Primary Site >> Colorectal Cancer
Gene >> CDKN1B
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. PMID: 9177226 Ref: Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas. PMID: 9310133 Ref: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. PMID: 9354447 Ref: Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. PMID: 10068276 |
Ref: Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. PMID: 9426067 Ref: gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. PMID: 9683802 Ref: Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of HT29 human colon carcinoma cells. PMID: 9688315 Ref: Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is an indicator of malignant behavior in oral squamous cell carcinoma. PMID: 9874448 |
Ref: Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. PMID: 9926925 Ref: Absence of the cell cycle inhibitor p27Kip1 protein predicts poor outcome in patients with stage I-III colorectal cancer. PMID: 10030411 Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: Paradoxical correlations of cyclin-dependent kinase inhibitors p21waf1/cip1 and p27kip1 in metastatic colorectal carcinoma. PMID: 10353738 Ref: Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers. PMID: 10397272 Ref: Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization. PMID: 10398135 Ref: Levels of expression of p27KIP1 protein in human prostate and prostate cancer: an immunohistochemical analysis. PMID: 10463475 Ref: Reduced expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27(Kip1) in human colon cancer. PMID: 10559792 Ref: The role for transforming growth factor-beta (TGF-beta) in human cancer. PMID: 10654929 Ref: G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation. PMID: 10665655 Ref: Expression of cell-cycle-regulating transcription factor E2F-1 in colorectal carcinomas. PMID: 10738178 Ref: p27(kipl) protein expression: an independent prognostic factor in rectal carcinoma stages I-III. PMID: 23574593 |
Ref: Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. PMID: 10783304 Ref: Induction of apoptosis in human gastric cancer by sodium butyrate. PMID: 10810354 Ref: P27KiP1 overexpression inhibits the growth and doxorubicin sensitivity of HT29 human colon cancer cells in vivo. PMID: 10810365 Ref: p27(kip1) expression in rectal cancer correlates with disease-free survival. PMID: 10864486 Ref: Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells. PMID: 10914738 Ref: Changes in E2F binding after phenylbutyrate-induced differentiation of Caco-2 colon cancer cells. PMID: 10914745 Ref: Cyclin-dependent kinase inhibitor P27(KIP1) is expressed preferentially in early stages of urothelial carcinoma. PMID: 11018640 Ref: Lovastatin and simvastatin are modulators of the proteasome. PMID: 11084375 Ref: A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. PMID: 11089522 Ref: Expression of p27(Kip1) and bcl-2, cigarette smoking, and colorectal cancer risk. PMID: 23889224 |
Ref: Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. PMID: 11313939 Ref: 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. PMID: 11322770 Ref: Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. PMID: 11335900 Ref: The epidermal growth factor receptor as a target for cancer therapy. PMID: 11350723 Ref: P27kip1 expression is associated with tumor response to preoperative chemoradiotherapy in rectal cancer. PMID: 11352304 Ref: Expression of alpha-catenin in alpha-catenin-deficient cells increases resistance to sphingosine-induced apoptosis. PMID: 11489917 Ref: COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. PMID: 11606477 |
Ref: 5-FU improves p27-related poor prognosis in patients with Astler-Coller B2-C colorectal carcinoma. PMID: 11748451 Ref: ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. PMID: 11779200 Ref: Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines. PMID: 11823594 Ref: Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. PMID: 11884591 Ref: Insulin-like growth factor-I has a biphasic effect on colon carcinoma cells through transient inactivation of forkhead1, initially mitogenic, then mediating growth arrest and differentiation. PMID: 11920634 Ref: Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. PMID: 11922774 Ref: p21, p27, cyclin D1, and p53 in rectal cancer: immunohistology with prognostic significance? PMID: 12018448 Ref: High apoptotic activity and low epithelial cell proliferation with underexpression of p21(WAF1/CIP1) and p27Kip1 of mucinous carcinomas of the colorectum: comparison with well-differentiated type. PMID: 12047142 Ref: Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice. PMID: 12086850 Ref: Resveratrol enhances the differentiation induced by butyrate in caco-2 colon cancer cells. PMID: 12097697 Ref: Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. PMID: 12124333 Ref: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. PMID: 12244568 Ref: Cyclin A correlates with carcinogenesis and metastasis, and p27(kip1) correlates with lymphatic invasion, in colorectal neoplasms. PMID: 12395374 Ref: Prognostic significance of p21 and p27 protein, apoptosis, clinical and histologic factors in rectal cancer without lymph node metastases. PMID: 12403937 |
Ref: Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants. PMID: 12455049 Ref: Proliferation of cancer cells despite CDK2 inhibition. PMID: 12676582 Ref: 5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells. PMID: 12692863 Ref: Prognostic significance of p27/kip1 and apoptosis in patients with colorectal carcinoma. PMID: 12792730 Ref: In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. PMID: 12794767 Ref: A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. PMID: 12855618 Ref: Different apoptotic activity and p21(WAF1/CIP1), but not p27(Kip1), expression in serrated adenomas as compared with traditional adenomas and hyperplastic polyps of the colorectum. PMID: 12884030 Ref: P27 does not predict histopathological response to radiochemotherapy in rectal cancer. PMID: 12957127 Ref: High p27Kip1 expression predicts superior relapse-free and overall survival for premenopausal women with early-stage breast cancer receiving adjuvant treatment with tamoxifen plus goserelin. PMID: 14512390 Ref: Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. PMID: 14567460 Ref: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. PMID: 14614451 Ref: Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. PMID: 14690795 |
Ref: Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. PMID: 15041464 Ref: Immunohistochemical expression of cyclin D1, cyclin E, p21/waf1 and p27/kip1 in inflammatory bowel disease: correlation with other cell-cycle-related proteins (Rb, p53, ki-67 and PCNA) and clinicopathological features. PMID: 15060836 Ref: Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. PMID: 15073847 Ref: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines. PMID: 15204521 Ref: Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. PMID: 15342386 Ref: Cell cycle-related signaling pathways modulated by peripheral benzodiazepine receptor ligands in colorectal cancer cells. PMID: 15474510 Ref: Colonic crypt changes during adenoma development in familial adenomatous polyposis: immunohistochemical evidence for expansion of the crypt base cell population. PMID: 15509520 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 |
Ref: Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. PMID: 15584024 Ref: Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines. PMID: 15642413 Ref: The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. PMID: 15717322 Ref: The clinical significance of p53, p21, and p27 expressions in rectal carcinoma. PMID: 15722792 Ref: Prognostic significance of DCC and p27Kip1 in colorectal cancer. PMID: 15722793 Ref: Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation. PMID: 15763423 Ref: Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. PMID: 15793302 Ref: HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. PMID: 15899817 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway. PMID: 15951157 Ref: Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. PMID: 16002406 Ref: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. PMID: 16192633 Ref: Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis. PMID: 16211236 Ref: Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells. PMID: 16224795 Ref: Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1. PMID: 16236452 Ref: Dietary components modify gene expression: implications for carcinogenesis. PMID: 16251635 |
Ref: Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. PMID: 16108056 Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 Ref: Truncated APC is required for cell proliferation and DNA replication. PMID: 16450383 Ref: Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. PMID: 16518840 Ref: The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer. PMID: 16525652 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis. PMID: 16619040 Ref: Prognostic role of p27Kip1 deregulation in colorectal cancer. PMID: 16826582 Ref: Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer. PMID: 16966613 Ref: [4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines. PMID: 16970401 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients. PMID: 17072952 Ref: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells. PMID: 17143939 Ref: Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. PMID: 17178856 |
Ref: Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. PMID: 17086168 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: In vitro differentiation of HT-29 M6 mucus-secreting colon cancer cells involves a trychostatin A and p27(KIP1)-inducible transcriptional program of gene expression. PMID: 17311291 Ref: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. PMID: 17486059 Ref: Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. PMID: 17545604 Ref: Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition. PMID: 17699782 Ref: Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. PMID: 17784872 Ref: Survival stratification panel of colorectal carcinoma with combined expression of carcinoembryonic antigen, matrix metalloproteinases-2, and p27 kip1. PMID: 17882488 Ref: Colorectal cancer or colon and rectal cancer? Clinicopathological comparison between colonic and rectal carcinomas. PMID: 18334831 |
Ref: BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. PMID: 18098337 Ref: Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. PMID: 18172863 Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 Ref: p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells. PMID: 18408738 Ref: Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. PMID: 18414391 Ref: Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer. PMID: 18451165 Ref: Mucronulatol from Caribbean propolis exerts cytotoxic effects on human tumor cell lines. PMID: 18538108 Ref: Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. PMID: 18550571 Ref: Activation of protein kinase G Increases the expression of p21CIP1, p27KIP1, and histidine triad protein 1 through Sp1. PMID: 18593937 Ref: A critical role for Apc in hematopoietic stem and progenitor cell survival. PMID: 18725524 Ref: Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480. PMID: 18855981 Ref: Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features. PMID: 19143860 |
Ref: N6-isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1. PMID: 19058178 Ref: p27Kip1 is inactivated in human colorectal cancer by cytoplasmic localization associated with activation of Akt/PKB. PMID: 19082479 Ref: Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. PMID: 19258012 Ref: p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803. PMID: 19276255 Ref: Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells. PMID: 19290007 Ref: RNA interference-mediated knockdown of p21(WAF1) enhances anti-tumor cell activity of oncolytic adenoviruses. PMID: 19407849 Ref: A cohort study of p27 localization in colon cancer, body mass index, and patient survival. PMID: 19505918 Ref: Mirk regulates the exit of colon cancer cells from quiescence. PMID: 19542220 Ref: A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases. PMID: 19549773 Ref: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. PMID: 19562678 Ref: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. PMID: 19602591 Ref: Schlafen-3: a novel regulator of intestinal differentiation. PMID: 19703412 Ref: Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma. PMID: 19824059 Ref: Depletion of PI3K p85alpha induces cell cycle arrest and apoptosis in colorectal cancer cells. PMID: 19885597 Ref: Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling. PMID: 20196786 |
Ref: RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer. PMID: 19686745 Ref: High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells. PMID: 20181064 Ref: STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells. PMID: 20407011 Ref: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. PMID: 20630104 Ref: Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations. PMID: 20673328 Ref: Significance of p27 as potential biomarker for intracellular oxidative status. PMID: 21103079 |
Ref: Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia camphorate. PMID: 19293251 Ref: Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. PMID: 20473920 Ref: Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells. PMID: 20532678 Ref: Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. PMID: 21061267 Ref: Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. PMID: 21109589 Ref: Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells. PMID: 21109980 Ref: Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. PMID: 21224344 Ref: Cetuximab enhances the activities of irinotecan on gastric cancer cell lines through downregulating the EGFR pathway upregulated by irinotecan. PMID: 21286718 Ref: A novel case of rhabdoid colon carcinoma associated with a positive CpG island methylator phenotype and BRAF mutation. PMID: 21315413 Ref: Do young patients with colorectal cancer have a poorer prognosis than old patients? PMID: 21316708 Ref: Modulation of liver X receptor signaling as a prevention and therapy for colon cancer. PMID: 21333456 Ref: Hunk is required for HER2/neu-induced mammary tumorigenesis. PMID: 21393859 Ref: HOXB7 as a prognostic factor and mediator of colorectal cancer progression. PMID: 21474578 Ref: Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. PMID: 21523318 Ref: Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and beta-catenin/Tcf-4 signaling. PMID: 21625458 Ref: Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. PMID: 21639915 |
Ref: B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells. PMID: 22008852 Ref: Stat6 activity-related Th2 cytokine profile and tumor growth advantage of human colorectal cancer cells in vitro and in vivo. PMID: 22108090 Ref: Involvement of the SKP2-p27(KIP1) pathway in suppression of cancer cell proliferation by RECK. PMID: 22158033 Ref: Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. PMID: 22159220 Ref: In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway. PMID: 22429157 Ref: Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. PMID: 22511578 Ref: 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest. PMID: 22719783 Ref: Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer. PMID: 22961879 Ref: Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells. PMID: 22970236 Ref: Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. PMID: 23029137 Ref: The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate PMID: 23361270 |
Ref: miR-574-5p negatively regulates Qki6/7 to impact beta-catenin/Wnt signalling and the development of colorectal cancer. PMID: 22490519 Ref: Antitumor effects of novel compound, guttiferone K, on colon cancer by p21Waf1/Cip1-mediated G(0) /G(1) cell cycle arrest and apoptosis. PMID: 22733377 Ref: SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers. PMID: 23175153 Ref: External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-kB and induces cell cycle arrest and apoptosis in colorectal cancer cells. PMID: 23363659 Ref: Differential roles of Hath1, MUC2 and P27Kip1 in relation with gamma-secretase inhibition in human colonic carcinomas: a translational study. PMID: 23409082 Ref: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo. PMID: 23448150 Ref: Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression. PMID: 23594796 Ref: FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. PMID: 23603907 Ref: Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. PMID: 23629521 Ref: microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. PMID: 23846336 Ref: Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells. PMID: 24060681 |
Ref: MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1. PMID: 24151081 Ref: Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer. PMID: 24346863 Ref: Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway. PMID: 24811221 Ref: [Expression and significance of c-Jun activation domain binding protein 1 in human colorectal carcinoma]. PMID: 24854908 Ref: microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. PMID: 24885920 Ref: Brachyury regulates proliferation of cancer cells via a p27Kip1-dependent pathway. PMID: 25003467 Ref: Deficient HER3 expression in poorly-differentiated colorectal cancer cells enhances gefitinib sensitivity. PMID: 25017791 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 |
Ref: Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress. PMID: 24819444 Ref: Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. PMID: 25058500 Ref: Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells. PMID: 25544127 Ref: microRNA-200b and microRNA-200c promote colorectal cancer cell proliferation via targeting the reversion-inducing cysteine-rich protein with Kazal motifs. PMID: 25826661 Ref: Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRalpha/c-SRC/ERK1/2/NFkappaB/TP53 pathway: in vitro and in vivo studies. PMID: 26056802 Ref: The role of Skp2 and its substrate CDKN1B (p27) in colorectal cancer. PMID: 26114183 Ref: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. PMID: 26132569 Ref: In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats. PMID: 26323483 Ref: Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity. PMID: 26472352 |
Ref: Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy. PMID: 25594310 Ref: Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis. PMID: 25808857 Ref: Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. PMID: 26183715 Ref: The B56gamma3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1. PMID: 26684356 Ref: TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway. PMID: 26701208 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells. PMID: 27089328 Ref: Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. PMID: 27447597 Ref: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways. PMID: 27669982 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 Ref: Analysis of expression of cyclin E, p27kip1 and Ki67 protein in colorectal cancer tissues and its value for diagnosis, treatment and prognosis of disease. PMID: 27981549 |
Ref: Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. PMID: 27862857 Ref: p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes. PMID: 28158851 Ref: CacyBP/SIP promotes the proliferation of colon cancer cells. PMID: 28196083 Ref: Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art. PMID: 28326100 Ref: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells. PMID: 28555064 Ref: Haploinsufficient tumor suppressor genes. PMID: 28680740 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Combination of FGFR4 inhibitor Blu9931 and 5-fluorouracil effects on the biological characteristics of colorectal cancer cells. PMID: 29048661 Ref: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer. PMID: 29113268 |
Ref: Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation. PMID: 29069290 Ref: Alternative NF-kappaB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. PMID: 29973688 Ref: PCBP1 depletion promotes tumorigenesis through attenuation of p27(Kip1) mRNA stability and translation. PMID: 30086790 Ref: Exosome-mediated miR-200b promotes colorectal cancer proliferation upon TGF-beta1 exposure. PMID: 30119180 Ref: Colonic stent-induced mechanical compression may suppress cancer cell proliferation in malignant large bowel obstruction. PMID: 30171397 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. PMID: 30214616 Ref: Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential. PMID: 30220832 |