Primary Site >> Colorectal Cancer

Gene >> CES2

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Ref: Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines.
PMID: 11914913
Ref: Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan.
PMID: 12171891
Ref: Secreted and tumour targeted human carboxylesterase for activation of irinotecan.
PMID: 12237777
 Ref: Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.
PMID: 14581373
 Ref: Unfavourable expression of pharmacologic markers in mucinous colorectal cancer.
PMID: 15655543
Ref: Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.
PMID: 15687373
Ref: Carboxylesterase isoform 2 mRNA expression in peripheral blood mononuclear cells is a predictive marker of the irinotecan to SN38 activation step in colorectal cancer patients.
PMID: 16203781
 Ref: Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway.
PMID: 16963839
 Ref: Expression and characterization of a human carboxylesterase 2 splice variant.
PMID: 17636009
 Ref: Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene.
PMID: 17483951
Ref: Carboxylesterase 2 is downregulated in colorectal cancer following progression of the disease.
PMID: 18259949
Ref: A carboxylesterase 2 gene polymorphism as predictor of capecitabine on response and time to progression.
PMID: 18473752
Ref: Pharmacokinetic and pharmacogenetic determinants of the activity and toxicity of irinotecan in metastatic colorectal cancer patients.
PMID: 18797458
 Ref: Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.
PMID: 19359405
Ref: Decreased serum levels of carboxylesterase-2 in patients with ovarian cancer.
PMID: 19856659
 Ref: Evidence of heterogeneity within colorectal liver metastases for allelic losses, mRNA level expression and in vitro response to chemotherapeutic agents.
PMID: 20017140
 Ref: A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome.
PMID: 21325291
Ref: A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery.
PMID: 21931543
 Ref: Phase II and gene expression analysis trial of neoadjuvant capecitabine plus irinotecan followed by capecitabine-based chemoradiotherapy for locally advanced rectal cancer: Hoosier Oncology Group GI03-53.
PMID: 22610353
 Ref: Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug.
PMID: 23373735
 Ref: Relationship between the expression of CES2, UGT1A1, and GUSB in colorectal cancer tissues and aberrant methylation.
PMID: 24195516
Ref: Regulation and expression of aberrant methylation on irinotecan metabolic genes CES2, UGT1A1 and GUSB in the in-vitro cultured colorectal cancer cells.
PMID: 24439671
Ref: Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.
PMID: 25047517
Ref: CES2, ABCG2, TS and Topo-I primary and synchronous metastasis expression and clinical outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI regimen.
PMID: 25198900
Ref: Influence of UGT1A1 gene methylation level in colorectal cancer cells on the sensitivity of the chemotherapy drug CPT-11.
PMID: 25260839
 Ref: Tissue-infiltrating plasma cells are an important source of carboxylesterase 2 contributing to the therapeutic efficacy of prodrugs.
PMID: 27149931
Ref: High-throughput proteomics integrated with gene microarray for discovery of colorectal cancer potential biomarkers.
PMID: 27661117
 Ref: Glycoengineering of Esterase Activity through Metabolic Flux-Based Modulation of Sialic Acid.
PMID: 28218815
 Ref: The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer.
PMID: 29651325
Ref: Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies.
PMID: 29709907