Primary Site >> Colorectal Cancer
Gene >> DIABLO
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Ref: A multicenter study of colorectal adenomas. Rationale, objectives, methods and characteristics of the study cohort. The Multicentric Study of Colorectal Adenomas (SMAC) Workgroup. PMID: 7571020 |
Ref: Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. PMID: 12670894 Ref: Interobserver agreement in the histologic diagnosis of colorectal polyps. the experience of the multicenter adenoma colorectal study (SMAC). PMID: 12725874 Ref: Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas. PMID: 12752217 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 Ref: Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. PMID: 12941843 |
Ref: Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis. PMID: 14604899 Ref: Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. PMID: 15205359 Ref: SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells. PMID: 15557007 Ref: Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. PMID: 15623604 |
Ref: Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. PMID: 15661804 Ref: Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. PMID: 15671246 Ref: Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells. PMID: 15754004 Ref: [Frequent epigenetic inactivation of XAF1 by promotor hypermethylation in human colon cancers]. PMID: 15843754 Ref: Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. PMID: 15905197 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. PMID: 16103097 |
Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. PMID: 16998592 |
Ref: Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. PMID: 17182797 Ref: SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events. PMID: 17237824 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Smac/DIABLO and colon cancer. PMID: 17630921 Ref: Induction of apoptosis in HT-29 colon cancer cells by phloretin. PMID: 18158826 |
Ref: MnSOD protects colorectal cancer cells from TRAIL-induced apoptosis by inhibition of Smac/DIABLO release. PMID: 17653087 Ref: SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release. PMID: 18172320 Ref: Ceramide induces release of mitochondrial proapoptotic proteins in caspase-dependent and -independent manner in HT-29 cells. PMID: 18176793 Ref: [Smac as a predictive marker of tumor response to preoperative radiotherapy in rectal cancer]. PMID: 18279617 Ref: Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. PMID: 18485277 Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. PMID: 18560353 Ref: The response of human colonocytes to folate deficiency in vitro: functional and proteomic analyses. PMID: 18597513 |
Ref: Apoptosis-inducing factor and colon cancer. PMID: 18061616 Ref: Clinical significance of Smac/DIABLO expression in colorectal cancer. PMID: 19148507 Ref: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. PMID: 19154411 Ref: Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. PMID: 19264955 Ref: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. PMID: 19426686 Ref: 3,3'-diindolylmethane enhances the efficacy of butyrate in colon cancer prevention through down-regulation of survivin. PMID: 19470789 Ref: Immunoexpression of inhibitors of apoptosis proteins and their antagonist SMAC/DIABLO in colorectal carcinoma: correlation with apoptotic index, cellular proliferation and prognosis. PMID: 19578769 Ref: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. PMID: 19638488 Ref: trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. PMID: 19857056 Ref: Smac deficiency affects endoplasmic reticulum stress-induced apoptosis in human colon cancer cells. PMID: 20209078 Ref: Sulindac Sulfide Differentially Induces Apoptosis in Smac-Proficient and -Deficient Human Colon Cancer Cells. PMID: 20419043 |
Ref: In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201. PMID: 20633731 Ref: Fucoidan present in brown algae induces apoptosis of human colon cancer cells. PMID: 20727207 Ref: Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. PMID: 21041628 Ref: XIAP impairs Smac release from the mitochondria during apoptosis. PMID: 21364655 Ref: Predictive value of Smac, VEGF and Ki-67 in rectal cancer treated with neoadjuvant therapy. PMID: 22966357 |
Ref: Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer. PMID: 21264751 Ref: Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization. PMID: 21354220 Ref: Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. PMID: 21372226 Ref: Calbindin 2 (CALB2) regulates 5-fluorouracil sensitivity in colorectal cancer by modulating the intrinsic apoptotic pathway. PMID: 21629658 |
Ref: Prognostic value of Smac expression in rectal cancer patients treated with neoadjuvant therapy. PMID: 21264534 Ref: Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. PMID: 22018732 Ref: Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy. PMID: 22082587 Ref: Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer. PMID: 22481083 Ref: Ursodeoxycholic acid protects colon cancer HCT116 cells from deoxycholic acid-induced apoptosis by inhibiting apoptosome formation. PMID: 22497644 Ref: Lentivirus-mediated RNAi knockdown of VEGFA in RKO colorectal cancer cells decreases tumor formation and growth in vitro and in vivo. PMID: 22670172 Ref: Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization. PMID: 23038270 |
Ref: An apoptosis-independent role of SMAC in tumor suppression. PMID: 22751125 Ref: Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging. PMID: 23729364 |
Ref: Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression. PMID: 24422988 Ref: CLIC4, ERp29, and Smac/DIABLO derived from metastatic cancer stem-like cells stratify prognostic risks of colorectal cancer. PMID: 24916695 Ref: EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells. PMID: 25198428 Ref: Smac/DIABLO expression in human gastrointestinal carcinoma: Association with clinicopathological parameters and survivin expression. PMID: 25364431 |
Ref: Antimicrobial peptide m2163 or m2386 identified from Lactobacillus casei ATCC 334 can trigger apoptosis in the human colorectal cancer cell line SW480. PMID: 25557887 Ref: USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics. PMID: 25613375 Ref: High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer. PMID: 26071313 Ref: LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging. PMID: 26318819 Ref: A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. PMID: 26333381 Ref: The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. PMID: 26383618 |
Ref: Cooperative TRAIL production mediates IFNalpha/Smac mimetic-induced cell death in TNFalpha-resistant solid cancer cells. PMID: 26788912 Ref: Effects of autophagy regulation of tumor-associated macrophages on radiosensitivity of colorectal cancer cells. PMID: 26821367 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy. PMID: 27166192 Ref: IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis. PMID: 27520705 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 |
Ref: Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells. PMID: 27889570 Ref: Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. PMID: 28476895 |
Ref: Cationic liposome co-encapsulation of SMAC mimetic and zVAD using a novel lipid bilayer fusion loaded with MLKL-pDNA for tumour inhibition in vivo. PMID: 28649853 |