Primary Site >> Colorectal Cancer
Gene >> CDX1
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Ref: Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. PMID: 9036867 Ref: Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. PMID: 9126347 |
Ref: Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. PMID: 9593754 |
Ref: Overexpression of Cdx1 and Cdx2 homeogenes enhances expression of the HLA-I in HT-29 cells. PMID: 10964750 |
Ref: CDX-1 and CDX-2 are expressed in human colonic mucosa and are down-regulated in patients with Hirschsprung's disease associated enterocolitis. PMID: 11566252 |
Ref: The caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells. PMID: 11743638 Ref: Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein. PMID: 11997022 Ref: Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. PMID: 12117877 Ref: DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. PMID: 12124393 |
Ref: Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. PMID: 12855703 Ref: Cdx1 homeobox gene during human colon cancer progression. PMID: 12970739 Ref: Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. PMID: 14508520 |
Ref: Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. PMID: 14704280 Ref: Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. PMID: 15215241 Ref: CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation. PMID: 15378566 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. PMID: 15774940 Ref: Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. PMID: 16491830 |
Ref: Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer. PMID: 16510433 Ref: Cancer genetics: colorectal cancer as a model. PMID: 16596323 |
Ref: Cytostatic drug treatment causes seeding of gene promoter methylation. PMID: 17236756 |
Ref: Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. PMID: 18187048 Ref: Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. PMID: 18372917 Ref: Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2. PMID: 18819935 |
Ref: Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. PMID: 19188603 Ref: Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2. PMID: 19781065 |
Ref: CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. PMID: 19900445 Ref: Cancer stem cells from colorectal cancer-derived cell lines. PMID: 20133591 |
Ref: Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. PMID: 21368208 Ref: Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer. PMID: 21393996 |
Ref: Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells. PMID: 22719836 |
Ref: Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells. PMID: 23618814 Ref: Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells. PMID: 23624503 Ref: Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors. PMID: 23867471 |
Ref: Transcriptional control of the B3GALT5 gene by a retroviral promoter and methylation of distant regulatory elements. PMID: 24128890 Ref: Cdx1 and Cdx2 function as tumor suppressors. PMID: 25320087 Ref: Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PMID: 25423035 |
Ref: The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation. PMID: 25775580 Ref: Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. PMID: 25939752 |
Ref: N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression. PMID: 26537799 Ref: [Pathogenetic aspects in precursor lesions of gastrointestinal tumors]. PMID: 27638535 Ref: Impact of homeobox genes in gastrointestinal cancer. PMID: 27729732 |
Ref: Construction and analysis of tissue microarrays in the era of digital pathology: a pilot study targeting CDX1 and CDX2 in a colon cancer cohort of 612 patients. PMID: 28138402 Ref: A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma. PMID: 28226180 |