Primary Site >> Liver Cancer
Gene >> CYP2E1
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Ref: Cytochrome P450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma. PMID: 7557094 Ref: Cytochrome P4502E1 (CYP2E1) genetic polymorphism in a case-control study of gastric cancer and liver disease. PMID: 7581484 |
Ref: trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines. PMID: 8681951 Ref: RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma. PMID: 8977352 |
Ref: Lack of association of cytochrome P450 2E1 genetic polymorphisms with the risk of human hepatocellular carcinoma. PMID: 9180139 Ref: Interaction between dose and susceptibility to environmental cancer: a short review. PMID: 9255556 |
Ref: Differential expression of cytochrome P4502E1 (CYP2E1) in Morris hepatomas and livers of tumor bearing rats. PMID: 9538127 |
Ref: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. PMID: 10086330 |
Ref: [Progress in researches on the relationship between genetic polymorphisms of alcohol-metabolizing enzymes and cancers]. PMID: 11172647 Ref: Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. PMID: 11268819 Ref: The ubiquitin-proteasome 26s pathway in liver cell protein turnover: effect of ethanol and drugs. PMID: 11391075 |
Ref: Assessment of frequencies of lifestyle factors and polymorphisms of drug-metabolizing enzymes (NAT2, CYP2E1) in human hepatocellular carcinoma (HCC) patients in a department of surgical medicine--a pilot investigation. PMID: 11911601 Ref: Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. PMID: 12060674 Ref: Immunohistochemical study of CYP2E1 in hepatocellular carcinoma carcinogenesis: examination with newly prepared anti-human CYP2E1 antibody. PMID: 12068315 Ref: Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci. PMID: 12143053 |
Ref: CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer. PMID: 12569554 Ref: Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. PMID: 12604681 Ref: Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma. PMID: 12759747 Ref: Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. PMID: 12940444 Ref: Role of iron in alcoholic liver disease: introduction and summary of the symposium. PMID: 12957291 Ref: Antituberculosis drug-induced hepatitis: risk factors, prevention and management. PMID: 15332488 |
Ref: Cytochrome P450 gene polymorphism and cancer. PMID: 15180491 Ref: Cytochrome P450 and liver diseases. PMID: 15180496 Ref: Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma. PMID: 15239125 |
Ref: A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors. PMID: 15471898 Ref: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. PMID: 15661146 Ref: Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma. PMID: 16077914 Ref: Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold. PMID: 16271068 Ref: Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells. PMID: 16324217 |
Ref: High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. PMID: 16624332 Ref: Identification of CYP2C9*2 allele in HepG2 cell line. PMID: 17827526 |
Ref: Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage. PMID: 16963249 Ref: Postulated carbon tetrachloride mode of action: a review. PMID: 17763046 Ref: Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo. PMID: 18056438 |
Ref: Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. PMID: 17983700 Ref: Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity. PMID: 18497573 Ref: Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. PMID: 18589557 |
Ref: Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. PMID: 19489076 Ref: [Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome P450 2E1 gene in Zhuang population, Guangxi]. PMID: 19565876 Ref: Alcoholic liver disease and hepatitis C: a frequently underestimated combination. PMID: 19630099 Ref: Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population. PMID: 19643819 Ref: Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. PMID: 19794959 |
Ref: Mode of action considerations in the quantitative assessment of tumour responses in the liver. PMID: 20030633 Ref: Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. PMID: 20100738 Ref: [Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]. PMID: 20364586 Ref: Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. PMID: 20404016 Ref: Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. PMID: 20813101 |
Ref: An in vitro comparative study with furyl-1,4-quinones endowed with anticancer activities. PMID: 20237828 Ref: Alcohol induces liver neoplasia in a novel alcohol-preferring rat model. PMID: 21790668 |
Ref: CYP2E1 PstI/RsaI polymorphism and interaction with alcohol consumption in hepatocellular carcinoma susceptibility: evidence from 1,661 cases and 2,317 controls. PMID: 22249978 Ref: Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: a genotype-phenotype study in cancers associated with drinking and/or smoking. PMID: 22614694 Ref: CYP2E1 RsaI/PstI polymorphism and liver cancer risk among east Asians: a HuGE review and meta-analysis. PMID: 23244081 |
Ref: Diet-induced obesity and ethanol impair progression of hepatocellular carcinoma in a mouse mesenteric vein injection model. PMID: 22806512 Ref: Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. PMID: 23454624 Ref: Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells. PMID: 23824954 Ref: Pharmacological blockage of CYP2E1 and alcohol-mediated liver cancer: is the time ready? PMID: 23825901 Ref: Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. PMID: 24066058 Ref: Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples. PMID: 24278187 |
Ref: Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury. PMID: 24318994 Ref: Curcumin and (-)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells. PMID: 24508477 Ref: Alcohol induced hepatic degeneration in a hepatitis C virus core protein transgenic mouse model. PMID: 24608925 Ref: [Mechanism and clinical significance of HBx-mediated inhibition of CYP2E1 expression in the human HepG2 hepatoma cell line]. PMID: 24735595 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. PMID: 25024626 Ref: Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress. PMID: 25056785 Ref: Cytochrome P450 2E1 gene polymorphism and alcohol drinking on the risk of hepatocellular carcinoma: a meta-analysis. PMID: 25185993 Ref: HBx inhibits CYP2E1 gene expression via downregulating HNF4alpha in human hepatoma cells. PMID: 25238230 |
Ref: Copy number variability analysis of pharmacogenes in patients with lymphoma, leukemia, hepatocellular, and lung carcinoma using The Cancer Genome Atlas data. PMID: 25379720 Ref: The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC). PMID: 25427918 Ref: Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. PMID: 25592162 Ref: N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer. PMID: 25601990 Ref: The effect of CYP, GST, and SULT polymorphisms and their interaction with smoking on the risk of hepatocellular carcinoma. PMID: 25654087 Ref: Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice. PMID: 25922528 Ref: The generation of carcinogenic etheno-DNA adducts in the liver of patients with nonalcoholic fatty liver disease. PMID: 26005678 Ref: Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis. PMID: 26163595 Ref: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. PMID: 26233904 Ref: Detection of carcinogenic etheno-DNA adducts in children and adolescents with non-alcoholic steatohepatitis (NASH). PMID: 26734629 |
Ref: Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach. PMID: 27086920 Ref: Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. PMID: 27116542 Ref: Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease. PMID: 27122661 Ref: Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma. PMID: 27203676 Ref: Integrated Multiple "-omics" Data Reveal Subtypes of Hepatocellular Carcinoma. PMID: 27806083 |
Ref: Meta-analysis of CYP2E1 polymorphisms in liver carcinogenesis. PMID: 27637154 Ref: Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans. PMID: 28253196 Ref: Altered cellular metabolism of HepG2 cells caused by microcystin-LR. PMID: 28336091 Ref: Cytochrome P450 2E1 increases the sensitivity of hepatoma cells to vitamin K2. PMID: 28339022 Ref: Mice lacking liver-specific beta-catenin develop steatohepatitis and fibrosis after iron overload. PMID: 28341391 Ref: A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae. PMID: 28956809 Ref: High CYP2E1 activity correlates with hepatofibrogenesis induced by nitrosamines. PMID: 29348818 |
Ref: Higher CYP2E1 Activity Correlates with Hepatocarcinogenesis Induced by Diethylnitrosamine. PMID: 29467309 Ref: Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine. PMID: 29722557 Ref: Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population. PMID: 29765251 Ref: From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. PMID: 29917271 Ref: Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line. PMID: 29984664 Ref: Black Radish (Raphanus sativus L. var. niger) Extract Mediates Its Hepatoprotective Effect on Carbon Tetrachloride-Induced Hepatic Injury by Attenuating Oxidative Stress. PMID: 30067118 Ref: Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma. PMID: 30148168 Ref: STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice. PMID: 30377054 |