Primary Site >> Colorectal Cancer
Gene >> CES1
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Ref: Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells. PMID: 1639221 |
Ref: Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines. PMID: 11914913 Ref: Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. PMID: 12171891 |
Ref: Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. PMID: 14581373 |
Ref: Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. PMID: 15687373 |
Ref: Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity. PMID: 18077151 |
Ref: Phase II and gene expression analysis trial of neoadjuvant capecitabine plus irinotecan followed by capecitabine-based chemoradiotherapy for locally advanced rectal cancer: Hoosier Oncology Group GI03-53. PMID: 22610353 |
Ref: Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen. PMID: 25047517 |
Ref: 3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells. PMID: 25576862 |
Ref: Colorectal multidisciplinary meetings: how do they affect the timeliness of treatment? PMID: 25913227 Ref: Glycoengineering of Esterase Activity through Metabolic Flux-Based Modulation of Sialic Acid. PMID: 28218815 Ref: Identification of new SNPs associated with severe toxicity to capecitabine. PMID: 28347776 |
Ref: Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies. PMID: 29709907 |