Primary Site >> Colorectal Cancer
Gene >> DHFR
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Ref: Sequence analysis of a human gene responsible for drug resistance: a rapid method for manual and automated direct sequencing of products generated by the polymerase chain reaction. PMID: 2698661 Ref: Amplification of a polymorphic dihydrofolate reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon carcinoma cell line, HCT-8R4, resistant to this drug. PMID: 2914962 |
Ref: Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues. PMID: 8449831 |
Ref: Determinants of trimetrexate lethality in human colon cancer cells. PMID: 7981057 |
Ref: [Stimulation of differentiation of LIM 1215 large intestinal tumor cells during expression of the p53 exogenous antioncogene or the activated ras oncogene]. PMID: 8579493 |
Ref: Tomudex (ZD1694): from concept to care, a programme in rational drug discovery. PMID: 8958186 |
Ref: DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair. PMID: 9294177 |
Ref: Resistance to high concentrations of methotrexate and 5-fluorouracil of differentiated HT-29 colon-cancer cells is restricted to cells of enterocytic phenotype. PMID: 9579576 Ref: Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523). PMID: 9857098 |
Ref: A phase I evaluation of multitargeted antifolate (MTA, LY231514), administered every 21 days, utilizing the modified continual reassessment method for dose escalation. PMID: 10501910 |
Ref: Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates. PMID: 10956384 |
Ref: Investigations on the biological properties of the lipophilic DHFR-inhibitory benzoprims reveal non-folate modes of action and opportunities for anti-cancer drug design. PMID: 11962509 |
Ref: Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. PMID: 11891321 Ref: Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. PMID: 12084458 |
Ref: Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats. PMID: 12664136 Ref: Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil. PMID: 12691609 Ref: mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. PMID: 12813132 Ref: Anticancer antifolates: current status and future directions. PMID: 14529544 |
Ref: Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA. PMID: 14664697 |
Ref: Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. PMID: 15814641 Ref: Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells. PMID: 16007155 |
Ref: Tumor quantification of several fluoropyrimidines resistance gene expression with a unique quantitative RT-PCR method. Implications for pretherapeutic determination of tumor resistance phenotype. PMID: 16387426 |
Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 Ref: Effects of folate cycle disruption by the green tea polyphenol epigallocatechin-3-gallate. PMID: 17683969 |
Ref: Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer. PMID: 18607850 Ref: Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. PMID: 18694510 Ref: miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. PMID: 19088023 |
Ref: TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. PMID: 19152710 Ref: Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells. PMID: 19190117 Ref: Antitumor therapy based on cellular competition. PMID: 19281300 Ref: MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism. PMID: 20041160 Ref: Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. PMID: 20049736 |
Ref: Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. PMID: 20020129 Ref: Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. PMID: 20433742 Ref: A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. PMID: 20615890 |
Ref: Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer. PMID: 21438757 |
Ref: Functional polymorphisms of folate metabolism and response to chemotherapy for colorectal cancer, a systematic review and meta-analysis. PMID: 22388795 |
Ref: Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk. PMID: 22961839 Ref: Analysis of the mRNA expression of chemotherapy-related genes in colorectal carcinoma using the danenberg tumor profile method. PMID: 23577026 |
Ref: A novel antibiotic-delivery system by using ovotransferrin as targeting molecule. PMID: 25315410 Ref: Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells. PMID: 25537274 Ref: Synthesis, spectroscopic properties, molecular docking, anti-colon cancer and anti-microbial studies of some novel metal complexes for 2-amino-4-phenylthiazole derivative. PMID: 25796013 Ref: Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study. PMID: 26108676 Ref: Simultaneous Analysis of SEPT9 Promoter Methylation Status, Micronuclei Frequency, and Folate-Related Gene Polymorphisms: The Potential for a Novel Blood-Based Colorectal Cancer Biomarker. PMID: 26633373 Ref: Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker. PMID: 26674922 Ref: Gene-Nutrient Interaction between Folate and Dihydrofolate Reductase in Risk for Adenomatous Polyp Occurrence: A Preliminary Report. PMID: 26875486 |
Ref: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis. PMID: 26676887 Ref: Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2'-Deoxyuridine in Colorectal Cancer Cell Lines. PMID: 27685866 |
Ref: Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells. PMID: 27187663 Ref: One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PMID: 28968444 |
Ref: Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups. PMID: 29462916 Ref: The association of polymorphisms in folate-metabolizing genes with response to adjuvant chemotherapy of colorectal cancer. PMID: 29845393 Ref: Personalized Nutrition-Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families. PMID: 29925788 Ref: Gene-Metabolite Interaction in the One Carbon Metabolism Pathway: Predictors of Colorectal Cancer in Multi-Ethnic Families. PMID: 30082654 Ref: Early disease relapse in a patient with colorectal cancer who harbors genetic variants of DPYD, TYMS, MTHFR and DHFR after treatment with 5-fluorouracil-based chemotherapy. PMID: 30207288 Ref: Synthesis, cytotoxicity, antimicrobial and docking simulation of novel pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[3,4-c]pyrimidine derivatives. PMID: 30332953 |