Primary Site >> Colorectal Cancer
Gene >> CDKN1A
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Ref: Ras oncogene and the acquisition of metastasizing properties by rectal adenocarcinoma. PMID: 2666052 |
Ref: Immunoscintigraphy of human tumors transplanted in nude mice with radiolabeled anti-ras p21 monoclonal antibodies. PMID: 2203882 |
Ref: WAF1, a potential mediator of p53 tumor suppression. PMID: 8242752 Ref: DNA ploidy, c-myc oncoprotein p62 and v-H-ras oncoprotein p21 in colorectal carcinoma. PMID: 8461612 |
Ref: Induction of Fas-mediated apoptosis in p53-transfected human colon carcinoma cells. PMID: 7478511 Ref: Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain. PMID: 7559386 Ref: Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. PMID: 7712469 Ref: Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer. PMID: 7845685 Ref: Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect. PMID: 7890601 |
Ref: DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin. PMID: 8619835 Ref: Repair Defect in p21 WAF1/CIP1 -/- human cancer cells. PMID: 8625293 Ref: An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines. PMID: 8631022 Ref: The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins. PMID: 8632912 Ref: The p53 gene is a potent determinant of chemosensitivity and radiosensitivity in gastric and colorectal cancers. PMID: 8642047 Ref: Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells. PMID: 8668331 Ref: Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma. PMID: 8688317 Ref: Decorin-induced growth suppression is associated with up-regulation of p21, an inhibitor of cyclin-dependent kinases. PMID: 8702560 Ref: Genetic determinants of p53-induced apoptosis and growth arrest. PMID: 8756351 Ref: Reduced messenger RNA expression level of p21 CIP1 in human colorectal carcinoma tissues and its association with p53 gene mutation. PMID: 8797864 Ref: Immunohistochemical detection of p21waf1/cip1/sdi1 and p53 proteins in formalin-fixed, paraffin-embedded tissue sections of colorectal carcinoma. PMID: 8816885 Ref: p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line. PMID: 8831553 Ref: c-Myc inactivation by mutant Max alters growth and morphology of NCI-H-630 colon cancer cells. PMID: 8841436 Ref: Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line. PMID: 8895552 Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines. PMID: 8938795 Ref: Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. PMID: 8943319 Ref: Wild-type p53 demonstrates functional dominance in a human colon carcinoma cell line in which it induces reversible growth arrest. PMID: 9816111 Ref: Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction. PMID: 9816291 |
Ref: WAF1 expression and p53 mutations in human colorectal cancers. PMID: 9030251 Ref: Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. PMID: 9150394 Ref: Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard. PMID: 9174048 Ref: Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases. PMID: 9202067 Ref: Expression of p21WAF1/CIP1 in colorectal adenomas and adenocarcinomas and its correlation with p53 protein expression. PMID: 9234386 Ref: Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. PMID: 9268365 Ref: The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells. PMID: 9343371 Ref: Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. PMID: 9354425 Ref: Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. PMID: 9359698 Ref: Expressions of cell cycle regulators in human colorectal cancer cell lines. PMID: 9369933 Ref: Fiber-derived butyrate and the prevention of colon cancer. PMID: 9384528 Ref: 14-3-3sigma is a p53-regulated inhibitor of G2/M progression. PMID: 9659898 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. PMID: 9467956 Ref: Transcriptional silencing of perlecan gene expression by interferon-gamma. PMID: 9468523 Ref: Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells. PMID: 9488034 Ref: Role of p53 and p21/WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients. PMID: 9510313 Ref: Short-chain fatty acids induce cell cycle inhibitors in colonocytes. PMID: 9558282 Ref: Protein kinase Calpha controls the adhesion but not the antiproliferative response of human colon carcinoma cells to transforming growth factor beta1: identification of two distinct branches of post-protein kinase Calpha adhesion signal pathway. PMID: 9564886 Ref: Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers. PMID: 9607584 Ref: p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. PMID: 9618491 Ref: Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells. PMID: 9661904 Ref: Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas. PMID: 9664127 Ref: Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line. PMID: 9673359 Ref: Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein. PMID: 9677415 Ref: [Molecular effects of vitamin D on cell cycle and oncogenesis]. PMID: 9691832 Ref: [A novel approach for cancer chemoprevention referred to as "gene-regulating chemoprevention"]. PMID: 9695075 Ref: [Messenger RNA expression of p21WAF1/CIP1 in colorectal carcinoma tissues]. PMID: 9742528 Ref: Dexamethasone-mediated protection from drug cytotoxicity: association with p21WAF1/CIP1 protein accumulation? PMID: 9794234 Ref: Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4. PMID: 9814966 Ref: Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. PMID: 9824154 |
Ref: Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. PMID: 9926925 Ref: An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings. PMID: 10022664 Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: Paradoxical correlations of cyclin-dependent kinase inhibitors p21waf1/cip1 and p27kip1 in metastatic colorectal carcinoma. PMID: 10353738 Ref: Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. PMID: 10382266 Ref: Loss of P27Kip1 expression correlates with tumor grade and with reduced disease-free survival in primary superficial bladder cancers. PMID: 10397272 Ref: p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations. PMID: 10398083 Ref: Disruption of p53 in human cancer cells alters the responses to therapeutic agents. PMID: 10430607 Ref: Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene. PMID: 10441517 Ref: p22/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis. PMID: 10487624 Ref: Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. PMID: 10490814 Ref: Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells. PMID: 10559252 Ref: A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses. PMID: 10582770 Ref: Assessment of biomarkers in paired primary and recurrent colorectal adenocarcinomas. PMID: 10613309 Ref: Effect of p53 tumor suppressor on nucleotide excision repair in human colon carcinoma cells treated with 4-nitroquinoline 1-oxide. PMID: 10634308 Ref: G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation. PMID: 10665655 Ref: Cyclooxygenase-independent induction of p21WAF-1/CIP1, apoptosis and differentiation by L-745,337 and salicylate in HT-29 colon cancer cells. PMID: 10667382 Ref: Association of increased radiocurability of murine carcinomas with low constitutive expression of p21(WAF1/CIP1) protein. PMID: 10760438 Ref: p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. PMID: 10935502 |
Ref: Involvement of p21(Waf1/Cip1) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate. PMID: 10607727 Ref: Pyrrolidinedithiocarbamate increases the therapeutic index of 5-fluorouracil in a mouse model. PMID: 10611156 Ref: HuR regulates p21 mRNA stabilization by UV light. PMID: 10629032 Ref: p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression. PMID: 10646868 Ref: Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. PMID: 10657978 Ref: p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. PMID: 10676653 Ref: p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. PMID: 10694497 Ref: Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. PMID: 10706135 Ref: Prognostic impact of p21/waf1/cip1 in colorectal cancer. PMID: 10719725 Ref: Expression of cell cycle control proteins in primary colorectal tumors does not always predict expression in lymph node metastases. PMID: 10741741 Ref: Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. PMID: 10782880 Ref: Induction of apoptosis in human gastric cancer by sodium butyrate. PMID: 10810354 Ref: Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice. PMID: 10815928 Ref: Effect of mutation and conformation on the function of p53 in colorectal cancer. PMID: 10918210 Ref: Phenotypic and molecular characteristics of hyperplastic polyposis. PMID: 10930367 Ref: Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells. PMID: 10959623 Ref: Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative. PMID: 10964085 Ref: Comparative evaluation of the expression of cell cycle regulating proteins: cyclin D1, P53 and P21 (WAF1) in colorectal cancer. PMID: 10974928 Ref: Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: effect of TP53 or hMLH1 deficiency. PMID: 10993958 Ref: Cyclin-dependent kinase inhibitor P27(KIP1) is expressed preferentially in early stages of urothelial carcinoma. PMID: 11018640 Ref: Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells. PMID: 11029587 Ref: Repression of transforming growth factor-beta receptor type I promoter expression by Sp1 deficiency. PMID: 11030155 Ref: p53 gene status and expression of p53, mdm2, and p21Waf1/Cip1 proteins in colorectal cancer. PMID: 11037343 Ref: Apoptosis and its regulation in flat-type early colorectal carcinoma: comparison with that in polypoid-type early colorectal carcinoma. PMID: 11052474 Ref: A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells. PMID: 11055588 Ref: Low dose fractionated radiation enhances the radiosensitization effect of paclitaxel in colorectal tumor cells with mutant p53. PMID: 11064345 Ref: A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. PMID: 11072252 Ref: Roles of nuclear factor-kappaB, p53, and p21/WAF1 in daunomycin-induced cell cycle arrest and apoptosis. PMID: 11082419 Ref: The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design. PMID: 11097346 Ref: TNF-alpha induced p21(WAF1) but not Bax in colon cancer cells WiDr with mutated p53: important role of protein stabilization. PMID: 11097743 Ref: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. PMID: 11132966 Ref: Expression of inducible nitric oxide synthase in colorectal cancer and its association with prognosis. PMID: 11145294 Ref: Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers. PMID: 11150376 Ref: A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth. PMID: 11156415 Ref: 8-Cl-adenosine-induced inhibition of colorectal cancer growth in vitro and in vivo. PMID: 11191111 Ref: Inhibition of X-ray and doxorubicin-induced apoptosis by butyrolactone I, a CDK-specific inhibitor, in human tumor cells. PMID: 11329882 Ref: Change of apoptotic status in the human colorectal adenoma-carcinoma sequences and its correlation with carcinogenesis and prognosis. PMID: 11775833 |
Ref: Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III. PMID: 11029459 Ref: Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells. PMID: 11121239 Ref: Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. PMID: 11212250 Ref: The role of p21(CIP1/WAF1) in growth of epithelial cells exposed to hyperoxia. PMID: 11238001 Ref: Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. PMID: 11245456 Ref: Antiproliferative activity and interactions with cell-cycle related proteins of the organotin compound triethyltin(IV)lupinylsulfide hydrochloride. PMID: 11248220 Ref: RPR-115135, a new non peptidomimetic farnesyltransferase inhibitor, induces G0/G1 arrest only in serum starved cells. PMID: 11251185 Ref: Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells. PMID: 11295047 Ref: IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid. PMID: 11299762 Ref: A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function. PMID: 11313999 Ref: [Expression of p21 WAF1/CIP1 protein in colorectal cancers: study of its relation to p53 mutation and Ki67 antigen expression]. PMID: 11317955 Ref: 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. PMID: 11322770 Ref: 8-Cl-adenosine induces differentiation in LS174T cells. PMID: 11330409 Ref: The p53-regulated cyclin-dependent kinase inhibitor, p21 (cip1, waf1, sdi1), is not required for global genomic and transcription-coupled nucleotide excision repair of UV-induced DNA photoproducts. PMID: 11331289 Ref: Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms. PMID: 11408253 Ref: p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents. PMID: 11423989 Ref: Heterocyclic amine induced apoptotic response in the human lymphoblastoid cell line TK6 is linked to mismatch repair status. PMID: 11425520 Ref: Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21(WAF1/CIP1) expression and correlates with patient survival. PMID: 11494229 Ref: Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. PMID: 11559818 Ref: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. PMID: 11562278 Ref: p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity. PMID: 11568365 Ref: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. PMID: 11574543 Ref: Butyrate-induced differentiation of Caco-2 cells is mediated by vitamin D receptor. PMID: 11676498 Ref: Activation of cyclin E-dependent kinase activity in colorectal cancer. PMID: 11680595 Ref: P21 (WAF1) expression in colorectal cancer: correlation with P53 and cyclin D1 expression, clinicopathological parameters and prognosis. PMID: 11700890 Ref: The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways. PMID: 11705845 Ref: Docosahexaenoic acid regulated genes and transcription factors inducing apoptosis in human colon cancer cells. PMID: 11713597 Ref: Development of colonic neoplasms and expressions of p53 and p21 proteins in experimental colitis of mice induced by dextran sulfate sodium. PMID: 11718223 Ref: p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells. PMID: 11795482 Ref: Cdk1/P34Cdc2 and P21waf expression in colorectal adenomas and carcinomas. PMID: 11876550 Ref: [The role of p21 (wafl/cip1) in human colorectal carcinoma cell apoptosis]. PMID: 16200730 |
Ref: Antiproliferative activity of mixed-ligand dien-Cu(II) complexes with thiazole, thiazoline and imidazole derivatives. PMID: 11750022 Ref: Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. PMID: 11752408 Ref: ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. PMID: 11779200 Ref: Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1. PMID: 11784716 Ref: p53 expression in human rectal tissue after radiotherapy: upregulation in normal mucosa versus functional loss in rectal carcinomas. PMID: 11849795 Ref: Human papillomavirus type 16 E6-enhanced susceptibility to apoptosis induced by TNF in A2780 human ovarian cancer cell line. PMID: 11857347 Ref: Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata. PMID: 11858759 Ref: Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. PMID: 11888673 Ref: SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression. PMID: 11890931 Ref: Human cells deficient in p53 regulated p21(waf1/cip1) expression exhibit normal nucleotide excision repair of UV-induced DNA damage. PMID: 11895854 Ref: Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. PMID: 11895920 Ref: Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. PMID: 11922774 Ref: C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells. PMID: 11961668 Ref: Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. PMID: 11989975 Ref: p21, p27, cyclin D1, and p53 in rectal cancer: immunohistology with prognostic significance? PMID: 12018448 Ref: The p53 stabilizing compound CP-31398 induces apoptosis by activating the intrinsic Bax/mitochondrial/caspase-9 pathway. PMID: 12027451 Ref: 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. PMID: 12036922 Ref: High apoptotic activity and low epithelial cell proliferation with underexpression of p21(WAF1/CIP1) and p27Kip1 of mucinous carcinomas of the colorectum: comparison with well-differentiated type. PMID: 12047142 Ref: Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. PMID: 12082636 Ref: Resveratrol enhances the differentiation induced by butyrate in caco-2 colon cancer cells. PMID: 12097697 Ref: Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. PMID: 12124333 Ref: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. PMID: 12151395 Ref: Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors. PMID: 12154036 Ref: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. PMID: 12174820 Ref: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. PMID: 12175534 Ref: Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb. PMID: 12175902 Ref: Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells. PMID: 12203364 Ref: Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. PMID: 12226108 Ref: Value of expression of p21WAF1/CIP1 as a prognostic factor in advanced middle and lower rectal cancer patients treated with preoperative radio-chemotherapy. PMID: 12239617 Ref: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. PMID: 12244568 Ref: Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). PMID: 12351148 Ref: Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. PMID: 12354803 Ref: 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. PMID: 12359354 Ref: Transcriptional activation of the MUC2 gene by p53. PMID: 12374798 Ref: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. PMID: 12376477 Ref: Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. PMID: 12379237 Ref: UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. PMID: 12384533 Ref: Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. PMID: 12384701 Ref: Prognostic significance of p21 and p27 protein, apoptosis, clinical and histologic factors in rectal cancer without lymph node metastases. PMID: 12403937 Ref: The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. PMID: 12408868 Ref: The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression). PMID: 12429914 Ref: Prognostic values of radiation-induced p53 in adjacent normal mucosa and p21WAF1/CIP1 expression in rectal cancer patients. PMID: 12429971 Ref: Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. PMID: 12464677 Ref: Short chain fatty acids and colon cancer. PMID: 12468628 Ref: Tissue microarray molecular profiling of early, node-negative adenocarcinoma of the rectum: a comprehensive analysis. PMID: 12473598 Ref: Environment-gene interactions in intestinal cancer. PMID: 12570330 Ref: Types and amount of dietary fat and colon cancer risk: Prevention by omega-3 fatty acid-rich diets. PMID: 21432290 |
Ref: Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage. PMID: 12427745 Ref: Rapid turnover of cell-cycle regulators found in Mirk/dyrk1B transfectants. PMID: 12455049 Ref: Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine. PMID: 12473386 Ref: c-myc down-regulation induces apoptosis in human cancer cell lines exposed to RPR-115135 (C31H29NO4), a non-peptidomimetic farnesyltransferase inhibitor. PMID: 12490573 Ref: Ectopic p21sdi1 gene transfer induces retinoic acid receptor beta expression and sensitizes human cancer cells to retinoid treatment. PMID: 12516107 Ref: PUMA mediates the apoptotic response to p53 in colorectal cancer cells. PMID: 12574499 Ref: Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. PMID: 12615711 Ref: Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells. PMID: 12687020 Ref: 5-Fluorouracil efficiently enhanced apoptosis induced by adenovirus-mediated transfer of caspase-8 in DLD-1 colon cancer cells. PMID: 12692863 Ref: A new method for determining the status of p53 in tumor cell lines of different origin. PMID: 12725531 Ref: All trans retinoic acid sensitizes colon cancer cells to hyperthermia cytotoxic effects. PMID: 12792792 Ref: In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest. PMID: 12794767 Ref: [Gene-regulating chemoprevention against cancer--as a model for "molecular-targeting prevention" of cancer]. PMID: 12806965 Ref: Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells. PMID: 12810668 Ref: The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc. PMID: 12816758 Ref: Enhanced sensitivity to cis-diamminedichloroplatinum(II) of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21(WAF1) expression. PMID: 12824923 Ref: Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. PMID: 12847090 Ref: Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. PMID: 12855666 Ref: p21+/+ (CDKN1A+/+) and p21-/- (CDKN1A-/-) human colorectal carcinoma cells display equivalent amounts of thermal radiosensitization. PMID: 12859231 Ref: Molecular modes of action of artesunate in tumor cell lines. PMID: 12869643 Ref: Different apoptotic activity and p21(WAF1/CIP1), but not p27(Kip1), expression in serrated adenomas as compared with traditional adenomas and hyperplastic polyps of the colorectum. PMID: 12884030 Ref: Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. PMID: 12885834 Ref: Down-regulation of proliferating cell nuclear antigen gene expression occurs during cell cycle arrest induced by human fecal water in colonic HT-29 cells. PMID: 12888658 Ref: Short-chain fatty acids and colon cancer cells: the vitamin D receptor--butyrate connection. PMID: 12899527 Ref: p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases. PMID: 12930830 Ref: RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation. PMID: 12944397 Ref: CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. PMID: 12970742 Ref: Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines. PMID: 12970888 Ref: The Kruppel-like transcription factor 6 gene in sporadic pituitary tumours. PMID: 14503916 Ref: Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. PMID: 14567460 Ref: c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. PMID: 14583781 Ref: Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. PMID: 14614330 Ref: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. PMID: 14614451 Ref: Induction of apoptosis by p53, bax, bcl-2, and p21 expressed in colorectal cancer. PMID: 14663636 Ref: Cell cycle dysregulation induced by cytoplasm of Lactococcus lactis ssp lactis in SNUC2A, a colon cancer cell line. PMID: 14690796 |
Ref: Requirement of Kruppel-like factor 4 in preventing entry into mitosis following DNA damage. PMID: 14627709 Ref: Establishment of a colonic adenoma cell line (GEKI-2): spectral karyotype analysis and functional characterization. PMID: 14648095 Ref: Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association. PMID: 14712090 Ref: Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. PMID: 14715079 Ref: 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells. PMID: 14715257 Ref: Identification of Kruppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. PMID: 14724568 Ref: p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid. PMID: 14965371 Ref: Effects of epidermal growth factor and its signal transduction inhibitors on apoptosis in human colorectal cancer cells. 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PMID: 15256118 Ref: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. PMID: 15271980 Ref: Flavone inhibition of tumor growth via apoptosis in vitro and in vivo. PMID: 15289867 Ref: A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. PMID: 15313918 Ref: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). PMID: 15317660 Ref: Computerized video time lapse study of cell cycle delay and arrest, mitotic catastrophe, apoptosis and clonogenic survival in irradiated 14-3-3sigma and CDKN1A (p21) knockout cell lines. PMID: 15332997 Ref: Reduced levels of the adenomatous polyposis coli (APC) protein are associated with ceramide-induced apoptosis of colon cancer cells. PMID: 15340841 Ref: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells. PMID: 15342418 Ref: Cell cycle-related signaling pathways modulated by peripheral benzodiazepine receptor ligands in colorectal cancer cells. PMID: 15474510 Ref: A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function. PMID: 15489172 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 Ref: Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. PMID: 15570007 Ref: Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. PMID: 15572300 Ref: PKCdelta requires p53 for suppression of the transformed phenotype in human colon cancer cells. PMID: 15601585 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 Ref: p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells. PMID: 15665589 Ref: [Effects of celecoxib on the proliferation and apoptosis of human colorectal cancer cell line HT-29]. PMID: 16136956 |
Ref: p21(Waf1/Cip1) and p53 are downstream effectors of protein kinase C delta in tumor suppression and differentiation in human colon cancer cells. PMID: 15386430 Ref: Characterization of the N-methoxyindole-3-carbinol (NI3C)--induced cell cycle arrest in human colon cancer cell lines. PMID: 15483186 Ref: Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. PMID: 15526282 Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. PMID: 15592498 Ref: The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines. PMID: 15655409 Ref: Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. PMID: 15665816 Ref: Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer. PMID: 15716589 Ref: The clinical significance of p53, p21, and p27 expressions in rectal carcinoma. PMID: 15722792 Ref: Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175. PMID: 15726367 Ref: Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53. PMID: 15750621 Ref: The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. PMID: 15767558 Ref: Effect of indomethacin on cell cycle proteins in colon cancer cell lines. PMID: 15786552 Ref: Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice. PMID: 15793302 Ref: Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. PMID: 15860443 Ref: Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1. PMID: 15880444 Ref: Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. PMID: 15891997 Ref: Colon-specific regulation of vitamin D hydroxylases--a possible approach for tumor prevention. PMID: 15905206 Ref: Tangutorine induces p21 expression and abnormal mitosis in human colon cancer HT-29 cells. PMID: 15916751 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. PMID: 15929791 Ref: High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies. PMID: 15930362 Ref: Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells. PMID: 15942645 Ref: ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components. PMID: 15947116 Ref: Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. PMID: 15956247 Ref: Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. PMID: 15958644 Ref: Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway. PMID: 15963949 Ref: Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. PMID: 16002406 Ref: Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane. PMID: 16046710 Ref: Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells. PMID: 16107721 Ref: Radiation response and cell cycle regulation of p53 rescued malignant keratinocytes. PMID: 16120440 Ref: Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells. PMID: 16126233 Ref: The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. PMID: 16160080 Ref: Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer. PMID: 16166444 Ref: Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cancer cells. PMID: 16179498 Ref: Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. PMID: 16192633 Ref: Venous invasion and down-regulation of p21(WAF1/CIP1) are associated with metastasis in colorectal carcinomas. PMID: 16201087 Ref: Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis. PMID: 16211236 Ref: Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells. PMID: 16224795 Ref: Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. PMID: 16226712 Ref: Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells. PMID: 16227409 Ref: Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1. PMID: 16236452 Ref: Dietary components modify gene expression: implications for carcinogenesis. PMID: 16251635 Ref: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. PMID: 16317137 |
Ref: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. PMID: 16170570 Ref: CtIP, a candidate tumor susceptibility gene is a team player with luminaries. PMID: 16249056 Ref: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. PMID: 16280330 Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. PMID: 16407454 Ref: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. PMID: 16407843 Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 Ref: The antitumor effect of a novel differentiation inducer, 2, 2-Bis (4-(4-amino-3-hydroxyphenoxy) phenyl) adamantane (DPA), in combinatory therapy on human colon cancer. PMID: 16525652 Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells. PMID: 16549447 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: Acyclic retinoid, a novel synthetic retinoid, induces growth inhibition, apoptosis, and changes in mRNA expression of cell cycle- and differentiation-related molecules in human colon carcinoma cells. PMID: 16596235 Ref: Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis. PMID: 16619040 Ref: Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence. PMID: 16648559 Ref: Genetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy. PMID: 16686938 Ref: Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. PMID: 16697099 Ref: Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. PMID: 16697692 Ref: Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. PMID: 16709241 Ref: Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate. PMID: 16733561 Ref: Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells. PMID: 16783403 Ref: Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells. PMID: 16818504 Ref: Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells. PMID: 16819292 Ref: Apoptotic effects of over-expressed estrogen receptor-beta on LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. PMID: 16830793 Ref: Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. PMID: 16835297 Ref: Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 16850502 Ref: Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21. PMID: 16858664 Ref: p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). PMID: 16863993 Ref: In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography. PMID: 16885362 Ref: Requirement for pre-existing of p21 to prevent doxorubicin-induced apoptosis through inhibition of caspase-3 activation. PMID: 16909308 Ref: Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. PMID: 16952553 Ref: Diallyl disulfide increases CDKN1A promoter-associated histone acetylation in human colon tumor cell lines. PMID: 17002414 Ref: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. PMID: 17007015 Ref: Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. PMID: 17062697 Ref: Effect of ligand troglitazone on peroxisome proliferator-activated receptor gamma expression and cellular growth in human colon cancer cells. PMID: 17143939 Ref: p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. PMID: 17145870 Ref: Modulation of the cell cycle and induction of apoptosis in human cancer cells by synthetic bile acids. PMID: 17168673 Ref: Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. PMID: 17172426 Ref: [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. 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Ref: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. PMID: 16901994 Ref: Kruppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. PMID: 17016435 Ref: Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. PMID: 17086168 Ref: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. PMID: 17218778 Ref: Berry phenolic extracts modulate the expression of p21(WAF1) and Bax but not Bcl-2 in HT-29 colon cancer cells. PMID: 17243699 Ref: Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. PMID: 17292358 Ref: JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. PMID: 17292881 Ref: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. PMID: 17307743 Ref: Genetic markers predictive of response to induction chemoradiotherapy for locally advanced rectal cancers. PMID: 17310874 Ref: BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. PMID: 17317101 Ref: Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines. PMID: 17343830 Ref: TSC-box is essential for the nuclear localization and antiproliferative effect of XTSC-22. PMID: 17394598 Ref: Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. PMID: 17418982 Ref: Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. PMID: 17455259 Ref: Expression of p21(WAF1) is related to acetylation of histone H3 in total chromatin in human colorectal cancer. PMID: 17465503 Ref: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. PMID: 17486059 Ref: Novel small molecule induces p53-dependent apoptosis in human colon cancer cells. PMID: 17509529 Ref: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. PMID: 17510082 Ref: Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells. PMID: 17559805 Ref: LKB1 catalytically deficient mutants enhance cyclin D1 expression. PMID: 17575127 Ref: p21 (CDKN1A) is a negative regulator of p53 stability. PMID: 17585201 Ref: c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. PMID: 17591974 Ref: Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels. PMID: 17638911 Ref: Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. PMID: 17641414 Ref: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. PMID: 17650425 Ref: Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. PMID: 17671689 Ref: Involvement of RNA helicases p68 and p72 in colon cancer. PMID: 17699760 Ref: The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. PMID: 17786325 Ref: P21WAF1/CIP1 expression in colorectal carcinomas is related to Kras mutations and prognosis. PMID: 17873613 Ref: Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. PMID: 17942926 Ref: Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. PMID: 17950073 Ref: Stimulus-specific transcriptional regulation within the p53 network. PMID: 17957141 Ref: Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. PMID: 17974990 Ref: Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo. PMID: 17982666 Ref: Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. PMID: 17982676 Ref: R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. PMID: 18000499 |
Ref: Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53. PMID: 17942461 Ref: Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells. PMID: 18024214 Ref: Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. PMID: 18172863 Ref: Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin. PMID: 18189140 Ref: Medroxyprogesterone acetate inhibits proliferation of colon cancer cell lines by modulating cell cycle-related protein expression. PMID: 18202593 Ref: Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer. PMID: 18205772 Ref: PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. PMID: 18215742 Ref: p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. PMID: 18223691 Ref: Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. PMID: 18272544 Ref: Sulindac suppresses beta-catenin expression in human cancer cells. PMID: 18291362 Ref: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. PMID: 18320073 Ref: A chemotherapy-associated senescence bystander effect in breast cancer cells. PMID: 18340112 Ref: Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. PMID: 18347191 Ref: Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. PMID: 18348516 Ref: Src kinase induces tumor formation in the c-SRC C57BL/6 mouse. PMID: 18351644 Ref: The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. PMID: 18357397 Ref: Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells. PMID: 18377871 Ref: Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells. PMID: 18414391 Ref: Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis. PMID: 18419600 Ref: CDK inhibitor enhances the sensitivity to 5-fluorouracil in colorectal cancer cells. PMID: 18425338 Ref: Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer. 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Ref: Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer. PMID: 26293890 Ref: LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. PMID: 26400164 Ref: Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. PMID: 26596838 Ref: Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved. PMID: 26634414 Ref: Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53. PMID: 26636733 Ref: Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis. PMID: 26637668 Ref: Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21Cip1/Waf1. PMID: 26821069 Ref: Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. PMID: 26835537 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. PMID: 26895377 Ref: Growth inhibition effects of ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid on colorectal carcinoma cells and colon carcinoma-bearing mice. PMID: 26935771 Ref: Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition. PMID: 26936485 Ref: The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARgamma ligands. PMID: 26995279 Ref: Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4beta-hydroxywithanolide E isolated from Physalis peruviana. PMID: 27006100 Ref: Effect of Recepteur d'Origine Nantais expression on chemosensitivity and tumor cell behavior in colorectal cancer. PMID: 27035413 Ref: Ultraconserved region-containing Transformer 2beta4 controls senescence of colon cancer cells. PMID: 27043659 Ref: An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells. PMID: 27163855 Ref: EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/beta-catenin signaling. PMID: 27172794 Ref: Boletus edulis ribonucleic acid - a potent apoptosis inducer in human colon adenocarcinoma cells. PMID: 27302173 Ref: Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC). PMID: 27302926 Ref: Berry anthocyanins reduce proliferation of human colorectal carcinoma cells by inducing caspase-3 activation and p21 upregulation. PMID: 27314273 Ref: Inactivation of the FoxO3a transcription factor is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated senescence in human colon cancer and breast cancer cells. PMID: 27470586 Ref: miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. PMID: 27509128 Ref: Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells. PMID: 27644562 Ref: TLE3 represses colorectal cancer proliferation by inhibiting MAPK and AKT signaling pathways. PMID: 27669982 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 Ref: Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis. PMID: 27726394 Ref: Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells. PMID: 27748801 Ref: ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer. PMID: 27806345 Ref: Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation. PMID: 27832471 Ref: Bamboo Salt Suppresses Colon Carcinogenesis in C57BL/6 Mice with Chemically Induced Colitis. PMID: 27845862 Ref: Sorbus rufopilosa Extract Exhibits Antioxidant and Anticancer Activities by Inducing Cell Cycle Arrest and Apoptosis in Human Colon Adenocarcinoma HT29 Cells. PMID: 28053959 |
Ref: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. PMID: 26824338 Ref: BTG1 might be employed as a biomarker for carcinogenesis and a target for gene therapy in colorectal cancers. PMID: 27447746 Ref: Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. PMID: 27861153 Ref: Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells. PMID: 27862857 Ref: Ketogenesis contributes to intestinal cell differentiation. PMID: 27935584 Ref: Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. PMID: 28096658 Ref: Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer. PMID: 28112720 Ref: The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression. PMID: 28147305 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. PMID: 28183047 Ref: Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells. PMID: 28266352 Ref: p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. PMID: 28339031 Ref: The DEAD-box RNA helicase DDX41 is a novel repressor of p21(WAF1/CIP1) mRNA translation. PMID: 28348086 Ref: MicroRNA-93-5p increases multidrug resistance in human colorectal carcinoma cells by downregulating cyclin dependent kinase inhibitor 1A gene expression. PMID: 28356951 Ref: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. PMID: 28368414 Ref: Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. PMID: 28386336 Ref: Specific up-regulation of p21 by a small active RNA sequence suppresses human colorectal cancer growth. PMID: 28445988 Ref: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells. PMID: 28555064 Ref: Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A. PMID: 28603560 Ref: KLF4 inhibits colorectal cancer cell proliferation dependent on NDRG2 signaling. PMID: 28656310 Ref: Tumor-selective lipopolyplex encapsulated small active RNA hampers colorectal cancer growth in vitro and in orthotopic murine. PMID: 28666099 Ref: YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. PMID: 28740556 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: p53 performs an essential role in mediating the oncogenic stimulus triggered by loss of expression of neurofibromatosis type 2 during in vitro tumor progression. PMID: 28789444 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. PMID: 28796262 Ref: Anticancer Activity of Ramalin, a Secondary Metabolite from the Antarctic Lichen Ramalina terebrata, against Colorectal Cancer Cells. PMID: 28817102 Ref: In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells. PMID: 28880032 Ref: Jagged-2 (JAG2) enhances tumorigenicity and chemoresistance of colorectal cancer cells. PMID: 28881809 Ref: TRAIL enhances quinacrine-mediated apoptosis in breast cancer cells through induction of autophagy via modulation of p21 and DR5 interactions. PMID: 28936683 Ref: PANDAR: a pivotal cancer-related long non-coding RNA in human cancers. PMID: 28976505 Ref: Melanoma antigen A12 regulates cell cycle via tumor suppressor p21 expression. PMID: 28978129 Ref: Downregulation of ZNF278 arrests the cell cycle and decreases the proliferation of colorectal cancer cells via inhibition of the ERK/MAPK pathway. PMID: 29039562 Ref: Regiospecific Synthesis of Ring A Fused Withaferin A Isoxazoline Analogues: Induction of Premature Senescence by W-2b in Proliferating Cancer Cells. PMID: 29062040 Ref: RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis. PMID: 29137316 Ref: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells. PMID: 29137335 Ref: Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways. PMID: 29237430 Ref: Hyperthermia exposure induces apoptosis and inhibits proliferation in HCT116 cells by upregulating miR-34a and causing transcriptional activation of p53. PMID: 29285066 |
Ref: UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer. PMID: 29196913 Ref: Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer. PMID: 29342159 Ref: Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone mediated autophagy degradation of p21(Cip1/WAF1). PMID: 29355659 Ref: ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner. PMID: 29426877 Ref: Riluzole Inhibits Proliferation, Migration and Cell Cycle Progression and Induces Apoptosis in Tumor Cells of Various Origins. PMID: 29493465 Ref: The prognostic significance of protein arginine methyltransferase 6 expression in colon cancer. PMID: 29507670 Ref: Delineating the underlying molecular mechanisms and key genes involved in metastasis of colorectal cancer via bioinformatics analysis. PMID: 29517105 Ref: Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21(Wif1/Cip1) in Colorectal Cancer Cells. PMID: 29527286 Ref: Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. PMID: 29668110 Ref: Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53-p21(CIP1/WAF1) in human colorectal HCT116 cells. PMID: 29754265 Ref: NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. PMID: 29857489 Ref: HNRNPLL stabilizes mRNA for DNA replication proteins and promotes cell cycle progression in colorectal cancer cells. PMID: 29869816 Ref: LOH12CR1 is a Novel Tumor Suppressor Inhibiting Tumor Growth Through Deregulation of G1/S Checkpoint in Human Colorectal Carcinoma. PMID: 29879888 Ref: [Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells]. PMID: 29891445 Ref: Nucleolin facilitates nuclear retention of an ultraconserved region containing TRA2beta4 and accelerates colon cancer cell growth. PMID: 29928487 Ref: BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells. PMID: 29932276 Ref: Liver kinase B1/adenosine monophosphate-activated protein kinase signaling axis induces p21/WAF1 expression in a p53-dependent manner. PMID: 29963200 Ref: Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp. PMID: 30008606 Ref: Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC. PMID: 30144184 Ref: Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis. PMID: 30147339 Ref: Novel isothiacalothrixin B analogues exhibit cytotoxic activity on human colon cancer cells in vitro by inducing irreversible DNA damage. PMID: 30188913 Ref: The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer. PMID: 30191971 Ref: Increased EZH2 expression during the adenoma-carcinoma sequence in colorectal cancer. PMID: 30214616 Ref: Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells. PMID: 30214687 Ref: RASSF1A suppresses colorectal tumor cell growth through p53-dependent p21(WAF1) activation. PMID: 30226276 Ref: Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma. PMID: 30272263 Ref: A new chalcone derivative, 3-phenyl-1-(2,4,6-tris(methoxymethoxy)phenyl)prop-2-yn-1-one), inhibits phorbol ester-induced metastatic activity of colorectal cancer cells through upregulation of heme oxygenase-1. PMID: 30321531 |