Primary Site >> Colorectal Cancer
Gene >> CDX2
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Ref: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. PMID: 9036867 Ref: Cloning and chromosome assignment of the human CDX2 gene. PMID: 9459001 |
Ref: Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. PMID: 9593754 Ref: CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. PMID: 9704932 |
Ref: CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. PMID: 10490837 |
Ref: Overexpression of Cdx1 and Cdx2 homeogenes enhances expression of the HLA-I in HT-29 cells. PMID: 10964750 |
Ref: The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis. PMID: 11161380 Ref: CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers. PMID: 11355940 Ref: Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. PMID: 11521200 |
Ref: The caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells. PMID: 11743638 Ref: Stimulation of the intestinal Cdx2 homeobox gene by butyrate in colon cancer cells. PMID: 11889074 Ref: Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein. PMID: 11997022 Ref: Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. PMID: 12117877 Ref: CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia. PMID: 12404231 |
Ref: CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. PMID: 12604886 Ref: Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. PMID: 12855703 Ref: Silencing of CDX2 expression in colon cancer via a dominant repression pathway. PMID: 12947088 Ref: Oncocytic adenocarcinoma of the rectum with diffuse intra-luminal microcalcifications: the first reported case. PMID: 12955503 Ref: The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. PMID: 12970140 Ref: CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. PMID: 12970742 Ref: Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays. PMID: 13679455 Ref: Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability. PMID: 14500396 Ref: Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. PMID: 14625550 |
Ref: Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. PMID: 15013430 Ref: Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. PMID: 15087663 Ref: The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. PMID: 15190067 Ref: Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. PMID: 15215241 Ref: Immunophenotypic differences between intestinal-type and low-grade papillary sinonasal adenocarcinomas: an immunohistochemical study of 22 cases utilizing CDX2 and MUC2. PMID: 15252308 Ref: Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. PMID: 15327990 Ref: Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma. PMID: 15362373 Ref: Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. PMID: 15466189 Ref: CDX-2 expression is reduced in colorectal carcinomas with solid growth pattern and proximal location, but is largely independent of MSI status. PMID: 15619975 |
Ref: Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. PMID: 15389251 Ref: Promoter methylation downregulates CDX2 expression in colorectal carcinomas. PMID: 15706431 Ref: CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. PMID: 15732140 Ref: Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. PMID: 15774940 Ref: Value of CDX2, villin, and alpha-methylacyl coenzyme A racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. PMID: 15803184 Ref: CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium. PMID: 15825077 Ref: Expression of CDX2, cytokeratins 7 and 20 in sinonasal intestinal-type adenocarcinoma. PMID: 15894926 Ref: CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. PMID: 15994917 Ref: Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. PMID: 16027724 Ref: Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis. PMID: 16143030 Ref: [Expression of Cdx2 protein in colorectal cancer]. PMID: 16179840 Ref: Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso. PMID: 16273256 Ref: Potential diagnostic utility of CDX-2 immunophenotyping in extramammary Paget's disease. PMID: 16280663 Ref: The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. PMID: 16361536 Ref: Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. PMID: 16491830 |
Ref: CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. PMID: 16314840 Ref: Altered expression of CDX2 in colorectal cancers. PMID: 16499661 Ref: Invasive colorectal micropapillary carcinoma: an aggressive variant of adenocarcinoma. PMID: 16784979 |
Ref: Expression of CDX2 in benign tissue and adenocarcinoma of the prostate. PMID: 16949907 Ref: Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. PMID: 17163399 Ref: The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. PMID: 17255339 Ref: Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma. PMID: 17295772 Ref: CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3. PMID: 17297462 Ref: Distinguishing prostatic from colorectal adenocarcinoma on biopsy samples: the role of morphology and immunohistochemistry. PMID: 17425391 Ref: Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. PMID: 17534889 Ref: CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens. PMID: 17549351 Ref: CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer. PMID: 17906616 Ref: Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. PMID: 17923376 Ref: Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. PMID: 17942902 Ref: CDX2 VDR polymorphism and colorectal cancer. PMID: 18086783 |
Ref: The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. PMID: 17599044 Ref: Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. PMID: 18187048 Ref: Prostatic adenocarcinoma in colorectal biopsy: clinical and pathologic features. PMID: 18234278 Ref: Clinicopathological analysis of colorectal cancer liver metastasis and intrahepatic cholangiocarcinoma: are they just apples and oranges? PMID: 18329969 Ref: Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. PMID: 18372917 Ref: Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions. PMID: 18510991 Ref: Expression of homeodomain protein CDX2 in colorectal adenoma and adenocarcinoma. PMID: 18581275 Ref: Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. PMID: 18587323 Ref: Invasive micropapillary carcinoma of the sigmoid colon: distinct morphology and aggressive behavior. PMID: 18787620 Ref: Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2. PMID: 18819935 Ref: KLF4 regulation in intestinal epithelial cell maturation. PMID: 18977346 |
Ref: Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. PMID: 18992263 Ref: Differentiating the undifferentiated: immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation. PMID: 18992917 Ref: Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. PMID: 19188603 Ref: No association between the polymorphisms in CDX2 coding regions and colorectal cancer in Chinese. PMID: 19421714 Ref: KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. PMID: 19551868 Ref: Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. PMID: 19584150 Ref: The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature. PMID: 19667145 Ref: Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. PMID: 19686845 Ref: Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2. PMID: 19781065 Ref: Colonic carcinoma with a pancreatic acinar cell differentiation. A case report. PMID: 19908063 Ref: CDX2 expression in cutaneous metastatic carcinomas and extramammary Paget's Disease. PMID: 20044613 Ref: Purification of caudal-related homeodomain transcription factor and its binding characterization. PMID: 20075618 Ref: [Pathologic study of circumferential margin involvement in middle and lower rectal cancer]. PMID: 20137717 Ref: [Differential diagnostic importance of immunochistochemistry applied at metastases of adenocarcinomas of the peritoneum]. PMID: 20198793 |
Ref: The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta-catenin-TCF protein complex. PMID: 19734199 Ref: Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas. PMID: 19800103 Ref: CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. PMID: 19900445 Ref: Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. PMID: 19908233 Ref: CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. PMID: 19926591 Ref: Ampullary cancer. PMID: 20168227 Ref: Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors. PMID: 20432164 Ref: Hypoxia-inducible factor-1alpha modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer. PMID: 20514449 Ref: New insights into the development and differentiation of the human anorectal epithelia. Are there clinical consequences? PMID: 20563874 Ref: Corruption of homeostatic mechanisms in the guanylyl cyclase C signaling pathway underlying colorectal tumorigenesis. PMID: 20592492 Ref: Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles. PMID: 20664940 Ref: Intestine-specific transcription factor Cdx2 induces E-cadherin function by enhancing the trafficking of E-cadherin to the cell membrane. PMID: 20671195 Ref: TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. PMID: 20696899 Ref: CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium. PMID: 20699370 Ref: Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. PMID: 20716165 Ref: Immunohistochemical analysis of colorectal cancer with gastric phenotype: claudin-18 is associated with poor prognosis. PMID: 20846265 |
Ref: Colonic carcinoma metastatic to the endometrium: the importance of clinical history in averting misdiagnosis as a primary endometrial carcinoma. PMID: 19443868 Ref: Immunohistochemical expression of CDX2, beta-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer. PMID: 20815042 Ref: Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. PMID: 21051540 Ref: Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. PMID: 21224344 Ref: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer. PMID: 21233674 Ref: Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines. PMID: 21284881 Ref: A novel case of rhabdoid colon carcinoma associated with a positive CpG island methylator phenotype and BRAF mutation. PMID: 21315413 Ref: Clinical significance of CDX2-positive circulating tumour cells in colorectal cancer patients. PMID: 21364588 Ref: Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. PMID: 21378269 Ref: Filiform serrated adenomatous polyposis arising in a diverted rectum of an inflammatory bowel disease patient. PMID: 21569098 Ref: Small invasive colon cancer with systemic metastasis: a case report. PMID: 21595976 Ref: Effects of homeodomain protein CDX2 expression on the proliferation and migration of lovo colon cancer cells. PMID: 21626348 Ref: Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. PMID: 21660972 Ref: Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. PMID: 21664646 Ref: [A rare case of colorectal micropapillary carcinoma]. PMID: 22089678 Ref: [Advanced poorly differentiated adenocarcinoma of the colon with micropapillary carcinoma components except specific cytokeratin expressions, report of a case]. PMID: 22139489 Ref: Neuroendocrine and squamous colonic composite carcinoma: case report with molecular analysis. PMID: 22180717 Ref: Metastasis to the breast from colonic adenocarcinoma. PMID: 22319737 Ref: [The interaction between CDX2 transcription factor and DDX5 RNA helicase]. PMID: 22359951 |
Ref: Right-side and left-side colon cancer follow different pathways to relapse. PMID: 21656576 Ref: Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells. PMID: 22189105 Ref: Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and beta-catenin activity in colon cancer cells. PMID: 22202456 Ref: The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody. PMID: 22268990 Ref: Atypical presentation of colon adenocarcinoma: a case report. PMID: 22330123 Ref: Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. PMID: 22438068 Ref: Detection of human papillomavirus in small cell carcinomas of the anus and rectum. PMID: 22531171 Ref: Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition. PMID: 22547830 Ref: Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa. PMID: 22556146 Ref: Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells. PMID: 22719836 Ref: Vitamin D receptor polymorphisms in colorectal cancer in New Zealand: an association study. PMID: 22729058 Ref: Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. PMID: 22815676 Ref: Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma. PMID: 22895272 Ref: Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells. PMID: 22902753 Ref: CDX2 is an amplified lineage-survival oncogene in colorectal cancer. PMID: 23112155 Ref: Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. PMID: 23133598 Ref: Expression profiling of archival tumors for long-term health studies. PMID: 23136189 |
Ref: Regulation of the tumor suppressor homeogene Cdx2 by HNF4alpha in intestinal cancer. PMID: 22986531 Ref: Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2. PMID: 23045284 Ref: CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARgamma signaling. PMID: 23202735 Ref: Enteric adenocarcinoma lung: a rare presentation in an Omani woman. PMID: 23355573 Ref: Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. PMID: 23370770 Ref: Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells. PMID: 23393221 Ref: Right-sided rhabdoid colorectal tumors might be related to the serrated pathway. PMID: 23425390 Ref: Testicular metastasis of colorectal carcinoma: an unusual presentation. PMID: 23440985 Ref: Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation. PMID: 23517143 Ref: Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer. PMID: 23563447 Ref: Reduced CDX2 expression predicts poor overall survival in patients with colorectal cancer. PMID: 23574843 Ref: Endometriosis involving the mucosa of the intestinal tract: a clinicopathologic study of 15 cases. PMID: 23579618 Ref: Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. PMID: 23807779 Ref: The role of CDX2 in Caco-2 cell differentiation. PMID: 23958315 Ref: Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatellite-unstable colorectal cancer. PMID: 24025523 Ref: Vitamin D receptor polymorphism and colorectal cancer-specific and all-cause mortality. PMID: 24075799 Ref: Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer. PMID: 24130965 Ref: The chromatin remodelling component SMARCB1/INI1 influences the metastatic behavior of colorectal cancer through a gene signature mapping to chromosome 22. PMID: 24286138 |
Ref: Carcinoma of unknown primary with gastrointestinal profile: immunohistochemistry and survival data for this favorable subset. PMID: 23813044 Ref: Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. PMID: 23868178 Ref: Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. PMID: 24166180 Ref: Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model. PMID: 24212401 Ref: Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. PMID: 24437456 Ref: Involvement of CDX2 in the cross talk between TNF-alpha and Wnt signaling pathway in the colon cancer cell line Caco-2. PMID: 24501326 Ref: Highly sensitive detection of cancer cells based on the DNA barcode assay and microcapillary electrophoretic analysis. PMID: 24615960 Ref: Characterization of azoxymethane-induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy. PMID: 24670932 Ref: Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases. PMID: 24696747 Ref: Primary malignant mixed mullerian mesodermal tumor mimicking a rectosigmoid carcinoma: a case report and review of the literature. PMID: 24716055 Ref: Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer. PMID: 24764661 Ref: RSPO fusion transcripts in colorectal cancer in Japanese population. PMID: 24847761 Ref: Urethral metastasis from a sigmoid colon carcinoma: a quite rare case report and review of the literature. PMID: 24884559 Ref: BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical expression. PMID: 24908142 Ref: Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus barrier. PMID: 24925340 Ref: Expression of hippo pathway in colorectal cancer. PMID: 24976283 Ref: A novel CDX2 isoform regulates alternative splicing. PMID: 25101906 Ref: The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review. PMID: 25126956 Ref: A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding. PMID: 25131200 Ref: Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2). PMID: 25138215 Ref: Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition. PMID: 25229454 Ref: [Disappearance of a gastric lesion following modified FOLFOX6 chemotherapy in a patient with metastatic colorectal cancer: a case report and literature review]. PMID: 25283227 Ref: Cdx1 and Cdx2 function as tumor suppressors. PMID: 25320087 Ref: LEF-1 is frequently expressed in colorectal carcinoma and not in other gastrointestinal tract adenocarcinomas: an immunohistochemical survey of 602 gastrointestinal tract neoplasms. PMID: 25394300 Ref: Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PMID: 25423035 Ref: A case of clear cell adenocarcinoma arising from endometriosis of the rectum treated by laparoscopic surgery. PMID: 25460452 |
Ref: Silibinin modulates caudal-type homeobox transcription factor (CDX2), an intestine specific tumor suppressor to abrogate colon cancer in experimental rats. PMID: 24740923 Ref: Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid. PMID: 25034655 Ref: Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma. PMID: 25081749 Ref: B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. PMID: 25381152 Ref: Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities. PMID: 25663763 Ref: Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. PMID: 25663765 Ref: Gastric-type expression signature in serrated pathway-associated colorectal tumors. PMID: 25704805 Ref: Recombinant lentivirus with enhanced expression of caudal-related homeobox protein 2 inhibits human colorectal cancer cell proliferation in vitro. PMID: 25847407 Ref: Overexpression of caudal-related homeobox transcription factor 2 inhibits the growth of transplanted colorectal tumors in nude mice. PMID: 26005051 Ref: The value of SATB2 in the differential diagnosis of intestinal-type mucinous tumors of the ovary: primary vs metastatic. PMID: 26059401 Ref: MicroRNA-196b is transcribed from an autonomous promoter and is directly regulated by Cdx2 and by posterior Hox proteins during embryogenesis. PMID: 26141604 Ref: Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation. PMID: 26307678 Ref: Relationship among mismatch repair deficiency, CDX2 loss, p53 and E-cadherin in colon carcinoma and suitability of using a double panel of mismatch repair proteins by immunohistochemistry. PMID: 26619103 Ref: TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer. PMID: 26631571 Ref: MicroRNA profiling of primary pulmonary enteric adenocarcinoma in members from the same family reveals some similarities to pancreatic adenocarcinoma-a step towards personalized therapy. PMID: 26677401 Ref: [A Case of Sigmoid Colon Cancer with Metastasis to the Uterus]. PMID: 26805130 Ref: [A Case of Surgical Resection of a Liver Metastasis from Colorectal Cancer with a Macroscopic Portal Vein Tumor Thrombus]. PMID: 26805195 |
Ref: Meta-analysis on vitamin D receptor and cancer risk: focus on the role of TaqI, ApaI, and Cdx2 polymorphisms. PMID: 25738688 Ref: Are clinicopathological features of colorectal cancers with methylation in half of CpG island methylator phenotype panel markers different from those of CpG island methylator phenotype-high colorectal cancers? PMID: 26520418 Ref: CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer. PMID: 26551082 Ref: Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer. PMID: 26775891 Ref: CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. PMID: 26789870 Ref: Cytokeratin 7-positive/cytokeratin 20-negative cecal adenocarcinoma metastatic to the uterine cervix: a case report. PMID: 26810414 Ref: Identifying cancer origin using circulating tumor cells. PMID: 26828696 Ref: CDX2: Linking Cell and Patient Fates in Colon Cancer. PMID: 26849302 Ref: Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. PMID: 26902420 Ref: Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-beta-catenin axis. PMID: 26910375 Ref: Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma. PMID: 27060927 Ref: Immunohistochemical staining for p16 and BRAFV600E is useful to distinguish between sporadic and hereditary (Lynch syndrome-related) microsatellite instable colorectal carcinomas. PMID: 27220764 Ref: CDX2 as a Prognostic Biomarker in Colon Cancer. PMID: 27248627 Ref: CDX2 as a Prognostic Biomarker in Colon Cancer. PMID: 27248628 Ref: CDX2 as a Prognostic Biomarker in Colon Cancer. PMID: 27248629 Ref: CDX2 as a Prognostic Biomarker in Colon Cancer. PMID: 27248630 Ref: Lack of interferon-gamma receptor results in a microenvironment favorable for intestinal tumorigenesis. PMID: 27286456 Ref: Synchronous ovarian metastasis from colorectal cancer: A report of two cases. PMID: 27347134 Ref: SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer. PMID: 27411517 Ref: Intrabiliary Hepatic Metastasis of Colorectal Carcinoma Mimicking Primary Cholangiocarcinoma: A Case Report and Review of the Literature. PMID: 27429820 Ref: Ubiquitin Ligase, Fbw7, Targets CDX2 for Degradation via Two Phosphodegron Motifs in a GSK3beta-Dependent Manner. PMID: 27470268 Ref: Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. PMID: 27504909 Ref: [Pathogenetic aspects in precursor lesions of gastrointestinal tumors]. PMID: 27638535 Ref: Impact of homeobox genes in gastrointestinal cancer. PMID: 27729732 Ref: Methylation of CDX2 as a Predictor in Poor Clinical Outcome of Patients with Colorectal Cancer. PMID: 27754705 Ref: A case report of chylous ascites after gastric bypass for morbid obesity. PMID: 27846453 Ref: Methylation of promoter region of CDX2 gene in colorectal cancer. PMID: 27899987 Ref: [Right Hemi-Colectomy for a Metastatic Transverse Colon Tumor from Breast Cancer Following Bilateral Breast Cancer Resection - A Case Report]. PMID: 28133217 |
Ref: Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry. PMID: 27459899 Ref: Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma. PMID: 27713423 Ref: Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas. PMID: 27813511 Ref: The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton. PMID: 27816490 Ref: Ketogenesis contributes to intestinal cell differentiation. PMID: 27935584 Ref: BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. PMID: 28072391 Ref: Construction and analysis of tissue microarrays in the era of digital pathology: a pilot study targeting CDX1 and CDX2 in a colon cancer cohort of 612 patients. PMID: 28138402 Ref: Pancreatic Metastasis from Rectal Cancer that was Diagnosed by Endoscopic Ultrasonography-guided Fine Needle Aspiration (EUS-FNA). PMID: 28154274 Ref: A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma. PMID: 28226180 Ref: CDX2 prognostic value in stage II/III resected colon cancer is related to CMS classification. PMID: 28328000 Ref: Detection of Free Cancer Cells in Pelvic Lavage with Double Immunocytochemistry at Rectal Cancer Surgery. PMID: 28373415 Ref: Aspirin Use and Colorectal Cancer Survival According to Tumor CD274 (Programmed Cell Death 1 Ligand 1) Expression Status. PMID: 28406723 Ref: Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report. PMID: 28494767 Ref: What We Know About Stage II and III Colon Cancer: It's Still Not Enough. PMID: 28504299 Ref: Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes. PMID: 28572005 Ref: A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis. PMID: 28628609 Ref: Resection of rectal cancer resembling submucosal tumor that was preoperatively diagnosed with endoscopic ultrasound-guided biopsy. PMID: 28748455 Ref: Are All Mutations the Same? A Rare Case Report of Coexisting Mutually Exclusive KRAS and BRAF Mutations in a Patient with Metastatic Colon Adenocarcinoma. PMID: 28811946 Ref: [Personalized Treatment for Colorectal Carcinomas]. PMID: 29078210 Ref: Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression. PMID: 29085667 Ref: Pulmonary metastasectomy for colorectal cancer: analysis of prognostic factors affecting survival. PMID: 29119016 Ref: SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells. PMID: 29155818 Ref: Endometrioid adenocarcinoma arising from colon endometriosis. PMID: 29238580 Ref: Simple classifiers for molecular subtypes of colorectal cancer. PMID: 29241727 Ref: Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer. PMID: 29281831 Ref: Long-term survival in a patient with advanced gastric cancer and metachronous right-sided colon cancer. PMID: 29556659 |
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