Primary Site >> Liver Cancer
Gene >> CYP1A2
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Ref: Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. PMID: 2206399 |
Ref: Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. PMID: 1657755 |
Ref: Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). PMID: 7614688 |
Ref: trans-Acting factors, detoxication enzymes and hepatitis B virus replication in a novel set of human hepatoma cell lines. PMID: 8681951 Ref: 2-Acetylaminofluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation. PMID: 8910950 |
Ref: Metabolism of food-derived heterocyclic amines in nonhuman primates. PMID: 9202757 Ref: Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. PMID: 9230270 Ref: Distinct time courses of increase in cytochromes P450 1A2, 2A5 and glutathione S-transferases during the progressive hepatitis associated with Helicobacter hepaticus. PMID: 9395219 |
Ref: The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure. PMID: 9539029 |
Ref: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. PMID: 10086330 Ref: CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. PMID: 10469630 Ref: Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. PMID: 10496959 |
Ref: Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. PMID: 11064004 Ref: DX-8951f: summary of phase I clinical trials. PMID: 11193901 |
Ref: Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2. PMID: 11470995 |
Ref: Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies. PMID: 11908637 Ref: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. PMID: 12107646 Ref: Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone. PMID: 12147246 Ref: Induction of P-glycoprotein, glutathione-S-transferase and cytochrome P450 in rat liver by atrazine. PMID: 21782617 |
Ref: CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer. PMID: 12569554 |
Ref: Cytochrome P450 gene polymorphism and cancer. PMID: 15180491 |
Ref: Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma. PMID: 16048566 |
Ref: Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. PMID: 16204462 Ref: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). PMID: 17160104 Ref: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). PMID: 17342196 |
Ref: The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. PMID: 17241619 |
Ref: Antigenotoxic effect of Xanthohumol in rat liver slices. PMID: 17981005 Ref: Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. PMID: 17983700 Ref: The effect of transcatheter arterial chemoembolization on CYP1A2 activity in patients with hepatocellular carcinoma. PMID: 18834363 |
Ref: Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. PMID: 19376845 Ref: Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population. PMID: 19643819 Ref: The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. PMID: 21784029 |
Ref: The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice. PMID: 20118626 Ref: Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies). PMID: 21383778 Ref: Tumorigenesis of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), but not enhancing effects of concomitant high-fat diet, on lung carcinogenesis in female A/J mice. PMID: 22966271 |
Ref: Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice. PMID: 20473876 Ref: Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice. PMID: 21147764 Ref: Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine. PMID: 21396975 Ref: Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. PMID: 21607682 Ref: Oxidative stress pathways in noncancerous human liver tissue to predict hepatocellular carcinoma recurrence: a prospective, multicenter study. PMID: 22006857 Ref: Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold. PMID: 22008537 |
Ref: Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis. PMID: 22291063 Ref: Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates. PMID: 22447115 Ref: Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver. PMID: 22508569 Ref: Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1). PMID: 22640941 Ref: Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action. PMID: 22687989 Ref: Threshold dose of liver tumor promoting effect of beta-naphthoflavone in rats. PMID: 22687991 Ref: Genetic polymorphism of drug metabolizing enzymes in association with risk of bile duct cancer. PMID: 23480767 |
Ref: Inhibition of hepatocyte nuclear factor 1 and 4 alpha (HNF1alpha and HNF4alpha) as a mechanism of arsenic carcinogenesis. PMID: 23052196 |
Ref: Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes. PMID: 24157377 Ref: In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential. PMID: 24405273 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. PMID: 25024626 |
Ref: A novel effect of parylene-based surface coating on HepG2 cell function. PMID: 25491976 Ref: N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer. PMID: 25601990 Ref: Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice. PMID: 25922528 Ref: Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. PMID: 26187448 Ref: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. PMID: 26233904 Ref: Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients. PMID: 26516155 Ref: Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice. PMID: 26589287 Ref: CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures. PMID: 26643992 |
Ref: Root extract of water dropwort, Oenanthe javanica (Blume) DC, induces protein and gene expression of phase I carcinogen-metabolizing enzymes in HepG2 cells. PMID: 27069833 Ref: Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach. PMID: 27086920 Ref: Cytochrome P450 1A2 Metabolizes 17beta-Estradiol to Suppress Hepatocellular Carcinoma. PMID: 27093553 Ref: Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma. PMID: 27203676 |
Ref: Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells. PMID: 28245756 Ref: Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. PMID: 28256105 Ref: Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes. PMID: 28279696 Ref: Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice. PMID: 28535182 Ref: Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib. PMID: 28915658 Ref: Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. PMID: 28963435 |
Ref: Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole. PMID: 29082813 Ref: Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma. PMID: 30148168 Ref: Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4gamma. PMID: 30224520 |