Primary Site >> Liver Cancer
Gene >> CTNNB1
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Ref: Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma. PMID: 10398436 Ref: The role of the E-cadherin/catenin complex in gastrointestinal cancer. PMID: 10692769 |
Ref: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. PMID: 10700176 |
Ref: P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells. PMID: 12439747 Ref: Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. PMID: 12460462 Ref: Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. PMID: 12481159 |
Ref: Identification of the LIM protein FHL2 as a coactivator of beta-catenin. PMID: 12466281 Ref: Loss of beta-catenin expression in metastatic gastric cancer. PMID: 12721245 |
Ref: Clinical and molecular analysis of combined hepatocellular-cholangiocarcinomas. PMID: 15288479 |
Ref: Genotype-phenotype relationships in hepatocellular tumors from mice and man. PMID: 15965925 |
Ref: Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors. PMID: 16465411 Ref: APC and CTNNB1 mutations are rare in sporadic ependymomas. PMID: 16843107 Ref: Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report. PMID: 16897741 Ref: Rex3 (reduced in expression 3) as a new tumor marker in mouse hepatocarcinogenesis. PMID: 16959394 Ref: Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. PMID: 17035233 Ref: Targeting the active beta-catenin pathway to treat cancer cells. PMID: 17121933 |
Ref: Genomic stability prevails in North-African hepatocellular carcinomas. PMID: 17531558 Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. PMID: 17675336 Ref: Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools. PMID: 17690210 Ref: Proteome analysis of chemically induced mouse liver tumors with different genotype. PMID: 17722141 Ref: siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. PMID: 18030363 |
Ref: Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. PMID: 18264082 Ref: Ser-249 TP53 and CTNNB1 mutations in circulating free DNA of Egyptian patients with hepatocellular carcinoma versus chronic liver diseases. PMID: 18313840 Ref: Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma. PMID: 18592156 Ref: Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. PMID: 18701503 Ref: Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. PMID: 18781563 |
Ref: Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. PMID: 19101982 Ref: Altered microRNA Expression Patterns in Hepatoblastoma Patients. PMID: 19701500 |
Ref: URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. PMID: 19413886 Ref: Personalized molecular targeted therapy in advanced, recurrent hepatocellular carcinoma after liver transplantation: a proof of principle. PMID: 20347502 Ref: Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma. PMID: 20923573 Ref: Characterization of HuH6, Hep3B, HepG2 and HLE liver cancer cell lines by WNT/beta - catenin pathway, microRNA expression and protein expression profile. PMID: 20937217 |
Ref: Hepatitis B virus-associated hepatocellular carcinoma from India: role of viral genotype and mutations in CTNNB1 (beta-catenin) and TP53 genes. PMID: 20963515 Ref: Tumor formation in liver of conditional beta-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen. PMID: 21047994 Ref: MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. PMID: 21324318 Ref: Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management. PMID: 21339346 Ref: Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma. PMID: 21615622 Ref: Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand. PMID: 21760996 Ref: Phenotype of single hepatocytes expressing an activated version of beta-catenin in liver of transgenic mice. PMID: 21822615 Ref: Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review. PMID: 21966251 Ref: HGF/c-Met related activation of beta-catenin in hepatoblastoma. PMID: 21992464 Ref: Depletion of beta-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. PMID: 22042854 |
Ref: GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation. PMID: 21835143 Ref: Zinc finger transcription factor 191, directly binding to beta-catenin promoter, promotes cell proliferation of hepatocellular carcinoma. PMID: 22213192 Ref: Resection of adrenocortical carcinoma liver metastasis: is it justified? PMID: 22526905 Ref: Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. PMID: 22561517 Ref: Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. PMID: 22811581 Ref: MiR-214 targets beta-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma. PMID: 22962603 Ref: Fibrolamellar carcinoma: 2012 update. PMID: 24278737 |
Ref: Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I. PMID: 23046672 Ref: Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways. PMID: 23262642 Ref: Genetics and epigenetics of liver cancer. PMID: 23392071 Ref: Molecular classification of hepatocellular adenomas. PMID: 23401783 Ref: Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma. PMID: 23428866 Ref: Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification. PMID: 23463346 Ref: Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen. PMID: 23479080 Ref: Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections. PMID: 23583669 Ref: Signal transduction disturbance related to hepatocarcinogenesis in mouse by prolonged exposure to Nanjing drinking water. PMID: 23591932 Ref: Identification of driver genes in hepatocellular carcinoma by exome sequencing. PMID: 23728943 Ref: Somatic changes in primary liver cancer in Russia: a pilot study. PMID: 23830926 Ref: High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. PMID: 23887712 Ref: Downregulation of miR-200a induces EMT phenotypes and CSC-like signatures through targeting the beta-catenin pathway in hepatic oval cells. PMID: 24260215 Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID: 24379610 |
Ref: Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. PMID: 24242335 Ref: ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ss-catenin pathway. PMID: 24276407 Ref: Ha-ras and beta-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors. PMID: 24535843 Ref: Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design. PMID: 24589894 Ref: Genome-wide transcriptional sequencing identifies novel mutations in metabolic genes in human hepatocellular carcinoma. PMID: 24633315 Ref: Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. PMID: 24798001 Ref: Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PMID: 24798046 Ref: Identification and characterization of a novel small-molecule inhibitor of beta-catenin signaling. PMID: 24819961 Ref: beta-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastoma. PMID: 24848510 Ref: Genetic ablation of beta-catenin inhibits the proliferative phenotype of mouse liver adenomas. PMID: 24874479 Ref: Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PMID: 24892551 Ref: Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex. PMID: 24912477 Ref: Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID: 24931142 Ref: Integrated analysis of mutation data from various sources identifies key genes and signaling pathways in hepatocellular carcinoma. PMID: 24988079 Ref: beta-catenin (CTNNB1) mutations are not associated with prognosis in advanced hepatocellular carcinoma. PMID: 25012536 Ref: Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations. PMID: 25016225 Ref: TALEN-mediated somatic mutagenesis in murine models of cancer. PMID: 25070752 Ref: Glutamine depletion by crisantaspase hinders the growth of human hepatocellular carcinoma xenografts. PMID: 25072259 Ref: The genomic landscape of hepatoblastoma and their progenies with HCC-like features. PMID: 25135868 Ref: Diverse modes of genomic alteration in hepatocellular carcinoma. PMID: 25159915 Ref: CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma. PMID: 25277196 Ref: A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma. PMID: 25502816 Ref: Profiling of exome mutations associated with progression of HBV-related hepatocellular carcinoma. PMID: 25521761 |
Ref: Integration of tumour and viral genomic characterizations in HBV-related hepatocellular carcinomas. PMID: 25021421 Ref: Intratumor heterogeneity in hepatocellular carcinoma. PMID: 25248380 Ref: The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of beta-catenin in HCC cells. PMID: 25449213 Ref: Complete response of Ctnnb1-mutated tumours to beta-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. PMID: 25457204 Ref: Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia. PMID: 25536643 Ref: beta-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. PMID: 25747274 Ref: YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. PMID: 25772357 Ref: Nrf2, but not beta-catenin, mutation represents an early event in rat hepatocarcinogenesis. PMID: 25783764 Ref: Wnt/beta-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. PMID: 25813403 Ref: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. PMID: 25822088 Ref: Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma. PMID: 25901726 Ref: Alterations of Wnt/beta-catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus. PMID: 26017875 Ref: Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma. PMID: 26034368 Ref: Targeted DNA and RNA sequencing of fine-needle biopsy FFPE specimens in patients with unresectable hepatocellular carcinoma treated with sorafenib. PMID: 26046304 Ref: Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. PMID: 26099527 Ref: New molecular therapies for hepatocellular carcinoma. PMID: 26206572 Ref: E-cadherin can limit the transforming properties of activating beta-catenin mutations. PMID: 26240067 Ref: Liver cancer oncogenomics: opportunities and dilemmas for clinical applications. PMID: 26257864 Ref: ARID2, p110alpha, p53, and beta-catenin protein expression in hepatocellular carcinoma and clinicopathologic implications. PMID: 26284269 Ref: Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice. PMID: 26289556 Ref: beta-catenin alteration is rare in hepatocellular carcinoma with steatohepatitic features: immunohistochemical and mutational study. PMID: 26311355 Ref: Evaluation of CTNNB1 and TP53 variability in patients with hepatocellular carcinoma and occult hepatitis B virus infection. PMID: 26341700 Ref: Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations. PMID: 26431491 Ref: Hepatocellular Carcinoma Arising in an HNF-1alpha-Mutated Adenoma in a 23-Year-Old Woman with Maturity-Onset Diabetes of the Young: A Case Report. PMID: 26676820 Ref: A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1. PMID: 26715116 |
Ref: Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F(2) male offspring via the F(1) male offspring. PMID: 25825268 Ref: Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1. PMID: 25964079 Ref: TERT promoter mutations in primary liver tumors. PMID: 26336998 Ref: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. PMID: 26553052 Ref: Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options. PMID: 26661118 Ref: Targeted and exome sequencing identified somatic mutations in hepatocellular carcinoma. PMID: 26850916 Ref: PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway. PMID: 26915315 Ref: Armc8 regulates the invasive ability of hepatocellular carcinoma through E-cadherin/catenin complex. PMID: 26944057 Ref: Genetic polymorphisms in the Wnt/beta-catenin pathway genes as predictors of tumor development and survival in patients with hepatitis B virus-associated hepatocellular carcinoma. PMID: 26968103 Ref: Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant beta-catenin. PMID: 27097116 Ref: Diverse Basis of beta-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis. PMID: 27100093 Ref: Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing. PMID: 27248174 Ref: Liver cancer with concomitant TP53 and CTNNB1 mutations: a case report. PMID: 27252594 Ref: Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma. PMID: 27276713 Ref: Direct Pharmacological Inhibition of beta-Catenin by RNA Interference in Tumors of Diverse Origin. PMID: 27390343 Ref: Correlation of exon 3 beta-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. PMID: 27469330 Ref: TERT promoter mutations and chromosome 8p loss are characteristic of nonalcoholic fatty liver disease-related hepatocellular carcinoma. PMID: 27511114 Ref: Epigenetic Activation of Wnt/beta-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis. PMID: 27556491 Ref: Frequent somatic TERT promoter mutations and CTNNB1 mutations in hepatocellular carcinoma. PMID: 27661004 Ref: Detecting Circulating Tumor DNA in Hepatocellular Carcinoma Patients Using Droplet Digital PCR Is Feasible and Reflects Intratumoral Heterogeneity. PMID: 27698932 Ref: miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/beta-catenin signaling pathway. PMID: 27738331 Ref: Integrated Multiple "-omics" Data Reveal Subtypes of Hepatocellular Carcinoma. PMID: 27806083 Ref: Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of beta-Catenin Signaling. PMID: 27851986 Ref: C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive beta-catenin/BAMBI signaling. PMID: 27909336 |
Ref: Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. PMID: 27618837 Ref: Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer. PMID: 27838634 Ref: Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. PMID: 27939373 Ref: Targeting beta-catenin in hepatocellular cancers induced by coexpression of mutant beta-catenin and K-Ras in mice. PMID: 27981621 Ref: Malignant transformation of a beta-catenin inflammatory adenoma due to an S45 beta-catenin-activating mutation present 12 years before. PMID: 27984126 Ref: Germline and somatic DICER1 mutations in familial and sporadic liver tumors. PMID: 28012864 Ref: Gene Signature Associated with Upregulation of the Wnt/beta-Catenin Signaling Pathway Predicts Tumor Response to Transarterial Embolization. PMID: 28126478 Ref: Constitutional and functional genetics of human alcohol-related hepatocellular carcinoma. PMID: 28296015 Ref: Influence of polymorphisms in the Wnt/beta-catenin pathway genes on hepatocellular carcinoma risk in a Chinese Han population. PMID: 28328801 Ref: Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro. PMID: 28419472 Ref: Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma. PMID: 28529542 Ref: Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. PMID: 28532995 Ref: Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy. PMID: 28651018 Ref: Molecular classification of hepatocellular adenoma in clinical practice. PMID: 28733222 Ref: TTK Inhibitors as a Targeted Therapy for CTNNB1 (beta-catenin) Mutant Cancers. PMID: 28751540 Ref: Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer. PMID: 28807594 Ref: Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma. PMID: 28843658 Ref: The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. PMID: 28854942 Ref: Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma. PMID: 28923827 Ref: Oncogenic dependency on beta-catenin in liver cancer cell lines correlates with pathway activation. PMID: 29383099 Ref: Clinicopathologic characteristics of Wnt/beta-catenin-deregulated hepatocellular carcinoma. PMID: 30082549 |
Ref: New advances of TMEM88 in cancer initiation and progression, with special emphasis on Wnt signaling pathway. PMID: 28181235 Ref: beta-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic beta-catenin and MET. PMID: 29152756 Ref: Over-expression of oncigenic pesudogene DUXAP10 promotes cell proliferation and invasion by regulating LATS1 and beta-catenin in gastric cancer. PMID: 29374493 Ref: Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next-generation sequencing. PMID: 29391887 Ref: Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity. PMID: 29408647 Ref: The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, beta-Catenin-Mutated Mouse Model. PMID: 29409568 Ref: Downregulated miR-23b-3p expression acts as a predictor of hepatocellular carcinoma progression: A study based on public data and RT-qPCR verification. PMID: 29484429 Ref: Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma. PMID: 29487225 Ref: Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. PMID: 29512829 Ref: Hepatocyte Wnts Are Dispensable During Diethylnitrosamine and Carbon Tetrachloride-Induced Injury and Hepatocellular Cancer. PMID: 29519268 Ref: AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of beta-catenin activation. PMID: 29525529 Ref: beta-catenin-activated hepatocellular carcinomas are addicted to fatty acids. PMID: 29650531 Ref: Tumor Molecular Profiling for an Individualized Approach to the Treatment of Hepatocellular Carcinoma: A Patient Case Study. PMID: 29673151 Ref: Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines. PMID: 29735783 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Genomic structures of dysplastic nodule and concurrent hepatocellular carcinoma. PMID: 29949741 Ref: Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with RAS-Mutated Hepatocellular Carcinoma. PMID: 29950351 Ref: MicroRNA-298 represses hepatocellular carcinoma progression by inhibiting CTNND1-mediated Wnt/beta-catenin signaling. PMID: 29990836 Ref: Host and Viral Genetic Variation in HBV-Related Hepatocellular Carcinoma. PMID: 30073017 Ref: High Frequency of beta-Catenin Mutations in Mouse Hepatocellular Carcinomas Induced by a Nongenotoxic Constitutive Androstane Receptor Agonist. PMID: 30201494 Ref: Multi-modal meta-analysis of 1494 hepatocellular carcinoma samples reveals significant impact of consensus driver genes on phenotypes. PMID: 30242023 Ref: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/beta-Catenin Signaling. PMID: 30257989 Ref: Molecular Scoring of Hepatocellular Carcinoma for Predicting Metastatic Recurrence and Requirements of Systemic Chemotherapy. PMID: 30274313 |