SFRP1 orthologs. PMID: 16077939 Ref: Comparative genomics on SFRP2 orthologs. PMID: 16077992 |
Ref: WNT antagonist, SFRP1, is Hedgehog signaling target. PMID: 16328026 Ref: Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. PMID: 16491118 Ref: Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. PMID: 16708370 |
Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. PMID: 17390031 Ref: The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. PMID: 17449905 Ref: Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. PMID: 17635998 Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. PMID: 17675336 Ref: Turning the tables: Myc activates Wnt in breast cancer. PMID: 17726380 |
Ref: Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. PMID: 18461655 Ref: Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. PMID: 18542073 Ref: Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. PMID: 18716850 Ref: Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes. PMID: 19035286 |
Ref: Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells. PMID: 19059704 Ref: Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf. PMID: 19378335 Ref: Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer. PMID: 19628661 Ref: Networking of differentially expressed genes in human cancer cells resistant to methotrexate. PMID: 19732436 |
Ref: A five-gene signature as a potential predictor of metastasis and survival in colorectal cancer. PMID: 20077526 Ref: Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. PMID: 20395289 Ref: 5-Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells. PMID: 20800023 Ref: The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling. PMID: 21317455 |
Ref: Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. PMID: 21304055 Ref: Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation. PMID: 21683813 Ref: Relationship between clinicopathologic variables and serum and tissue levels of dickkopf-1 in patients with rectal cancer. PMID: 21712726 Ref: S100A4-induced cell motility and metastasis is restricted by the Wnt/beta-catenin pathway inhibitor calcimycin in colon cancer cells. PMID: 21795396 Ref: Lack of diagnostic potential of Dickkopf-1 in colon and rectum cancers. PMID: 22471451 |
Ref: Dickkopf-1 inhibits epithelial-mesenchymal transition of colon cancer cells and contributes to colon cancer suppression. PMID: 22321022 Ref: Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line. PMID: 22815877 Ref: Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients. PMID: 22966878 |
Ref: 2,3,6-Trisubstituted quinoxaline derivative, a small molecule inhibitor of the Wnt/beta-catenin signaling pathway, suppresses cell proliferation and enhances radiosensitivity in A549/Wnt2 cells. PMID: 23348226 Ref: [Expression of Dickkopf-1 in human colon carcinoma cell lines]. PMID: 23803213 Ref: Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/beta-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]. PMID: 23922913 Ref: Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice. PMID: 24204690 |
Ref: Prognostic significance of dickkopf-1 overexpression in solid tumors: a meta-analysis. PMID: 24258111 Ref: High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PMID: 24427302 Ref: The role of preoperative serum levels for Dickkopf-related protein 1 as a potential marker of tumor invasion in patients with stage II and III colon cancer. PMID: 24992617 Ref: SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/beta-catenin signaling pathway. PMID: 25150783 Ref: Wnt3a expression is associated with epithelial-mesenchymal transition and promotes colon cancer progression. PMID: 25499541 |
Ref: Dickkopf-1 expression is down-regulated during the colorectal adenoma-carcinoma sequence and correlates with reduced microvessel density and VEGF expression. PMID: 24916146 Ref: EYA4 Acts as a New Tumor Suppressor Gene in Colorectal Cancer. PMID: 25620232 Ref: Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. PMID: 25788273 Ref: Vitamin D3 enhances the tumouricidal effects of 5-Fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer. PMID: 26205949 Ref: FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. PMID: 26264222 Ref: Wnt3a Promotes the Vasculogenic Mimicry Formation of Colon Cancer via Wnt/beta-Catenin Signaling. PMID: 26266404 Ref: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer. PMID: 26296979 |
Ref: Paricalcitol Enhances the Chemopreventive Efficacy of 5-Fluorouracil on an Intermediate-Term Model of Azoxymethane-Induced Colorectal Tumors in Rats. PMID: 27020656 Ref: Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. PMID: 27245242 Ref: Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats. PMID: 27468227 |
Ref: ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. PMID: 27965283 Ref: CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. PMID: 28229932 Ref: Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding. PMID: 28337306 Ref: Methylation of WNT target genes AXIN2 and DKK1 as robust biomarkers for recurrence prediction in stage II colon cancer. PMID: 28368388 Ref: Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene. PMID: 28468585 Ref: Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model. PMID: 28708837 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: miR-590-3p promotes colon cancer cell proliferation via Wnt/beta-catenin signaling pathway by inhibiting WIF1 and DKK1. PMID: 29164578 Ref: Therapeutic strategies against cancer stem cells in human colorectal cancer. PMID: 29250169 |
Ref: Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells. PMID: 29682205 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: In Silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N terminal domain of Dickkopf 2 in contrary to other Dickkopfs facilitates its interaction with Low Density Lipoprotein Receptor Related Protein 5/6. PMID: 30035709 Ref: LncRNA HOTTIP mediated DKK1 downregulation confers metastasis and invasion in colorectal cancer cells. PMID: 30229808 |