Primary Site >> Pancreatic Cancer
Gene >> CXCR4
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Ref: Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. PMID: 10999740 |
Ref: Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. PMID: 12761880 |
Ref: CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. PMID: 14749473 Ref: [mRNA expression of chemokine receptors in hepatic and pancreatic tumor cell lines]. PMID: 15332556 Ref: Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. PMID: 15548713 |
Ref: The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer. PMID: 15662133 Ref: Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma. PMID: 15978329 Ref: CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. PMID: 16230077 Ref: The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. PMID: 16300475 |
Ref: Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma. PMID: 16752411 Ref: Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. PMID: 17012836 Ref: Strong expression of chemokine receptor CXCR4 by pancreatic cancer correlates with advanced disease. PMID: 17089032 Ref: Characterization of the CXCR4 signaling in pancreatic cancer cells. PMID: 18175225 |
Ref: Beta-catenin is a promising key factor in the SDF-1/CXCR4 axis on metastasis of pancreatic cancer. PMID: 17379424 Ref: Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells. PMID: 17560257 Ref: Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. PMID: 18371365 |
Ref: CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer. PMID: 18349830 Ref: The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia. PMID: 18664506 Ref: Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer. PMID: 18791122 Ref: Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. PMID: 18974138 Ref: Blockade of SDF-1/CXCR4 signalling inhibits pancreatic cancer progression in vitro via inactivation of canonical Wnt pathway. PMID: 19002187 |
Ref: CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. PMID: 19035451 Ref: Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. PMID: 19064997 Ref: [Expression of CXCL12-CXCR4 and its association with angiogenesis in pancreatic cancer]. PMID: 19615285 |
Ref: PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. PMID: 19784070 Ref: Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways. PMID: 19820417 Ref: Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B. PMID: 19932585 Ref: Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. PMID: 20043076 Ref: Pancreatic stellate cells increase the invasion of human pancreatic cancer cells through the stromal cell-derived factor-1/CXCR4 axis. PMID: 20484957 Ref: Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells. PMID: 20564084 Ref: Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors. PMID: 20631070 Ref: Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-kappaB activation in breast and pancreatic tumor cells. PMID: 20699088 Ref: The molecular mechanisms of traditional Chinese medicine ZHENG syndromes on pancreatic tumor growth. PMID: 20702498 Ref: High levels of expression of human stromal cell-derived factor-1 are associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. PMID: 20732965 Ref: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. PMID: 20798912 Ref: {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. PMID: 20864511 Ref: CXCL12-CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. PMID: 21045835 |
Ref: Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells. PMID: 20426768 Ref: The CXCR4-CXCL12 pathway facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis. PMID: 20462600 Ref: Acetyl-11-keto-beta-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression. PMID: 21448932 Ref: Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1alpha-dependent manner in pancreatic cancer cells. PMID: 21778785 Ref: Holoclone forming cells from pancreatic cancer cells enrich tumor initiating cells and represent a novel model for study of cancer stem cells. PMID: 21826251 Ref: Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets. PMID: 22066019 Ref: Molecular pathogenesis of pancreatic cancer and clinical perspectives. PMID: 22116519 Ref: Epigenetic changes of CXCR4 and its ligand CXCL12 as prognostic factors for sporadic breast cancer. PMID: 22220212 Ref: Treatment of pancreatic cancer: what can we really predict today? PMID: 24212636 |
Ref: Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. PMID: 21935918 Ref: Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. PMID: 22294553 Ref: Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells. PMID: 22319600 Ref: SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway. PMID: 22450749 Ref: Molecular profiling of pancreatic neuroendocrine tumors in sporadic and Von Hippel-Lindau patients. PMID: 22461457 Ref: Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells. PMID: 22472349 Ref: Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells. PMID: 22626610 Ref: Nestin and other putative cancer stem cell markers in pancreatic cancer. PMID: 22718289 Ref: Virotherapy using a novel chimeric oncolytic adenovirus prolongs survival in a human pancreatic cancer xenograft model. PMID: 22853858 Ref: Pancreatic carcinoma cell lines reflect frequency and variability of cancer stem cell markers in clinical tissue. PMID: 22948659 Ref: Stromal cell-derived factor 1alpha mediates resistance to mTOR-directed therapy in pancreatic cancer. PMID: 22952422 Ref: Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells. PMID: 22963768 Ref: CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB: implications for bidirectional tumor-stromal interactions. PMID: 22995914 Ref: Anti-CXCR4 monoclonal antibody conjugated to ultrasmall superparamagnetic iron oxide nanoparticles in an application of MR molecular imaging of pancreatic cancer cell lines. PMID: 23012484 Ref: CXCL12/CXCR4 axis plays pivotal roles in the organ-specific metastasis of pancreatic adenocarcinoma: A clinical study. PMID: 23181100 Ref: MSH2 and CXCR4 involvement in malignant VIPoma. PMID: 23231927 |
Ref: Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability. PMID: 22907431 Ref: BRCA2 dysfunction promotes malignant transformation of pancreatic intraepithelial neoplasia. PMID: 22934697 Ref: Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. PMID: 23338123 Ref: Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells. PMID: 23338841 Ref: Towards a tailored therapy in pancreatic cancer. PMID: 23650783 Ref: An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer. PMID: 23672538 Ref: SDF-1alpha upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines. PMID: 23712777 Ref: An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor kappaB- and hypoxia-inducible factor 1alpha-mediated up-regulation of CXCR4. PMID: 23740244 Ref: A bioengineered metastatic pancreatic tumor model for mechanistic investigation of chemotherapeutic drugs. PMID: 23747489 Ref: Cancer stem cell in the progression and therapy of pancreatic cancer. PMID: 23747847 Ref: Drug-eluting scaffold to deliver chemotherapeutic medication for management of pancreatic cancer after surgery. PMID: 23885173 Ref: Aberrant expression of CXCR4 and beta-catenin in pancreatic cancer. PMID: 24023356 Ref: Role of CXCL12/CXCR4 signaling axis in pancreatic cancer. PMID: 24033967 Ref: Adipose tissue-derived stem cells promote pancreatic cancer cell proliferation and invasion. PMID: 24068191 Ref: Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes. PMID: 24069258 Ref: CXCL12-CXCR4 promotes proliferation and invasion of pancreatic cancer cells. PMID: 24175834 Ref: [Regulation effect of adipose-derived mesenchymal stem cells on pancreatic cancer cells]. PMID: 24330967 |
Ref: Hypoxia-independent gene expression mediated by SOX9 promotes aggressive pancreatic tumor biology. PMID: 24302456 Ref: CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PMID: 24594697 Ref: Analysis of dysregulation of immune system in pancreatic cancer based on gene expression profile. PMID: 24619357 Ref: Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. PMID: 24785258 Ref: Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4. PMID: 24840182 Ref: Study on the relationship between CXCR4 expression and perineural invasion in pancreatic cancer. PMID: 24998559 Ref: Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy. PMID: 25240521 Ref: Nuclear receptors in pancreatic tumor cells. PMID: 25503115 Ref: A concise review on the current understanding of pancreatic cancer stem cells. PMID: 26451384 |
Ref: CXCR4 promotes GSK3beta expression in pancreatic cancer cells via the Akt pathway. PMID: 25145299 Ref: Targeting cancer stem cells in solid tumors by vitamin D. PMID: 25460302 Ref: Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway. PMID: 25557170 Ref: Stromal-derived factor-1alpha/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer. PMID: 25605248 Ref: Paracrine SDF-1alpha signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells. PMID: 25609203 Ref: CXCR4 over-expression and survival in cancer: a system review and meta-analysis. PMID: 25669980 Ref: Exosomal lipids induce human pancreatic tumoral MiaPaCa-2 cells resistance through the CXCR4-SDF-1alpha signaling axis. PMID: 25821841 Ref: Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. PMID: 25826687 Ref: The chemokine receptors CXCR4/CXCR7 and their primary heterodimeric ligands CXCL12 and CXCL12/high mobility group box 1 in pancreatic cancer growth and development: finding flow. PMID: 25872129 Ref: Orthotopic inflammation-related pancreatic carcinogenesis in a wild-type mouse induced by combined application of caerulein and dimethylbenzanthracene. PMID: 25916208 Ref: Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications. PMID: 25970774 Ref: Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells. PMID: 26010611 Ref: Application of chemokine receptor antagonist with stents reduces local inflammation and suppresses cancer growth. PMID: 26044561 Ref: CXCR4--A Prognostic and Clinicopathological Biomarker for Pancreatic Ductal Adenocarcinoma: A Meta-Analysis. PMID: 26091099 Ref: GSK3beta mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway. PMID: 26213494 Ref: Hypoxia promotes C-X-C chemokine receptor type 4 expression through microRNA-150 in pancreatic cancer cells. PMID: 26622579 |
Ref: First Experience with Chemokine Receptor CXCR4-Targeted PET Imaging of Patients with Solid Cancers. PMID: 26769866 Ref: Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists. PMID: 27175473 Ref: Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis. PMID: 27267632 Ref: The utility of hyperthermic intra-abdominal chemotherapy with gemcitabine for the inhibition of tumor progression in an experimental model of pancreatic peritoneal carcinomatosis, in relation to their behavior with pancreatic cancer stem cells CD133+ CXCR PMID: 27289344 Ref: Pancreatic cancer stem cell markers and exosomes - the incentive push. PMID: 27468191 Ref: Antitumor effects of herbal mixture extract in the pancreatic adenocarcinoma cell line PANC1. PMID: 27599899 Ref: Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. PMID: 27609457 Ref: Radiation promotes epithelial-to-mesenchymal transition and invasion of pancreatic cancer cell by activating carcinoma-associated fibroblasts. PMID: 27822411 Ref: Local and transient gene expression primes the liver to resist cancer metastasis. PMID: 27831902 |
Ref: Hormophysa triquerta polyphenol, an elixir that deters CXCR4- and COX2-dependent dissemination destiny of treatment-resistant pancreatic cancer cells. PMID: 27974694 Ref: Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells. PMID: 27986950 Ref: Galectin-1-driven upregulation of SDF-1 in pancreatic stellate cells promotes pancreatic cancer metastasis. PMID: 28336327 Ref: Protocol of the PANCALYZE trial: a multicenter, prospective study investigating the tumor biomarkers CXCR4, SMAD4, SOX9 and IFIT3 in patients with resected pancreatic adenocarcinoma to predict the pattern of recurrence of the disease. PMID: 28356064 Ref: Integrated clinicopathological features and gene microarray analysis of pancreatic neuroendocrine tumors. PMID: 28479381 Ref: Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy. PMID: 28549596 Ref: KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the Kras(G12D) p53(flox/flox) model. PMID: 28581520 Ref: The pancreatic cancer microenvironment: A true double agent. PMID: 28605029 Ref: Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice. PMID: 28881737 Ref: CXCR4/Let-7a Axis Regulates Metastasis and Chemoresistance of Pancreatic Cancer Cells Through Targeting HMGA2. PMID: 28954272 Ref: Identification of molecular mechanisms of glutamine in pancreatic cancer. PMID: 29163679 |
Ref: NFkappaB-Mediated Invasiveness in CD133(+) Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling. PMID: 28970361 Ref: Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery. PMID: 29187403 Ref: Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer. PMID: 29434873 Ref: Artemin regulates CXCR4 expression to induce migration and invasion in pancreatic cancer cells through activation of NF-kappaB signaling. PMID: 29453972 Ref: Simvastatin inhibits sonic hedgehog signaling and stemness features of pancreatic cancer. PMID: 29627496 Ref: Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer. PMID: 30337520 |