Primary Site >> Liver Cancer
Gene >> CDKN2A
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Ref: Hepatocarcinogenesis in rodents and humans. PMID: 7559729 Ref: 5'-Deoxy-5'-methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines. PMID: 7898924 |
Ref: Allelotype analysis in mouse hepatocellular carcinomas; frequent homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in culture. PMID: 8741575 Ref: Infrequent alterations of the p16INK4A gene in liver cancer. PMID: 8760583 Ref: Inactivation of p16INK4 in hepatocellular carcinoma. PMID: 8781327 Ref: Homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in mouse liver epithelial cells in culture. PMID: 8924897 Ref: Alterations of CDKN2(p16/MTS1) exon 2 in human hepatocellular carcinoma. PMID: 21594383 |
Ref: Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. PMID: 9049204 Ref: Restriction landmark genomic scanning (RLGS-M)-based genome-wide scanning of mouse liver tumors for alterations in DNA methylation status. PMID: 9242463 Ref: Alteration of cell cycle-related genes in hepatocarcinogenesis. PMID: 9302564 Ref: Molecular mechanism of hepatocarcinogenesis. PMID: 9407351 Ref: Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 gene. PMID: 9439773 |
Ref: Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma. PMID: 9464511 Ref: Mutational study of p16CDKN2/MTS1/INK4A and p57KIP2 genes in hepatocellular carcinoma. PMID: 9472096 Ref: Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. PMID: 9537438 Ref: Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene. PMID: 9667743 Ref: Accumulation of genetic alterations and their significance in each primary human cancer and cell line. PMID: 9685701 Ref: Alteration of the CDKN2A gene in pancreatic cancers: Is it a late event in the progression of pancreatic cancer? PMID: 9735394 Ref: Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers. PMID: 9873831 Ref: Infrequent mutations and no methylation of CDKN2A (P16/MTS1) and CDKN2B (p15/MTS2) in hepatocellular carcinoma in Taiwan. PMID: 9893670 Ref: Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness. PMID: 10374394 |
Ref: Frequent allelic loss on chromosome 9 in hepatocellular carcinoma. PMID: 10209942 Ref: Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. PMID: 10499618 Ref: [The correlation between integration of HBV X, S, Pre-S, C gene and the expression of oncogenes/tumor suppressor genes in primary hepatocellular carcinoma]. PMID: 10572677 Ref: CDKN2 mutation is infrequent in german hepatocellular carcinoma. PMID: 10575317 Ref: Effect of HCV infection on expression of several cancer-associated gene products in HCC. PMID: 11819378 |
Ref: Alterations of P19ARF in rodent hepatoma cell lines but not in human primary liver cancer. PMID: 10704681 Ref: A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5. PMID: 10719366 Ref: Amino acid substitutions in codons 9-11 of hepatitis C virus core protein lead to the synthesis of a short core protein product. PMID: 10735543 Ref: p16 is a major inactivation target in hepatocellular carcinoma. PMID: 10897001 Ref: p16INK4 gene mutation and allelic loss of chromosome 9p21-22 in Taiwanese hepatocellular carcinoma. PMID: 10928081 Ref: Genetics of hepatocellular carcinoma. PMID: 10936068 Ref: P53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells. PMID: 10952243 Ref: Frequent p15 promoter methylation in tumor and peripheral blood from hepatocellular carcinoma patients. PMID: 10999738 Ref: Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patie PMID: 11050047 Ref: 5-Aza-2'-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular carcinoma cell lines. PMID: 11098088 Ref: Abrogation of the p16-Rb pathway in Korean hepatocellular carcinomas. PMID: 11149028 Ref: Genetic aberration in primary hepatocellular carcinoma: correlation between p53 gene mutation and loss-of-heterozygosity on chromosome 16q21-q23 and 9p21-p23. PMID: 11191353 Ref: Molecular and immunohistochemical study of the inactivation of the p16 gene in primary hepatocellular carcinoma. PMID: 11775834 Ref: Deletion of chromosomes 9p and 17 associated with abnormal expression of p53, p16/MTS1 and p15/MTS2 gene protein in hepatocellular carcinomas. PMID: 11776078 Ref: [A study on the inactivation of p16 genes and the expression of P16 protein in primary hepatocellular carcinomas]. PMID: 12545816 |
Ref: Detection of hypermethylation of the p16(INK4A) gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus. PMID: 11171828 Ref: Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. PMID: 11230735 Ref: Frequent k- ras -2 mutations and p16(INK4A)methylation in hepatocellular carcinomas in workers exposed to vinyl chloride. PMID: 11286481 Ref: Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16(INK4A) exon 1 in hepatocellular carci PMID: 11301474 Ref: Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. PMID: 11408803 Ref: Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells. PMID: 11444823 Ref: Expression of the G1-S modulators in hepatitis B virus-related hepatocellular carcinoma and dysplastic nodule: association of cyclin D1 and p53 proteins with the progression of hepatocellular carcinoma. PMID: 11511787 Ref: Alterations at the Ink4a locus in transplacentally induced murine lung tumors. PMID: 11595130 Ref: [Correlation of c-myc gene amplification, MTS1/p16 gene alternation, and HBV infection in human hepatocellular carcinoma]. PMID: 11676877 Ref: Telomerase activity and homozygous deletions of the p16 gene in liver metastases of colorectal carcinoma. PMID: 11677769 Ref: INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. PMID: 11704835 Ref: Effect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36. PMID: 11983026 Ref: [Study of deletion and mutation of p16 gene in primary hepatocellular carcinoma]. PMID: 12528528 Ref: [p16 and cyclinD1 protein expression and p16 gene mutation in primary human hepatocellular carcinoma]. PMID: 12536530 |
Ref: Recurrent allelic deletions at mouse chromosomes 4 and 14 in Myc-induced liver tumors. PMID: 11896580 Ref: Cirrhotic livers reveal genetic changes in the MDM2-P14ARF system of cell cycle regulators. PMID: 11953887 Ref: Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas. PMID: 11982701 Ref: DNA methylation and environmental exposures in human hepatocellular carcinoma. PMID: 12011226 Ref: Establishment and characterization of four human pancreatic carcinoma cell lines. Genetic alterations in the TGFBR2 gene but not in the MADH4 gene. PMID: 12037578 Ref: [Genetic detection and clinical applications in patients with hepatocellular carcinoma]. PMID: 12094698 Ref: Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. PMID: 12124333 Ref: Quantification of tumor suppressor mRNA expression by poly-competitive RT-PCR using a TS-IS that contained multiple internal competitors. PMID: 12132590 Ref: [Establishment of human hepatocellular carcinoma cell line with spontaneous pulmonary metastasis through in vivo selection]. PMID: 12133480 Ref: High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma. PMID: 12325038 Ref: Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. PMID: 12433278 Ref: Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fischer 344 male rats. PMID: 12470904 Ref: Recurrence and metastasis of hepatocellular carcinoma: progress and prospects. PMID: 14607620 |
Ref: Effects of p16 gene on biological behaviours in hepatocellular carcinoma cells. PMID: 12508357 Ref: [Influence of p16 gene on the biological behavior of human hepatocellular carcinoma]. PMID: 12561435 Ref: p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis. PMID: 12565176 Ref: Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma. PMID: 12660822 Ref: Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. PMID: 12668978 Ref: Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats [Mechanisms of Ageing and Development 123 (2002) 1665-1680]. PMID: 12825548 Ref: Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival. PMID: 12827550 Ref: [Determination of expression of eight p53-related genes in hepatocellular carcinoma with tissue microarrays]. PMID: 12866955 Ref: [Effect of p16 gene on carcinogenesis of hepatitis B virus related hepatocellular carcinoma]. PMID: 12921565 Ref: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. PMID: 12937151 Ref: Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway. PMID: 12949053 Ref: Clinicopathologic significance of genetic alterations in hepatocellular carcinoma. PMID: 14499690 Ref: Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. PMID: 14507645 Ref: Gene activity associated with cancers treated by surgical oncologists. PMID: 14619604 Ref: Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis. PMID: 14672555 |
Ref: p16INK4A gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy. PMID: 15012776 Ref: Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line. PMID: 15041736 Ref: [The effects of p16 and Rb protein expression and NF-kappaB activity on hepatocarcinogenesis]. PMID: 15059540 Ref: Patterns of methylation profiles as diagnostic markers for multiple hepatocellular carcinomas. PMID: 15074394 Ref: [Impact of p16INK4A and p15INK4B on human hepatocellular carcinoma cell proliferation and apoptosis]. PMID: 15079795 Ref: Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. PMID: 15082532 Ref: P14ARF gene alterations in human hepatocellular carcinoma. PMID: 15095848 Ref: Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas. PMID: 15168247 Ref: Does percutaneous liver biopsy of hepatocellular carcinoma cause hematogenous dissemination? An in vivo study with quantitative assay of circulating tumor DNA using methylation-specific real-time polymerase chain reaction. PMID: 15269029 Ref: Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma. PMID: 15349907 Ref: Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. PMID: 15619210 |
Ref: Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection. PMID: 15661146 Ref: New and unexpected: forkhead meets ARF. PMID: 15661532 Ref: Abnormal expression of JUNB gene in hepatocellular carcinoma. PMID: 15706412 Ref: Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. PMID: 15723355 Ref: Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16. PMID: 15796965 Ref: Cell biological evaluation of liver cell carcinoma, dysplasia and adenoma by tissue micro-array analysis. PMID: 16000213 Ref: Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. PMID: 16014626 Ref: Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells. PMID: 16254459 Ref: Methylation-based molecular margin analysis in hepatocellular carcinoma. PMID: 16269133 Ref: Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse. PMID: 16286660 Ref: [Growth inhibition and demethylation by a component of natural drug, CDP, in cancer cell lines]. PMID: 16334566 Ref: Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma. PMID: 16343074 Ref: [Laboratory on a microfluidic chip]. PMID: 16350786 Ref: Recent developments in the first detection of hepatocellular carcinoma. PMID: 16450014 |
Ref: DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. PMID: 15885882 Ref: Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. PMID: 16081515 Ref: Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. PMID: 16391877 Ref: Epigenetic instability and chromosomal instability in hepatocellular carcinoma. PMID: 16565510 Ref: Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells. PMID: 16635496 Ref: Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma. PMID: 16646054 Ref: Review of genetic and epigenetic alterations in hepatocarcinogenesis. PMID: 16706806 Ref: [Correlations of CpG island methylator phenotype and OPCML gene methylation to carcinogenesis of hepatocellular carcinoma]. PMID: 16764763 Ref: [Construction and study of replication-defective adenovirus targeting hepatocarcinoma]. PMID: 16831267 Ref: Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies. PMID: 17016600 Ref: p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis. PMID: 17187177 |
Ref: Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. PMID: 17067715 Ref: PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. PMID: 17130832 Ref: Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. PMID: 17187432 Ref: CpG island methylator phenotype association with elevated serum alpha-fetoprotein level in hepatocellular carcinoma. PMID: 17289889 Ref: [Research on promoter region methylation status of tumor repressor gene P16 in human hepatocellular carcinoma by using methylation sensitive restriction enzyme and semi-nested PCR assay]. PMID: 17294727 Ref: Epigenetic defects of hepatocellular carcinoma are already found in non-neoplastic liver cells from patients with hereditary haemochromatosis. PMID: 17412760 Ref: Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. PMID: 17438096 Ref: DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. PMID: 17549390 Ref: Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. PMID: 17584191 Ref: [Chronic hepatitis B virus infection and the methylation status of p16INK4A promoter]. PMID: 17649629 Ref: Rapid identification of promoter hypermethylation in hepatocellular carcinoma by pyrosequencing of etiologically homogeneous sample pools. PMID: 17690210 Ref: Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. PMID: 17699762 Ref: Detection of promoter hypermethylation in serum samples of cancer patients by methylation-specific polymerase chain reaction for tumour suppressor genes including RUNX3. PMID: 17914577 Ref: Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. PMID: 17968429 Ref: Molecular pathways and related target therapies in liver carcinoma. PMID: 18045179 Ref: Telomere length in hepatocellular carcinoma and paired adjacent non-tumor tissues by quantitative PCR. PMID: 18058461 Ref: Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice. PMID: 18069768 Ref: Anticancer effects of aloe-emodin on HepG2 cells: Cellular and proteomic studies. PMID: 21136693 |
Ref: Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. PMID: 18003605 Ref: Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation. PMID: 18004740 Ref: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. PMID: 18161048 Ref: p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. PMID: 18199542 Ref: Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. PMID: 18264082 Ref: Somatostatin receptor in human hepatocellular carcinomas: biological, patient and tumor characteristics. PMID: 18292657 Ref: Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma. PMID: 18350604 Ref: Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver. PMID: 18351580 Ref: CpG island methylator phenotype association with upregulated telomerase activity in hepatocellular carcinoma. PMID: 18546260 Ref: Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. PMID: 18632756 Ref: The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. PMID: 18829528 Ref: [Detection of methylation in hepatocellular carcinoma using SYBR Green fluorescent quantitative PCR]. PMID: 18841566 Ref: Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest. PMID: 18989579 Ref: c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1. PMID: 19009649 Ref: Biological characteristics of fluorescent protein-expressing human hepatocellular carcinoma xenograft model in nude mice. PMID: 19047839 Ref: [Aberrant methylation of multiple genes and its clinical implication in hepatocellular carcinoma]. PMID: 19173828 |
Ref: Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis. PMID: 19016326 Ref: Changes in gene expression and assessment of DNA methylation in primary human hepatocytes and HepG2 cells exposed to the environmental contaminants-Hexabromocyclododecane and 17-beta oestradiol. PMID: 19027819 Ref: Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma. PMID: 19081673 Ref: Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas. PMID: 19136926 Ref: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. PMID: 19447220 Ref: Varying etiologies lead to different molecular changes in Australian and South African hepatocellular carcinomas. PMID: 19787262 Ref: Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis. PMID: 19934271 Ref: Methylation profiling of tumor suppressor genes and oncogenes in hepatitis virus-related hepatocellular carcinoma in northern India. PMID: 19963110 Ref: Molecular mechanisms underlying hepatocellular carcinoma. PMID: 21994573 |
Ref: Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis. PMID: 19732323 Ref: Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients. PMID: 19818350 Ref: DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection. PMID: 20079733 Ref: CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma. PMID: 20112070 Ref: Molecular genetics of hepatocellular neoplasia. PMID: 20182587 Ref: Genomic and immunophenotypical differences between hepatocellular carcinoma with and without cirrhosis. PMID: 20546333 Ref: Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma. PMID: 20569442 Ref: Long-term ethanol exposure causes human liver cancer cells to become resistant to mitomycin C treatment through the inactivation of bad-mediated apoptosis. PMID: 20623640 Ref: Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice. PMID: 20648475 Ref: Predictive value of CpG island methylator phenotype for tumor recurrence in hepatitis B virus-associated hepatocellular carcinoma following liver transplantation. PMID: 20678188 Ref: Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. PMID: 20736025 Ref: [HCV DF protein inhibits expression of p16 and p21 in HepG(2) cells]. PMID: 20815982 Ref: Genetic and epigenetic characteristics of human multiple hepatocellular carcinoma. PMID: 20923573 |
Ref: P16 reactivation induces anoikis and exhibits antitumour potency by downregulating Akt/survivin signalling in hepatocellular carcinoma cells. PMID: 20971978 Ref: Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. PMID: 21145824 Ref: Mysterious link between iron overload and CDKN2A/2B. PMID: 21297911 Ref: Oncosuppressor methylation: a possible key role in colon metastatic progression. PMID: 21506124 Ref: [Effect of RhoC on hepatocellular carcinoma cell growth and related molecular mechanisms]. PMID: 21575497 Ref: Quantitative methylation analysis of multiple genes using methylation-sensitive restriction enzyme-based quantitative PCR for the detection of hepatocellular carcinoma. PMID: 21600201 Ref: Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. PMID: 21684245 Ref: Pokemon reduces Bcl-2 expression through NF-kappa Bp65: A possible mechanism of hepatocellular carcinoma. PMID: 21771706 Ref: P16 gene hypermethylation and hepatocellular carcinoma: a systematic review and meta-analysis. PMID: 21799651 Ref: Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation. PMID: 22014102 Ref: Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins. PMID: 22132221 |
Ref: The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells. PMID: 21674277 Ref: KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis. PMID: 22056911 Ref: Quantitative methylation analysis reveals gender and age differences in p16INK4a hypermethylation in hepatitis B virus-related hepatocellular carcinoma. PMID: 22192146 Ref: Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. PMID: 22407776 Ref: Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer. PMID: 22583549 Ref: Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis. PMID: 22610480 Ref: CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma. PMID: 22705236 Ref: Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation. PMID: 22969091 Ref: Liver Yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells. PMID: 22969849 Ref: Bmi1 is required for hepatic progenitor cell expansion and liver tumor development. PMID: 23029524 Ref: [Hepatitis B virus X protein induces malignant transformation tendency of Chang liver cells involving p16(INK4a) hypermethylation]. PMID: 23247461 |
Ref: Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice. PMID: 22859216 Ref: Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells. PMID: 22986536 Ref: Overexpression of MMSET is correlation with poor prognosis in hepatocellular carcinoma. PMID: 23225158 Ref: Genetics and epigenetics of liver cancer. PMID: 23392071 Ref: Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PMID: 23437062 Ref: Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-beta2 expression via DNA methylation. PMID: 23474497 Ref: Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma. PMID: 23505090 Ref: Genome-wide transcriptional reorganization associated with senescence-to-immortality switch during human hepatocellular carcinogenesis. PMID: 23691139 Ref: Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. PMID: 23853104 Ref: p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. PMID: 23894465 Ref: Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma. PMID: 23943028 Ref: Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways. PMID: 24106286 Ref: [Hepatitis B virus X promotes HepG2 cell cycle progression and growth via downregulation expression of p16 protein]. PMID: 24119743 Ref: Identifying potential cancer driver genes by genomic data integration. PMID: 24346768 Ref: Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. PMID: 24349281 Ref: Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. PMID: 24379610 |
Ref: Proteomic-based analysis for identification of proteins involved in 5-fluorouracil resistance in hepatocellular carcinoma. PMID: 23530500 Ref: Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. PMID: 23888939 Ref: The changing landscape of hepatocellular carcinoma: etiology, genetics, and therapy. PMID: 24388934 Ref: Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs. PMID: 24400091 Ref: Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma. PMID: 24406287 Ref: The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver. PMID: 24452456 Ref: Genomic and transcriptional alterations of cholangiocarcinoma. PMID: 24532422 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: DNA methylation: potential biomarker in Hepatocellular Carcinoma. PMID: 24635883 Ref: Genomic portrait of resectable hepatocellular carcinomas: implications of RB1 and FGF19 aberrations for patient stratification. PMID: 24798001 Ref: The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma. PMID: 24845612 Ref: EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. PMID: 24916103 Ref: Identification of novel therapeutic targets in the PI3K/AKT/mTOR pathway in hepatocellular carcinoma using targeted next generation sequencing. PMID: 24931142 Ref: Aberrant DNA methylation in hepatocellular carcinoma tumor suppression (Review). PMID: 25120642 Ref: DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. PMID: 25190601 Ref: Validation of Bmi1 as a therapeutic target of hepatocellular carcinoma in mice. PMID: 25372945 Ref: COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma. PMID: 25449279 Ref: Methylation of multiple genes in hepatitis C virus associated hepatocellular carcinoma. PMID: 25685469 |
Ref: Epigenetic inactivation of transforming growth factor-beta1 target gene HEYL, a novel tumor suppressor, is involved in the P53-induced apoptotic pathway in hepatocellular carcinoma. PMID: 25179429 Ref: MiR-218-targeting-Bmi-1 mediates the suppressive effect of 1,6,7-trihydroxyxanthone on liver cancer cells. PMID: 25416134 Ref: Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence. PMID: 25482718 Ref: Sirtuin 6 promotes transforming growth factor-beta1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence. PMID: 25683165 Ref: Enoyl-coenzyme A hydratase short chain 1 silencing attenuates the proliferation of hepatocellular carcinoma by inhibiting epidermal growth factor signaling in vitro and in vivo. PMID: 25760819 Ref: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. PMID: 25822088 Ref: Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase. PMID: 25886177 Ref: Analysis of DNA methylation in plasma for monitoring hepatocarcinogenesis. PMID: 25923138 Ref: DNA methylation markers and serum alpha-fetoprotein level are prognostic factors in hepatocellular carcinoma. PMID: 26019036 Ref: Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases. PMID: 26064328 Ref: Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. PMID: 26099527 Ref: Effects of Ras homolog gene family, member C gene silencing combined with rapamycin on hepatocellular carcinoma cell growth. PMID: 26165487 Ref: Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells. PMID: 26165647 Ref: New molecular therapies for hepatocellular carcinoma. PMID: 26206572 Ref: Hepatitis B virus X protein induces the histone H3 lysine 9 trimethylation on the promoter of p16 gene in hepatocarcinogenesis. PMID: 26341139 Ref: HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma. PMID: 26393879 Ref: CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. PMID: 26508638 Ref: Detecting abnormal methylation of tumor suppressor genes GSTP1, P16, RIZ1, and RASSF1A in hepatocellular carcinoma and its clinical significance. PMID: 26622888 Ref: Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma. PMID: 26693075 |
Ref: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. PMID: 26553052 Ref: Aspartate beta-hydroxylase modulates cellular senescence through glycogen synthase kinase 3beta in hepatocellular carcinoma. PMID: 26683595 Ref: Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma. PMID: 26756996 Ref: Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease. PMID: 26875698 Ref: Genome-wide DNA methylation analysis in hepatocellular carcinoma. PMID: 26883180 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations. PMID: 27009864 Ref: Anti-tumor effects of bemiparin in HepG2 and MIA PaCa-2 cells. PMID: 27048831 Ref: Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. PMID: 27064257 Ref: Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. PMID: 27098147 Ref: Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. PMID: 27646854 Ref: The herbal medicine Cyperus amuricus inhibits proliferation of human hepatocellular carcinoma Hep3B cells by inducing apoptosis and arrest at the G0/G1 cell cycle phase. PMID: 27667556 Ref: PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma. PMID: 27708221 Ref: SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. PMID: 27737960 Ref: SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC. PMID: 27824900 Ref: Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma. PMID: 27835605 Ref: Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis. PMID: 27863477 Ref: Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer. PMID: 27880900 |
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