Primary Site >> Colorectal Cancer

Gene >> DHODH

  • 1990
  • 2010
  • 2014
  • 2017
Ref: Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
PMID: 2153375
 Ref: Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis.
PMID: 20399851
 Ref: The Role of Dihydroorotate Dehydrogenase in Apoptosis Induction in Response to Inhibition of the Mitochondrial Respiratory Chain Complex III.
PMID: 24772329
 Ref: Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells.
PMID: 28196676