Primary Site >> Colorectal Cancer
Gene >> CXCL12
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Ref: Reduced expression of the CXC chemokine hIRH/SDF-1alpha mRNA in hepatoma and digestive tract cancer. PMID: 9398042 |
Ref: The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. PMID: 12839981 |
Ref: Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells. PMID: 15592929 Ref: Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. PMID: 15837989 Ref: CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. PMID: 16125170 |
Ref: Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers. PMID: 16380080 Ref: Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. PMID: 16568088 Ref: Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth. PMID: 16585175 Ref: Involvement of chemokine receptor CCR6 in colorectal cancer metastasis. PMID: 16641550 Ref: Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients. PMID: 16675573 Ref: Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome. PMID: 16794396 Ref: Adenosine upregulates CXCR4 and enhances the proliferative and migratory responses of human carcinoma cells to CXCL12/SDF-1alpha. PMID: 16823836 Ref: Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases. PMID: 17075975 |
Ref: Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells. PMID: 17053212 Ref: Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. PMID: 17130833 Ref: Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients. PMID: 17143542 Ref: Identification of gene signatures for invasive colorectal tumor cells. PMID: 17936523 Ref: Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer. PMID: 17982648 |
Ref: Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. PMID: 18351386 Ref: Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro. PMID: 18416455 Ref: [Role of vascular endothelial growth factor receptor 1-positive hematopoietic progenitor cell clusters in human colorectal carcinoma metastasis]. PMID: 18504182 Ref: Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells. PMID: 18558091 Ref: Expression profiling of angiogenic genes for the characterisation of colorectal carcinoma. PMID: 18656346 Ref: [Expression of chemokine receptor CXCR4 in colorectal carcinoma and its relationship with clinicopathological parameters]. PMID: 18803056 |
Ref: Expression and function of T cell homing molecules in Hodgkin's lymphoma. PMID: 18488221 Ref: A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration. PMID: 19305148 Ref: [Effect of stromal cell-derived factor-1 and its receptor CXCR4 on liver metastasis of human colon cancer]. PMID: 19563077 Ref: CXCR4 regulates the early extravasation of metastatic tumor cells in vivo. PMID: 19568410 Ref: Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis. PMID: 19588204 Ref: Prognostic significance of CXCL12 expression in patients with colorectal carcinoma. PMID: 19605814 Ref: CXCL12, CXCR4 and CXCR7 expression in brain metastases. PMID: 19625779 Ref: The role of vascular CXCR4 expression in colorectal carcinoma. PMID: 19912363 Ref: [Shikonin down-regulates CXCR4 expression and inhibits CXCL12-induced migratory responses in colorectal carcinoma cell line SW480]. PMID: 19921580 |
Ref: CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. PMID: 19821487 Ref: Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer. PMID: 20122155 Ref: Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy. PMID: 20177796 Ref: Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer. PMID: 20334899 Ref: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor. PMID: 20798912 Ref: CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis. PMID: 20877573 Ref: Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12. PMID: 20946648 |
Ref: Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies. PMID: 20865359 Ref: Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy. PMID: 21240461 Ref: CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells. PMID: 21349176 Ref: Influence of CXCR4/SDF-1 axis on E-cadherin/beta-catenin complex expression in HT29 colon cancer cells. PMID: 21350711 Ref: Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. PMID: 21990345 Ref: Histopathological predictors of regional lymph node metastasis at the invasive front in early colorectal cancer. PMID: 22034887 Ref: Human Embryonic-like ECM (hECM) Stimulates Proliferation and Differentiation in Stem Cells While Killing Cancer Cells. PMID: 24298336 |
Ref: Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer. PMID: 21080209 Ref: Stromal cell-derived factor-1/CXC receptor 4 and beta1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells. PMID: 21567400 Ref: CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases. PMID: 21584832 Ref: Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1. PMID: 21977032 Ref: CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer. PMID: 22075627 Ref: Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor. PMID: 22172099 Ref: Will the Stroma-derived Factor-1alpha (CXCL12)/CXCR4 Pathway Become a Major Concern for Advanced Colorectal Cancer? PMID: 22413073 Ref: NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling. PMID: 22503542 Ref: A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability. PMID: 22869557 Ref: CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. PMID: 22871210 Ref: Stromal cell-derived factor-1alpha and macrophage migration-inhibitory factor induce metastatic behavior in CXCR4-expressing colon cancer cells. PMID: 23023114 Ref: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1. PMID: 23098564 |
Ref: Visfatin induces stromal cell-derived factor-1 expression by beta1 integrin signaling in colorectal cancer cells. PMID: 23042611 Ref: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration. PMID: 23192271 Ref: SDF-1alpha G801A polymorphism in Southern Iranian patients with colorectal and gastric cancers. PMID: 23242967 Ref: Clinical applications of gene expression in colorectal cancer. PMID: 23730510 Ref: CXCL12-G801A polymorphism modulates risk of colorectal cancer in Taiwan. PMID: 24482642 |
Ref: SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6. PMID: 24085800 Ref: The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1alpha-induced gene expression, invasion and chemosensitivity of colon cancer. PMID: 24255072 Ref: A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients. PMID: 24375277 Ref: Interaction of the chemokines I-TAC (CXCL11) and SDF-1 (CXCL12) in the regulation of tumor angiogenesis of colorectal cancer. PMID: 24493023 Ref: Combined morphologic and molecular classification for predicting lymph node metastasis in early-stage colorectal adenocarcinoma. PMID: 24562932 Ref: Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. PMID: 24629239 Ref: Biomarker-based treatment selection in early-stage rectal cancer to promote organ preservation. PMID: 25052224 Ref: SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/beta-catenin signaling pathway. PMID: 25150783 Ref: Circulating biomarkers in advanced colorectal cancer patients randomly assigned to three bevacizumab-based regimens. PMID: 25256831 Ref: Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer. PMID: 25405996 |
Ref: Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer. PMID: 24825098 Ref: Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. PMID: 25131778 Ref: Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models. PMID: 25504752 Ref: CXCR4 and CXCL12 Expression in Rectal Tumors of Stage IV Patients Before and After Local Radiotherapy and Systemic Neoadjuvant Treatment. PMID: 25557636 Ref: Downregulation of the CXCR4/CXCL12 axis blocks the activation of the Wnt/beta-catenin pathway in human colon cancer cells. PMID: 25960214 Ref: The critical roles of tumor-initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis using a unique humanized orthotopic mouse model. PMID: 25962655 Ref: Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer. PMID: 26020117 Ref: Role of B7-H4 siRNA in Proliferation, Migration, and Invasion of LOVO Colorectal Carcinoma Cell Line. PMID: 26078947 Ref: [The metastatic niche. Mechanisms and prognostic implications]. PMID: 26395891 Ref: Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis. PMID: 26406413 Ref: Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26. PMID: 26552750 |
Ref: Functional diversity of stromal cell-derived factor 1 splice variants in colorectal cancer and melanoma. PMID: 26567118 Ref: The dipeptidyl peptidase-4 inhibitor sitagliptin suppresses mouse colon tumorigenesis in type 2 diabetic mice. PMID: 26573958 Ref: CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer. PMID: 26678887 Ref: Angiogenesis-Related Markers and Prognosis After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer. PMID: 26727921 Ref: Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation. PMID: 26744523 Ref: Modulation of chemokines in the tumor microenvironment enhances oncolytic virotherapy for colorectal cancer. PMID: 26956047 Ref: Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues. PMID: 26998092 Ref: Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4(+) colorectal cancer models. PMID: 27085904 Ref: Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists. PMID: 27571038 Ref: Identification of key pathways and genes in colorectal cancer using bioinformatics analysis. PMID: 27581154 Ref: Effect of colorectal cancer on the number of normal stem cells circulating in peripheral blood. PMID: 27779706 Ref: CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients. PMID: 28123896 |
Ref: LPS-induced CXCR4-dependent migratory properties and a mesenchymal-like phenotype of colorectal cancer cells. PMID: 26745593 Ref: Onbaekwon Suppresses Colon Cancer Cell Invasion by Inhibiting Expression of the CXC Chemokine Receptor 4. PMID: 27160279 Ref: ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer. PMID: 27489286 Ref: Activation of CXCL12/CXCR4 renders colorectal cancer cells less sensitive to radiotherapy via up-regulating the expression of survivin. PMID: 27798120 Ref: CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer. PMID: 28176874 Ref: Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. PMID: 28418886 Ref: Expression of CXCR-4 and IDO in human colorectal cancer: An immunohistochemical approach. PMID: 28515923 Ref: Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis. PMID: 28621237 Ref: The Axis of CXCR4/SDF-1 Plays a Role in Colon Cancer Cell Adhesion Through Regulation of the AKT and IGF1R Signalling Pathways. PMID: 28739729 Ref: The Allosteric Hemoglobin Effector ITPP Inhibits Metastatic Colon Cancer in Mice. PMID: 28742687 Ref: Fibroblast-derived CXCL12/SDF-1alpha promotes CXCL6 secretion and co-operatively enhances metastatic potential through the PI3K/Akt/mTOR pathway in colon cancer. PMID: 28811711 Ref: Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer. PMID: 28900008 Ref: Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer. PMID: 28936810 Ref: Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade. PMID: 28963140 |
Ref: The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. PMID: 29242607 Ref: CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer. PMID: 29305742 Ref: CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. PMID: 29436696 Ref: Gut microbiota modulate T cell trafficking into human colorectal cancer. PMID: 29437871 Ref: P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. PMID: 29454793 Ref: Expression Patterns of CXCL12 and its Receptor in Colorectal Carcinoma. PMID: 29739049 Ref: The CXCL12 rs1801157 polymorphism and risk of colorectal cancer: a meta-analysis. PMID: 29760554 Ref: Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer. PMID: 29887884 Ref: Profiles of alternative splicing in colorectal cancer and their clinical significance: A study based on large-scale sequencing data. PMID: 30243491 Ref: Integrin alphavbeta6 Plays an Bi-directional Regulation Role Between Colon Cancer cells and Cancer-Associated Fibroblasts. PMID: 30355650 |