Primary Site >> Colorectal Cancer
Gene >> CFLAR
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Ref: Nasal and sinonasal cancer. Connection with occupational exposures in Denmark, Finland and Sweden. PMID: 6635610 |
Ref: [Methodological aspects on the histological evaluation of subrenal capsule assay (SRCA)]. PMID: 2108610 |
Ref: Sensitization of human colon cancer cells to TRAIL-mediated apoptosis. PMID: 11309649 Ref: Serum levels of selenium, manganese, copper, and iron in colorectal cancer patients. PMID: 11330516 Ref: Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL-sensitive colon carcinoma cell line SW480 using a genetic approach. PMID: 11486001 Ref: Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis. PMID: 11490359 Ref: Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. PMID: 11526513 |
Ref: Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway. PMID: 11821946 Ref: Mechanisms involved in development of resistance to adenovirus-mediated proapoptotic gene therapy in DLD1 human colon cancer cell line. PMID: 12215894 Ref: Defining characteristics of Types I and II apoptotic cells in response to TRAIL. PMID: 12407450 |
Ref: Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells. PMID: 12618891 Ref: The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. PMID: 12902978 |
Ref: Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. PMID: 14729063 Ref: Regulation of caspase-6 and FLIP by the AMPK family member ARK5. PMID: 15273717 Ref: Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy. PMID: 15790545 |
Ref: Meat intake, cooking-related mutagens and risk of colorectal adenoma in a sigmoidoscopy-based case-control study. PMID: 15579480 Ref: Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer. PMID: 15832422 Ref: Cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis in human colorectal cancer cell line COLO 205; role of FLIP and metabolic inhibitors. PMID: 16077198 Ref: Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation. PMID: 16082182 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. PMID: 16373718 |
Ref: PKCdelta-mediated regulation of FLIP expression in human colon cancer cells. PMID: 16052516 Ref: c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. PMID: 16247474 Ref: Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. PMID: 16306425 Ref: Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). PMID: 16820966 Ref: Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. PMID: 17145853 Ref: Overview how adenocarcinoma cancer cells avoid immune- and chemotherapy-induced apoptosis. PMID: 17357275 |
Ref: Expression of anti-apoptotic factors modulates Apo2L/TRAIL resistance in colon carcinoma cells. PMID: 17440816 Ref: c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications. PMID: 17559541 Ref: c-FLIP: a key regulator of colorectal cancer cell death. PMID: 17575142 Ref: Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling. PMID: 17578896 Ref: Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF. PMID: 17603079 Ref: Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients. PMID: 17785559 Ref: Antiapoptotic proteins as targets for bioactive compounds. PMID: 17882939 Ref: Sodium butyrate-dependent sensitization of human colon adenocarcinoma COLO 205 cells to TNF-alpha-induced apoptosis. PMID: 17901592 Ref: [The anti-diabetic drug troglitazone sensitizes colon cancer cells to TRAIL-induced apoptosis by down-regulating FLIP]. PMID: 18314627 |
Ref: Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers. PMID: 18202809 Ref: Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29. PMID: 18243739 Ref: Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. PMID: 18521906 |
Ref: Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells. PMID: 18820704 Ref: Sodium butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNF-alpha-dependent extrinsic apoptosis. PMID: 19130237 Ref: A mathematical model of doxorubicin penetration through multicellular layers. PMID: 19183560 Ref: S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells. PMID: 19372210 Ref: Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. PMID: 19483104 Ref: Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic. PMID: 19638488 |
Ref: Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells. PMID: 19577358 Ref: Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation. PMID: 19798106 Ref: Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells. PMID: 20087343 Ref: Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo. PMID: 20137855 Ref: Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin. PMID: 20424169 Ref: Prognostic significance of TRAIL signaling molecules in stage II and III colorectal cancer. PMID: 20570920 Ref: Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines. PMID: 20811726 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 |
Ref: Death receptor 5-mediated TNFR family signaling pathways modulate gamma-humulene-induced apoptosis in human colorectal cancer HT29 cells. PMID: 21152878 Ref: Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome). PMID: 21165777 Ref: [Steatohepatitis after chemotherapy for colorectal liver metastases (CASH)]. PMID: 21681471 Ref: Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3. PMID: 21868755 |
Ref: Systemic lupus erythematosus associated with Wells' syndrome. PMID: 21340570 Ref: Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model. PMID: 21480219 Ref: Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype. PMID: 22018732 Ref: A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer. PMID: 22027693 Ref: Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression. PMID: 22086925 Ref: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. PMID: 22322857 Ref: Sub-lethal irradiation of human colorectal tumor cells imparts enhanced and sustained susceptibility to multiple death receptor signaling pathways. PMID: 22389673 Ref: Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer. PMID: 22859720 |
Ref: Targeting FLIP and Mcl-1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL. PMID: 23132258 Ref: The plant alkaloid and anti-leukemia drug homoharringtonine sensitizes resistant human colorectal carcinoma cells to TRAIL-induced apoptosis via multiple mechanisms. PMID: 23456623 Ref: Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells. PMID: 23559011 Ref: Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors. PMID: 23732517 Ref: Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. PMID: 24118446 |
Ref: Expression of apoptosis regulating proteins identifies stage II and III colon cancer patients with high risk of recurrence. PMID: 24249458 Ref: Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer. PMID: 24503538 Ref: Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine. PMID: 25200008 Ref: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors. PMID: 25482938 |
Ref: HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL. PMID: 25813020 Ref: MiR-492 is functionally involved in Oxaliplatin resistance in colon cancer cells LS174T via its regulating the expression of CD147. PMID: 25862460 Ref: Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo". PMID: 26051518 Ref: Goniothalamin enhances TRAIL-induced apoptosis in colorectal cancer cells through DR5 upregulation and cFLIP downregulation. PMID: 26499766 Ref: [Sensitization of human colon cancer HT-29 cells to TRAIL-induced apoptosis by gambognic acid]. PMID: 26837170 |
Ref: The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer. PMID: 26771233 Ref: 2D radially compensating excitation pulse in combination with an internal transceiver antenna for 3D MRI of the rectum at 7 T. PMID: 27370152 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 |
Ref: Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells. PMID: 27940194 Ref: Genome-wide network-based pathway analysis of CSF t-tau/Abeta1-42 ratio in the ADNI cohort. PMID: 28558704 Ref: TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis. PMID: 29118756 |
Ref: Evaluating Two Evidence-Based Intervention Strategies to Promote CRC Screening Among Latino Adults in a Primary Care Setting. PMID: 28634873 Ref: Trace Element and Heavy Metal Levels in Colorectal Cancer: Comparison Between Cancerous and Non-cancerous Tissues. PMID: 28795369 Ref: Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells. PMID: 29397735 Ref: Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells. PMID: 29684585 Ref: Clinical lymph node staging in colorectal cancer; a flip of the coin? PMID: 29739638 Ref: miR218 promotes apoptosis of SW1417 human colon cancer cells by targeting cFLIP. PMID: 29845219 Ref: Polyamino Acid Layer-by-Layer (LbL) Constructed Silica-Supported Mesoporous Titania Nanocarriers for Stimuli-Responsive Delivery of microRNA 708 and Paclitaxel for Combined Chemotherapy. PMID: 29978708 Ref: Correlation Between Intravoxel Incoherent Motion and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters in Rectal Cancer. PMID: 30268719 Ref: Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling. PMID: 30378164 |