Primary Site >> Liver Cancer
Gene >> CDKN1A
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Ref: Mutant p53 but not hepatitis B virus X protein is present in hepatitis B virus-related human hepatocellular carcinoma. PMID: 8521397 |
Ref: Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP). PMID: 8761421 Ref: Inhibition of hepatitis-B-virus core promoter by p53: implications for carcinogenesis in hepatocytes. PMID: 8824564 |
Ref: Decreased expression and rare somatic mutation of the CIP1/WAF1 gene in human hepatocellular carcinoma. PMID: 9022146 Ref: [Laminin-dependent growth arrest of human hepatic carcinoma cell line, HuH-7, in association with expression of p21/WAF-1 protein]. PMID: 9128052 Ref: Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line. PMID: 9162071 |
Ref: Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity. PMID: 9524287 Ref: Protein expression of p53, p21WAF1, and Rb as prognostic indicators in patients with surgically treated hepatocellular carcinoma. PMID: 9568177 Ref: p21/WAF1, p53 and PCNA expression and p53 mutation status in hepatocellular carcinoma. PMID: 9699537 Ref: Two new p73 splice variants, gamma and delta, with different transcriptional activity. PMID: 9802988 Ref: Cell cycle regulators and human hepatocarcinogenesis. PMID: 9840120 Ref: Molecular and cellular pathology of hepatocellular carcinoma. PMID: 28976653 |
Ref: Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells. PMID: 10209305 Ref: Transforming growth factor beta targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. PMID: 10611320 Ref: [WAF1/CIP1 gene expression in human hepatocellular carcinoma and its relationship with p53 mutation]. PMID: 10715791 |
Ref: Survivin promotes cell proliferation in human hepatocellular carcinoma. PMID: 10796883 Ref: Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas. PMID: 10883667 Ref: Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells. PMID: 10918595 Ref: Hepatitis C virus core protein enhances p53 function through augmentation of DNA binding affinity and transcriptional ability. PMID: 10924497 Ref: P53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells. PMID: 10952243 Ref: Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21(WAF1) expression and hepatic apoptosis. PMID: 11819597 Ref: Measurement of Protein Expression of p53, p21(WAF1), and Rb in Patients with Surgically Treated Hepatocellular Carcinoma by Using Catalyzed Signal-Amplification System. PMID: 21341055 |
Ref: Correlation between p21(waf1) and p16(INK4a) expression in hepatocellular carcinoma. PMID: 11282486 Ref: Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines. PMID: 11343236 Ref: Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. PMID: 11384995 Ref: Distinctive gene expression profiles associated with Hepatitis B virus x protein. PMID: 11439330 Ref: The cytotoxic effect of E1B 55-kDa mutant adenovirus on human hepatocellular carcinoma cell lines. PMID: 11477453 Ref: Expression of p27(KIP1) and p21(WAF1/CIP1) in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysis. PMID: 11521219 Ref: Enhancement of tumor radioresponse by combined chemotherapy in murine hepatocarcinoma. PMID: 11555102 Ref: Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway. PMID: 11574165 Ref: Exogenous expression of p21(WAF1/CIP1) exerts cell growth inhibition and enhances sensitivity to cisplatin in hepatoma cells. PMID: 11595124 Ref: [The effect of p53 gene on p-glycoprotein expression and chemotherapeutic cytotoxicity of hepatocellular carcinoma]. PMID: 11602059 |
Ref: A cyclin-dependent kinase inhibitor (p21(WAF1/CIP1)) affects thymidine incorporation in human liver cancer cells. PMID: 11870547 Ref: Attenuation of transforming growth factor beta-induced growth inhibition in human hepatocellular carcinoma cell lines by cyclin D1 overexpression. PMID: 11906173 Ref: Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein. PMID: 11997040 Ref: High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. PMID: 12055678 Ref: Effector mechanisms of norcantharidin-induced mitotic arrest and apoptosis in human hepatoma cells. PMID: 12115564 Ref: Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. PMID: 12124333 Ref: Quantification of tumor suppressor mRNA expression by poly-competitive RT-PCR using a TS-IS that contained multiple internal competitors. PMID: 12132590 Ref: Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway. PMID: 12185267 Ref: Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21(WAF1) down-regulation -- effect of transforming growth factor beta. PMID: 12217602 Ref: Effects of tachyplesin on proliferation and differentiation of human hepatocellular carcinoma SMMC-7721 cells. PMID: 12439924 |
Ref: Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice. PMID: 12503075 Ref: Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. PMID: 12643593 Ref: [The role of hepatitis B virus X gene and p53 on hepatocellular carcinoma cell growth]. PMID: 12760803 Ref: Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex. PMID: 12833133 Ref: [Determination of expression of eight p53-related genes in hepatocellular carcinoma with tissue microarrays]. PMID: 12866955 Ref: [Study of cooperation of tumor suppressor p33(ING1b) with p53 gene in hepatocellular carcinoma]. PMID: 14642087 |
Ref: p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells. PMID: 15004518 Ref: Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review). PMID: 15010815 Ref: Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. PMID: 15336447 Ref: [Different sensitivity of inbred mice to hepatocarcinogen ortho-aminoazotoluene may be due to differences in the negative control mechanisms of hepatocyte proliferation]. PMID: 15346788 Ref: Inhibition of p53-mediated transcriptional responses by mithramycin A. PMID: 15489892 Ref: Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. PMID: 15632311 |
Ref: Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model. PMID: 15523682 Ref: The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells. PMID: 15543231 Ref: Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. PMID: 15780071 Ref: Inhibitory effect of tumor suppressor p33(ING1b) and its synergy with p53 gene in hepatocellular carcinoma. PMID: 15800978 Ref: Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. PMID: 15867364 Ref: Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. PMID: 16014626 Ref: EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. PMID: 16226226 Ref: GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation. PMID: 16260267 |
Ref: Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). PMID: 16112786 Ref: Acyclic retinoid, a novel synthetic retinoid, induces growth inhibition, apoptosis, and changes in mRNA expression of cell cycle- and differentiation-related molecules in human colon carcinoma cells. PMID: 16596235 Ref: DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor. PMID: 16818630 Ref: Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. PMID: 16857806 Ref: Integrin beta(1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721. PMID: 16894473 Ref: Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein. PMID: 16937438 Ref: Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21. PMID: 17080297 Ref: [Synergistic inhibitory effect of all-trans retinoic acid and 1,25-dihydroxy vitamin D3 on growth of human hepatoma cell line HepG2]. PMID: 17166369 Ref: Homeostatic response under carcinogen withdrawal, heme oxygenase 1 expression and cell cycle association. PMID: 17169158 |
Ref: Methanol extract of the seaweed Gloiopeltis furcata induces G2/M arrest and inhibits cyclooxygenase-2 activity in human hepatocarcinoma HepG2 cells. PMID: 17078109 Ref: Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells. PMID: 17211849 Ref: Forced expression of RDH10 gene retards growth of HepG2 cells. PMID: 17218779 Ref: In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma. PMID: 17297474 Ref: TIMP-1 mediates the inhibitory effect of interleukin-6 on the proliferation of a hepatocarcinoma cell line in a STAT3-dependent manner. PMID: 17464423 Ref: Hepatocyte senescence in end-stage chronic liver disease: a study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma. PMID: 17498252 Ref: Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). PMID: 17520098 Ref: Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. PMID: 17596875 Ref: P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection. PMID: 17617120 Ref: Induction of p53-regulated gene expression in human cell lines exposed to the cyanobacterial toxin cylindrospermopsin. PMID: 17763087 Ref: Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest. PMID: 18021445 Ref: [Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells]. PMID: 18161303 |
Ref: Reduction of PKC alpha decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. PMID: 17486587 Ref: Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway. PMID: 17574577 Ref: Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation. PMID: 18004740 Ref: Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells. PMID: 18219600 Ref: Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivo. PMID: 18222491 Ref: ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. PMID: 18299943 Ref: A chenodeoxycholic derivative, HS-1200, induces apoptosis and cell cycle modulation via Egr-1 gene expression control on human hepatoma cells. PMID: 18554781 Ref: Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis. PMID: 18794801 Ref: [Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU]. PMID: 18851785 Ref: Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT. PMID: 18925944 Ref: Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate. PMID: 19024104 Ref: [The effect of p21 on transcription of survivin in hepatocellular carcinoma HepG2 cells and its regulation mechanism]. PMID: 19102934 Ref: Antibody Arrays Identify Potential Diagnostic Markers of Hepatocellular Carcinoma. PMID: 19578489 |
Ref: RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma. PMID: 18466352 Ref: Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels. PMID: 19041685 Ref: Asparanin A induces G(2)/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. PMID: 19254688 Ref: Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B. PMID: 19263472 Ref: Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells. PMID: 19343784 Ref: G2-phase arrest through p21(WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells. PMID: 19414386 Ref: Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma. PMID: 19418558 Ref: NORE1A tumor suppressor candidate modulates p21CIP1 via p53. PMID: 19435914 Ref: Down-regulation of the HGF/MET autocrine loop induced by celecoxib and mediated by P-gp in MDR-positive human hepatocellular carcinoma cell line. PMID: 19447220 Ref: Chromosomal instability, telomere shortening, and inactivation of p21(WAF1/CIP1) in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis. PMID: 19465904 Ref: Acyclic retinoid synergises with valproic acid to inhibit growth in human hepatocellular carcinoma cells. PMID: 19520494 Ref: Plk1 regulates liver tumor cell death by phosphorylation of TAp63. PMID: 19668228 Ref: SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis. PMID: 19686743 Ref: Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. PMID: 20025780 |
Ref: Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation. PMID: 19656618 Ref: TGF-beta inactivation and TGF-alpha overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer. PMID: 20020490 Ref: Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness. PMID: 20305690 Ref: Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression. PMID: 20426839 Ref: Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. PMID: 20460749 Ref: Genomic and immunophenotypical differences between hepatocellular carcinoma with and without cirrhosis. PMID: 20546333 Ref: Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells. PMID: 20574925 Ref: MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. PMID: 20827722 Ref: Combined inhibitory effects of celecoxib and fluvastatin on the growth of human hepatocellular carcinoma xenografts in nude mice. PMID: 20926014 Ref: The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression. PMID: 21038417 Ref: [Effects of simvastatin on the proliferation of HepG2 cells]. PMID: 21059291 |
Ref: Clinical significance of miR-221 and its inverse correlation with p27Kip(1) in hepatocellular carcinoma. PMID: 20146005 Ref: Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth. PMID: 21215801 Ref: Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal S-phase arrest in human hepatoma and breast cancer cells. PMID: 21319227 Ref: Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. PMID: 21382167 Ref: Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. PMID: 21607682 Ref: Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. PMID: 21649584 Ref: Involvement of insulin-like growth factor-binding protein-3 in the effects of histone deacetylase inhibitor MS-275 in hepatoma cells. PMID: 21737444 Ref: MicroRNA-423 promotes cell growth and regulates G(1)/S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma. PMID: 21890460 Ref: Possible role of visfatin in hepatoma progression and the effects of branched-chain amino acids on visfatin-induced proliferation in human hepatoma cells. PMID: 21952585 Ref: Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins. PMID: 22132221 Ref: Downregulation and antiproliferative role of FHL3 in breast cancer. PMID: 22362714 |
Ref: Functional analysis of alpha1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells. PMID: 22155250 Ref: Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway. PMID: 22226916 Ref: In hepatocellular carcinoma miR-519d is up-regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2. PMID: 22262409 Ref: Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. PMID: 22342966 Ref: HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. PMID: 22496786 Ref: Synergistic growth inhibition of human hepatocellular carcinoma cells by acyclic retinoid and GW4064, a farnesoid X receptor ligand. PMID: 22579649 Ref: Human ESC self-renewal promoting microRNAs induce epithelial-mesenchymal transition in hepatocytes by controlling the PTEN and TGFbeta tumor suppressor signaling pathways. PMID: 22622027 Ref: N-Benzoyl-12-nitrodehydroabietylamine-7-one, a novel dehydroabietylamine derivative, induces apoptosis and inhibits proliferation in HepG2 cells. PMID: 22743618 Ref: Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a. PMID: 22815774 Ref: Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines. PMID: 22895844 Ref: Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells. PMID: 22909100 Ref: Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. PMID: 22965024 Ref: Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo. PMID: 22993037 Ref: Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. PMID: 23027617 Ref: Hepatic gene expression analysis of 2-aminoanthracene exposed Fisher-344 rats reveal patterns indicative of liver carcinoma and type 2 diabetes. PMID: 23038007 Ref: HDAC inhibitor L-carnitine and proteasome inhibitor bortezomib synergistically exert anti-tumor activity in vitro and in vivo. PMID: 23285100 |
Ref: Genetic variants of p21 and p27 and hepatocellular cancer risk in a Chinese Han population: a case-control study. PMID: 23034899 Ref: Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. PMID: 23079745 Ref: Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction. PMID: 23165705 Ref: Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis. PMID: 23448253 Ref: The molecular mechanism and potential role of heat shock-induced p53 protein accumulation. PMID: 23456460 Ref: Identification of FN1BP1 as a novel cell cycle regulator through modulating G1 checkpoint in human hepatocarcinoma Hep3B cells. PMID: 23469028 Ref: The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice. PMID: 23526443 Ref: Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells. PMID: 23577194 Ref: MicroRNA-22 is down-regulated in hepatitis B virus-related hepatocellular carcinoma. PMID: 23582783 Ref: Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells. PMID: 23596478 Ref: Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells. PMID: 23726867 Ref: Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma. PMID: 24012840 Ref: Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. PMID: 24085778 Ref: Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells. PMID: 24103747 Ref: PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context. PMID: 24336083 Ref: The Inhibitory Effect of 3 beta -Hydroxy-12-oleanen-27-oic Acid on Growth and Motility of Human Hepatoma HepG2 Cells through JNK and Akt Signaling Pathway. PMID: 24379889 |
Ref: 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARgamma-mediated activation of p21WAF1/Cip1. PMID: 23542179 Ref: Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. PMID: 23888939 Ref: p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury. PMID: 24092862 Ref: AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. PMID: 24100703 Ref: Decorin deficiency promotes hepatic carcinogenesis. PMID: 24361483 Ref: Overexpression of the transcription factor MEF2D in hepatocellular carcinoma sustains malignant character by suppressing G2-M transition genes. PMID: 24390737 Ref: Latexin exhibits tumor suppressor potential in hepatocellular carcinoma. PMID: 24399246 Ref: CCR9 as a prognostic marker and therapeutic target in hepatocellular carcinoma. PMID: 24481516 Ref: The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression. PMID: 24509161 Ref: Asiatic acid promotes p21(WAF1/CIP1) protein stability through attenuation of NDR1/2 dependent phosphorylation of p21(WAF1/ CIP1) in HepG2 human hepatoma cells. PMID: 24568526 Ref: Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma. PMID: 24708861 Ref: IL-20 and IL-20R1 antibodies protect against liver fibrosis. PMID: 24763901 Ref: [Activation of p21(WAF1/CIP1) by small activating RNA inhibits cell proliferation and induces apoptosis in BEL-7402 hepatoma cell]. PMID: 25146739 Ref: MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma. PMID: 25280563 Ref: Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. PMID: 25549359 |
Ref: Upregulated expression of miR-106a by DNA hypomethylation plays an oncogenic role in hepatocellular carcinoma. PMID: 25510666 Ref: p21 ablation in liver enhances DNA damage, cholestasis, and carcinogenesis. PMID: 25608711 Ref: MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. PMID: 25633810 Ref: Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells. PMID: 25714018 Ref: MEF2D overexpression contributes to the progression of osteosarcoma. PMID: 25814384 Ref: Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma. PMID: 26165304 Ref: Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2. PMID: 26287415 Ref: Current concepts in pathophysiology and management of hepatocellular carcinoma. PMID: 26345095 Ref: Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma. PMID: 26693075 Ref: Anti-cancer Activity of Osmanthus matsumuranus Extract by Inducing G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma Hep G2 Cells. PMID: 26734586 |
Ref: Influence of selected anti-cancer drugs on the induction of DNA double-strand breaks and changes in gene expression in human hepatoma HepG2 cells. PMID: 26392091 Ref: Transcription factor LSF (TFCP2) inhibits melanoma growth. PMID: 26506241 Ref: 1,25(OH)2D3 inhibits the progression of hepatocellular carcinoma via downregulating HDAC2 and upregulating P21(WAFI/CIP1). PMID: 26676829 Ref: Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver. PMID: 26725321 Ref: Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686. PMID: 26760772 Ref: Long noncoding RNA uc.338 promotes cell proliferation through association with BMI1 in hepatocellular carcinoma. PMID: 27154519 Ref: Electro-hyperthermia up-regulates tumour suppressor Septin 4 to induce apoptotic cell death in hepatocellular carcinoma. PMID: 27269053 Ref: A p53-independent apoptotic mechanism of adenoviral mutant E1A was involved in its selective antitumor activity for human cancer. PMID: 27340782 Ref: Trichloroethylene-Induced DNA Methylation Changes in Male F344 Rat Liver. PMID: 27618143 Ref: Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. PMID: 27646854 Ref: The herbal medicine Cyperus amuricus inhibits proliferation of human hepatocellular carcinoma Hep3B cells by inducing apoptosis and arrest at the G0/G1 cell cycle phase. PMID: 27667556 Ref: Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression. PMID: 27698442 Ref: Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation. PMID: 27832471 Ref: Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway. PMID: 28105167 |
Ref: Delta40p53alpha suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells. PMID: 27980070 Ref: Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells. PMID: 28351032 Ref: Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer. PMID: 28373419 Ref: An investigation of the role of gene copy number variations in sorafenib sensitivity in metastatic hepatocellular carcinoma patients. PMID: 28382134 Ref: The aryl hydrocarbon receptor is required for induction of p21cip1/waf1 expression and growth inhibition by SU5416 in hepatoma cells. PMID: 28424418 Ref: Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells. PMID: 28443465 Ref: HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372. PMID: 28467776 Ref: Dysfunction of IKZF1/MYC/MDIG axis contributes to liver cancer progression through regulating H3K9me3/p21 activity. PMID: 28471446 Ref: Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells. PMID: 28655760 Ref: ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. PMID: 28716731 Ref: Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse. PMID: 28903351 Ref: PANDAR: a pivotal cancer-related long non-coding RNA in human cancers. PMID: 28976505 Ref: TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a. PMID: 29080747 Ref: MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis. PMID: 29179453 Ref: Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma. PMID: 29242565 Ref: Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC. PMID: 29383172 |
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