Primary Site >> Pancreatic Cancer
Gene >> DCLK1
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Ref: Exome sequencing and digital PCR analyses reveal novel mutated genes related to the metastasis of pancreatic ductal adenocarcinoma. PMID: 22797009 |
Ref: DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. PMID: 24040120 |
Ref: DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer. PMID: 24096005 Ref: XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. PMID: 24880079 Ref: Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. PMID: 24885928 |
Ref: DCLK1 is detectable in plasma of patients with Barrett's esophagus and esophageal adenocarcinoma. PMID: 25283374 Ref: Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells. PMID: 25723399 Ref: Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. PMID: 25906749 Ref: New insights into pancreatic cancer stem cells. PMID: 25914762 Ref: Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells. PMID: 26317547 Ref: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. PMID: 26366338 Ref: Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications. PMID: 26447334 |
Ref: Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells. PMID: 26673007 Ref: Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis. PMID: 26764906 Ref: Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis. PMID: 27058937 Ref: Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase. PMID: 27287716 Ref: Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure-activity relationship. PMID: 27503685 |
Ref: Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells. PMID: 28244691 Ref: Population Pharmacokinetics of Gemcitabine and dFdU in Pancreatic Cancer Patients Using an Optimal Design, Sparse Sampling Approach. PMID: 28346313 Ref: Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma. PMID: 28883702 Ref: Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells. PMID: 29048622 Ref: MicroRNA-195 Suppresses the Progression of Pancreatic Cancer by Targeting DCLK1. PMID: 29224010 Ref: Expression and prognostic significance of doublecortin-like kinase 1 in patients with hepatocellular carcinoma. PMID: 29344199 |
Ref: Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. PMID: 29604293 |