Primary Site >> Pancreatic Cancer
Gene >> CTSB
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Ref: Cysteine proteinases and metastasis. PMID: 6093995 |
Ref: Variant cathepsin B activity secreted from human pancreatic cancer cell lines into protein-free chemically defined medium. PMID: 2606304 |
Ref: Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions. PMID: 8286198 Ref: Immunohistochemical study on cathepsin-B and cathepsin-d in pancreatic-cancer. PMID: 21607400 |
Ref: Intracellular degradation of the C-peptide of proinsulin, in a human insulinoma: identification of sites of cleavage and evidence for a role for cathepsin B. PMID: 7716141 |
Ref: The metastatic potential of human pancreatic cell lines in the liver of nude mice correlates well with cathepsin B activity. PMID: 15235133 |
Ref: Evaluation of cleavable (Tyr3)-octreotate derivatives for longer intracellular probe residence. PMID: 15149193 |
Ref: PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells. PMID: 16446371 Ref: Human and murine macrophages mediate activation of MEN 4901/T-0128: a new promising camptothecin analogue-polysaccharide conjugate. PMID: 17075311 |
Ref: Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance. PMID: 18676856 Ref: Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers. PMID: 18714186 Ref: Tissue microarrays of human tumor xenografts: characterization of proteins involved in migration and angiogenesis for applications in the development of targeted anticancer agents. PMID: 19129557 |
Ref: Cathepsin B is a target of Hedgehog signaling in pancreatic cancer. PMID: 19004543 Ref: Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. PMID: 19208367 Ref: Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells. PMID: 19271729 Ref: Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice. PMID: 20079165 |
Ref: AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D. PMID: 21948970 |
Ref: Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice. PMID: 22157328 Ref: The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. PMID: 22450679 Ref: MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization. PMID: 22912777 |
Ref: Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. PMID: 22918166 Ref: 177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model. PMID: 23622691 Ref: Self-assembling, amphiphilic polymer-gemcitabine conjugate shows enhanced antitumor efficacy against human pancreatic adenocarcinoma. PMID: 23758084 |
Ref: [Impact of chemotherapies on immunosuppression and discovery of new therapeutic targets]. PMID: 24899072 |
Ref: Antitumor effect of antitissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts. PMID: 25704403 Ref: Enhanced cellular uptake and intracellular drug controlled release of VESylated gemcitabine prodrug nanocapsules. PMID: 25746328 |
Ref: Dual Enzymatic Reaction-Assisted Gemcitabine Delivery Systems for Programmed Pancreatic Cancer Therapy. PMID: 28071891 Ref: Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells. PMID: 28139733 Ref: Enzyme-sensitive gemcitabine conjugated albumin nanoparticles as a versatile theranostic nanoplatform for pancreatic cancer treatment. PMID: 28800445 |
Ref: Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors. PMID: 29782949 Ref: Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB. PMID: 30086361 |