Primary Site >> Colorectal Cancer
Gene >> CYP3A4
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Ref: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. PMID: 8632764 Ref: P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. PMID: 8633005 |
Ref: Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3. PMID: 9145912 Ref: The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. PMID: 9202751 |
Ref: Metabolism of irinotecan (CPT-11) by human hepatic microsomes: participation of cytochrome P-450 3A and drug interactions. PMID: 9458091 Ref: Biosynthesis of an aminopiperidino metabolite of irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by human hepatic microsomes. PMID: 9698291 |
Ref: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. PMID: 10086330 |
Ref: Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. PMID: 10631627 Ref: N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. PMID: 10755318 Ref: Sulfotransferases in a human colon carcinoma cell line, Caco-2. PMID: 10919357 Ref: Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells. PMID: 10993481 Ref: DX-8951f: summary of phase I clinical trials. PMID: 11193901 |
Ref: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. PMID: 11297522 Ref: Hepatic extraction, metabolism, and biliary excretion of irinotecan in the isolated perfused rat liver. PMID: 11357175 Ref: Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. PMID: 11587480 |
Ref: Vitamin D receptor as an intestinal bile acid sensor. PMID: 12016314 Ref: Modulation of irinotecan metabolism by ketoconazole. PMID: 12118026 Ref: Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy. PMID: 12237780 Ref: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. PMID: 12244568 Ref: Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells. PMID: 12419308 Ref: Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. PMID: 12470639 |
Ref: Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines. PMID: 12625868 Ref: Gene expression profiles of ABC transporters and cytochrome P450 3A in Caco-2 and human colorectal cancer cell lines. PMID: 12636175 Ref: Induction of CYP3A4 by 1alpha,25-dyhydroxyvitamin D3 in HepG2 cells. PMID: 12738030 Ref: Role of c-Myc in nitric oxide-mediated suppression of cytochrome P450 3A4. PMID: 14575816 Ref: Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells. PMID: 14615069 |
Ref: A Mathematical simulation to explain the coordinated functions of efflux and metabolism limiting the transport of anti-HIV agents across Caco-2 cells. PMID: 14999363 Ref: C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression. PMID: 15205382 Ref: Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor. PMID: 15258100 Ref: Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene. PMID: 15358113 Ref: Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes. PMID: 15523087 |
Ref: Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. PMID: 15578590 Ref: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. PMID: 15655543 Ref: Pharmacogenomics of fluorouracil, irinotecan, and oxaliplatin in hepatic metastases of colorectal cancer: clinical implications. PMID: 15727486 Ref: P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing. PMID: 15856231 Ref: Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis. PMID: 15897573 Ref: Promoter-, cell-, and ligand-specific transactivation responses of the VDRB1 isoform. PMID: 15992766 Ref: A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. PMID: 16006997 Ref: [Network for the collection and distribution of Japanese liver tissues resected surgically for drug development and research use]. PMID: 16541756 Ref: Caco-2 cell permeability assays to measure drug absorption. PMID: 16922635 |
Ref: Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. PMID: 16678547 Ref: Acquired resistance to the anticancer drug paclitaxel is associated with induction of cytochrome P450 2C8. PMID: 16753005 Ref: Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression? PMID: 16755466 Ref: Strategies to enhance epidermal growth factor inhibition: targeting the mevalonate pathway. PMID: 16857822 Ref: Clinical pharmacokinetics of irinotecan-based chemotherapy in colorectal cancer patients. PMID: 18666754 |
Ref: Effects of herbal medicinal products and food supplements on induction of CYP1A2, CYP3A4 and MDR1 in the human colon carcinoma cell line LS180. PMID: 17163579 Ref: Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. PMID: 17262809 Ref: In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato. PMID: 17336049 Ref: Identification of NR1I2 genetic variation using resequencing. PMID: 17404718 Ref: Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients. PMID: 17605821 Ref: Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. PMID: 17615053 Ref: Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose. PMID: 17638912 |
Ref: Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity. PMID: 17851638 Ref: Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells. PMID: 18299335 Ref: Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. PMID: 18385293 Ref: Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients. PMID: 18797458 Ref: Drug interactions between chemotherapeutic regimens and antiepileptics. PMID: 18803983 |
Ref: PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. PMID: 19138736 |
Ref: Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. PMID: 20153625 |
Ref: Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. PMID: 21317201 Ref: Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. PMID: 21342487 Ref: Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. PMID: 21490239 Ref: Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells. PMID: 21733184 Ref: [Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro]. PMID: 21734321 Ref: Overexpression of CYP3A4 in a COLO 205 Colon Cancer Stem Cell Model in vitro. PMID: 24212669 |
Ref: Cytotoxic and potent CYP1 inhibitors from the marine algae Cymopolia barbata. PMID: 22686946 Ref: Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer. PMID: 23631285 |
Ref: Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis. PMID: 23597015 Ref: Phase I safety, pharmacokinetic and pharmacodynamic evaluation of the vascular disrupting agent ombrabulin (AVE8062) in patients with advanced solid tumors. PMID: 23833302 |
Ref: Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans. PMID: 24562971 Ref: Tissue-specific regulation of pregnane X receptor in cancer development and therapy. PMID: 24690092 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells. PMID: 25364403 |
Ref: Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells. PMID: 27261575 Ref: Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism. PMID: 27458137 |
Ref: Clarithromycin co-administration does not increase irinotecan (CPT-11) toxicity in colorectal cancer patients. PMID: 28711984 Ref: Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations. PMID: 28919712 |
Ref: The burgeoning role of cytochrome P450-mediated vitamin D metabolites against colorectal cancer. PMID: 29719203 |