Primary Site >> Colorectal Cancer
Gene >> CHFR
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Ref: Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. PMID: 12538348 Ref: Epigenetic inactivation of CHFR in human tumors. PMID: 12810945 Ref: Chfr inactivation is not associated to chromosomal instability in colon cancers. PMID: 14654793 |
Ref: CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. PMID: 15760919 |
Ref: Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer. PMID: 16502017 Ref: Promoter methylation precedes chromosomal alterations in colorectal cancer development. PMID: 17167178 Ref: Aberrant methylation of the CHFR gene is frequently detected in non-invasive colorectal cancer. PMID: 17201143 |
Ref: Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations. PMID: 18048385 Ref: Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk. PMID: 18079053 Ref: CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. PMID: 18204436 Ref: Epigenetic signatures of familial cancer are characteristic of tumor type and family category. PMID: 18559504 Ref: Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PMID: 19002263 |
Ref: CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. PMID: 18832519 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. PMID: 19470733 Ref: A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. PMID: 19686742 Ref: Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. PMID: 19690386 |
Ref: CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients. PMID: 19956881 Ref: Epigenetic drivers of genetic alterations. PMID: 20920753 Ref: Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. PMID: 21037082 Ref: Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer. PMID: 21187457 |
Ref: Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b. PMID: 20831567 Ref: Methylation profiling of rectal cancer identifies novel markers of early-stage disease. PMID: 21360524 Ref: Association of CHFR promoter methylation with disease recurrence in locally advanced colon cancer. PMID: 21551253 Ref: B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP). PMID: 21738611 |
Ref: CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer. PMID: 23873170 Ref: CHFR promoter methylation indicates poor prognosis in stage II microsatellite stable colorectal cancer. PMID: 24928946 Ref: Biomarker-based treatment selection in early-stage rectal cancer to promote organ preservation. PMID: 25052224 |
Ref: Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma. PMID: 26756304 Ref: Arsenic trioxide induces cell cycle arrest and alters DNA methylation patterns of cell cycle regulatory genes in colorectal cancer cells. PMID: 27769816 |
Ref: The diagnostic and prognostic value of CHFR hypermethylation in colorectal cancer, a meta-analysis and literature review. PMID: 29179506 |
Ref: Phase II study of nab-paclitaxel in refractory small bowel adenocarcinoma and CpG island methylator phenotype (CIMP)-high colorectal cancer. PMID: 29069279 |